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Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study
P. Mlčák, R. Chlup, P. Kudlová, O. Krystyník, M. Král, V. Kučerová, J. Spurná, S. Titzová, P. Hübnerová, O. Vláčil, I. Šínová, M. Karhanová, J. Zapletalová, M. Šín
Language English Country Great Britain
Document type Journal Article, Randomized Controlled Trial
NLK
Free Medical Journals
from 2008 to 1 year ago
Medline Complete (EBSCOhost)
from 2008-02-01 to 1 year ago
Wiley Free Content
from 2008 to 1 year ago
PubMed
33742561
DOI
10.1111/aos.14853
Knihovny.cz E-resources
- MeSH
- Time Factors MeSH
- Diabetes Mellitus, Type 2 blood complications MeSH
- Glycated Hemoglobin metabolism MeSH
- Cross-Over Studies MeSH
- Smoking adverse effects blood MeSH
- Blood Glucose MeSH
- Oxygen blood MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Retinal Diseases blood etiology MeSH
- Infant, Newborn MeSH
- Oximetry MeSH
- Pilot Projects MeSH
- Prospective Studies MeSH
- Retinal Vessels metabolism physiopathology MeSH
- Oxygen Saturation physiology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Randomized Controlled Trial MeSH
PURPOSE: Purpose of this prospective uncontrolled single-centre pilot study was to find an association of retinal oxygen saturation (SatO2 ) with acid-base balance (ABB), carboxyhaemoglobin concentration, current plasma glucose concentration (PG), mean PG and PG variability over the last 72 hr, haemoglobin A1c (HbA1c), and other conditions. METHODS: Forty-one adults (17 men) with type 1 (N = 14) or type 2 (N = 27) diabetes mellitus, age 48.6 ± 13.5 years, diabetes duration 9 (0.1-36) years, BMI 29.4 ± 6.3 kg/m2 , and HbA1c 52 ± 12.7 mmol/mol completed the study. The 4-day study comprised two visits (Day l, Day 4) including 72 hr of continuous glucose monitoring (CGM) by iPro® 2 Professional CGM (Medtronic, MiniMed, Inc., Northridge, CA, USA). Retinal oximeter Oxymap T1 (Oxymap ehf., Reykjavik, Iceland) was used to assess SatO2 . RESULTS: Wilcoxon signed-rank test showed no SatO2 difference between eyes and visits. Spearman's correlation analysis revealed a significant correlation between arterial SatO2 and PG variability in type 2 diabetes mellitus, a positive correlation of venous SatO2 with HbA1c and with finger pulse oximetry. However, no correlation of SatO2 with ABB, carboxyhaemoglobin, current PG, mean PG over the 72 hr, age, diabetes duration, BMI, lipoproteinaemia, body temperature, systolic and diastolic blood pressure, heart rate, central retinal thickness and retinal nerve fibre layer thickness was found. CONCLUSION: This study confirmed the association of venous SatO2 with long-term but not with short-term diabetes control, ABB and other conditions. The increased SatO2 and questionable impact of PG variability on retinal SatO2 is a research challenge.
Department of Clinical Biochemistry University Hospital Olomouc Olomouc Czech Republic
Department of Health Sciences Faculty of Humanities Tomáš Baťa University Zlín Zlín Czech Republic
References provided by Crossref.org
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- $a Mlčák, Petr $u Department of Ophthalmology, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic $u Department of Physiology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic
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