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Allergen immunotherapy in MASK-air users in real-life: Results of a Bayesian mixed-effects model
B. Sousa-Pinto, LF. Azevedo, A. Sá-Sousa, RJ. Vieira, R. Amaral, L. Klimek, W. Czarlewski, JM. Anto, A. Bedbrook, V. Kvedariene, MT. Ventura, IJ. Ansotegui, KC. Bergmann, L. Brussino, GW. Canonica, V. Cardona, P. Carreiro-Martins, T. Casale, L....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
EIT Health Twinning
Mylan-Viatris
GSK
ALK
Uriach
Novartis
Charité Universitätsmedizin Berlin
EIT Health POLLAR
NLK
BioMedCentral Open Access
od 2011
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
PubMed Central
od 2011
Europe PubMed Central
od 2011
ProQuest Central
od 2015-01-01
Open Access Digital Library
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2015-01-01
Wiley-Blackwell Open Access Titles
od 2011
PubMed
35344295
DOI
10.1002/clt2.12128
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real-life studies. OBJECTIVE: To compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK-air® app: those receiving sublingual AIT (SLIT), those receiving subcutaneous AIT (SCIT), and those receiving no AIT. METHODS: We assessed the MASK-air® data of European users with self-reported grass pollen allergy, comparing the data reported by patients receiving SLIT, SCIT and no AIT. Outcome variables included the daily impact of allergy symptoms globally and on work (measured by visual analogue scales-VASs), and a combined symptom-medication score (CSMS). We applied Bayesian mixed-effects models, with clustering by patient, country and pollen season. RESULTS: We analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT-tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = -12.1;-2.8), lower VAS Work (average difference = 5.0; 95%CrI = -8.5;-1.5), and a lower CSMS (average difference = 3.7; 95%CrI = -9.3;2.2). When compared to SCIT, SLIT-tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = -17.2;-2.8), lower VAS Work (average difference = 7.8; 95%CrI = -15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = -18.5;0.2). CONCLUSION: In patients with grass pollen allergy, SLIT-tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally-harmonised standards for performing and reporting real-world data in AIT are needed to better understand its 'real-world' effectiveness.
ALL MED Medical Research Institute Wroclaw Poland
Allergy Center CUF Descobertas Hospital Lisbon Portugal
Allergy Department 2nd Pediatric Clinic University of Athens Athens Greece
Center for Rhinology and Allergology Wiesbaden Germany
CIBER Epidemiología y Salud Pública Barcelona Spain
CINTESIS Center for Health Technology and Services Research University of Porto Porto Portugal
ClinCompetence Cologne GmbH Cologne Germany
Corporate Member of Freie Universität Berlin Berlin Germany
Department of Allergy and Immunology Hospital Quirónsalud Bizkaia Bilbao Spain
Department of Biomedical Sciences Humanitas University Pieve Emanuele Italy
Department of Clinical Immunology Wrocław Medical University Wroclaw Poland
Department of Immunoallergology Cova da Beira University Hospital Centre Covilhã Portugal
Department of Medicine Clinical Immunology and Allergy McMaster University Hamilton Ontario Canada
Department of Otolaryngology Head and Neck Surgery Eye and Ear University Hospital Beirut Lebanon
Department of Otolaryngology Head and Neck Surgery Universitätsmedizin Mainz Mainz Germany
Department of Otorhinolaryngology Chiba University Hospital Chiba Japan
Department of Otorhinolaryngology Head and Neck Surgery Semmelweis University Budapest Hungary
Department of Pulmonary Medicine and Tuberculosis University Hospital Brno Liskovec Czech Republic
Department of Pulmonary Medicine CHU Sart Tilman Liege Belgium
Department of Pulmonology Celal Bayar University Manisa Turkey
Division of Allergy immunology University of South Florida Tampa Florida USA
Ecole Polytechnique Palaiseau IRBA Bretigny France
EFA European Federation of Allergy and Airways Diseases Patients' Associations Brussels Belgium
ENT Department Dar Al Shifa Hospital Salmiya Kuwait
Eskisehir Osmangazi University Medical Faculty ENT Department Eskisehir Turkey
Faculty of Health Sciences University of Beira Interior Covilhã Portugal
Fundaçao ProAR Federal University of Bahia Salvador Bahia Brazil
Fundacion Jimenez Diaz CIBERES Faculty of Medicine Autonoma University of Madrid Madrid Spain
GARD WHO Planning Group Salvador Bahia Brazil
GIGA I3 Research Group Liege Belgium
Humboldt Universität zu Berlin Berlin Germany
IMSB Medical Faculty University of Cologne Cologne Germany
Institute of Allergology Charité Universitätsmedizin Berlin Berlin Germany
International Primary Care Respiratory Group IPCRG Aberdeen Scotland
ISGlobal Barcelona Institute for Global Health Barcelona Spain
KYomed INNOV Montpellier France
Medical Consulting Czarlewski Levallois France
Medicina EDucação 1 and D e Avaliação Lda Porto Portugal
NOVA Medical School Comprehensive Health Research Centre Lisbon Portugal
Nova Southeastern University Fort Lauderdale Florida USA
Personalized Medicine Asthma and Allergy Humanitas Clinical and Research Center IRCCS Rozzano Italy
Poltava State Medical University Poltava Ukraine
Rhinology Unit and Smell Clinic ENT Department Hospital Clínic Barcelona Spain
School of Medicine University CEU San Pablo Madrid Spain
Servicio de Alergia e Immunologia Clinica Santa Isabel Buenos Aires Argentina
Skin and Allergy Hospital Helsinki University Hospital University of Helsinki Helsinki Finland
SOS Allergology and Clinical Immunology USL Toscana Centro Prato Italy
UBIAir Clinical and Experimental Lung Centre University of Beira Interior Covilhã Portugal
Universitat Pompeu Fabra Barcelona Spain
University Clinic of Respiratory and Allergic Diseases Golnik Slovenia
University Hospital Montpellier Montpellier France
University of Bari Medical School Unit of Geriatric Immunoallergology Bari Italy
University of Ljubljana Faculty of Medicine Ljubljana Slovenia
Citace poskytuje Crossref.org
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