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Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study
P. Mlčák, R. Chlup, P. Kudlová, O. Krystyník, M. Král, V. Kučerová, J. Spurná, S. Titzová, P. Hübnerová, O. Vláčil, I. Šínová, M. Karhanová, J. Zapletalová, M. Šín
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, randomizované kontrolované studie
NLK
Free Medical Journals
od 2008 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2008-02-01 do Před 1 rokem
Wiley Free Content
od 2008 do Před 1 rokem
PubMed
33742561
DOI
10.1111/aos.14853
Knihovny.cz E-zdroje
- MeSH
- časové faktory MeSH
- diabetes mellitus 2. typu krev komplikace MeSH
- glykovaný hemoglobin metabolismus MeSH
- klinické křížové studie MeSH
- kouření škodlivé účinky krev MeSH
- krevní glukóza MeSH
- kyslík krev MeSH
- lidé MeSH
- následné studie MeSH
- nemoci retiny krev etiologie MeSH
- novorozenec MeSH
- oxymetrie MeSH
- pilotní projekty MeSH
- prospektivní studie MeSH
- retinální cévy metabolismus patofyziologie MeSH
- saturace kyslíkem fyziologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
PURPOSE: Purpose of this prospective uncontrolled single-centre pilot study was to find an association of retinal oxygen saturation (SatO2 ) with acid-base balance (ABB), carboxyhaemoglobin concentration, current plasma glucose concentration (PG), mean PG and PG variability over the last 72 hr, haemoglobin A1c (HbA1c), and other conditions. METHODS: Forty-one adults (17 men) with type 1 (N = 14) or type 2 (N = 27) diabetes mellitus, age 48.6 ± 13.5 years, diabetes duration 9 (0.1-36) years, BMI 29.4 ± 6.3 kg/m2 , and HbA1c 52 ± 12.7 mmol/mol completed the study. The 4-day study comprised two visits (Day l, Day 4) including 72 hr of continuous glucose monitoring (CGM) by iPro® 2 Professional CGM (Medtronic, MiniMed, Inc., Northridge, CA, USA). Retinal oximeter Oxymap T1 (Oxymap ehf., Reykjavik, Iceland) was used to assess SatO2 . RESULTS: Wilcoxon signed-rank test showed no SatO2 difference between eyes and visits. Spearman's correlation analysis revealed a significant correlation between arterial SatO2 and PG variability in type 2 diabetes mellitus, a positive correlation of venous SatO2 with HbA1c and with finger pulse oximetry. However, no correlation of SatO2 with ABB, carboxyhaemoglobin, current PG, mean PG over the 72 hr, age, diabetes duration, BMI, lipoproteinaemia, body temperature, systolic and diastolic blood pressure, heart rate, central retinal thickness and retinal nerve fibre layer thickness was found. CONCLUSION: This study confirmed the association of venous SatO2 with long-term but not with short-term diabetes control, ABB and other conditions. The increased SatO2 and questionable impact of PG variability on retinal SatO2 is a research challenge.
Department of Clinical Biochemistry University Hospital Olomouc Olomouc Czech Republic
Department of Health Sciences Faculty of Humanities Tomáš Baťa University Zlín Zlín Czech Republic
Citace poskytuje Crossref.org
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