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The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure
M. Caprnda, A. Zulli, HA. Shiwani, P. Kubatka, S. Filipova, V. Valentova, K. Gazdikova, I. Mozos, A. Berukstis, A. Laucevicius, I. Rihacek, J. Dragasek, R. Prosecky, EE. Egom, R. Staffa, P. Kruzliak, V. Krasnik
Jazyk angličtina Země Austrálie
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
32083749
DOI
10.1111/1440-1681.13290
Knihovny.cz E-zdroje
- MeSH
- akutní nemoc MeSH
- lidé MeSH
- natriuretický peptid typu B farmakologie terapeutické užití MeSH
- srdeční selhání farmakoterapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
B-type natriuretic peptide (BNP) exhibits roles in natriuresis and diuresis, making it an ideal drug that may aid in diuresing a fluid-overloaded patient with poor or worsening renal function. Several randomized clinical trials have tested the hypothesis that infusions of pharmacological doses of BNP to acute heart failure (HF) patients may enhance decongestion and preserve renal function in this clinical setting. Unfortunately, none of these have demonstrated beneficial outcomes. The current challenge for BNP research in acute HF lies in addressing a failure of concept and a reluctance to abandon an ineffective research model. Future success will necessitate a detailed understanding of the mechanism of action of BNP, as well as better integration of basic and clinical science.
Clinic of Heart and Vessel Diseases Faculty of Medicine Vilnius University Vilnius Lithuania
Department of Functional Sciences Victor Babes University of Medicine and Pharmacy Timisoara Romania
Department of General Medicine Faculty of Medicine Slovak Medical University Bratislava Slovakia
Department of Internal Medicine Brothers of Mercy Hospital Brno Czech Republic
Egom Clinical and Translational Research Services Ltd Dartmouth NS Canada
Independent Researcher Mosjøen Norway
Institute for Health and Sport Victoria University Melbourne VIC Australia
Jewish General Hospital and Lady Davis Research Institute Montreal QC Canada
Royal Lancaster Infirmary University Hospitals of Morecambe Bay NHS Trust Lancaster UK
Citace poskytuje Crossref.org
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