-
Je něco špatně v tomto záznamu ?
Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas: An indicator of exposure to vector bites
L. Willen, P. Milton, JID. Hamley, M. Walker, MY. Osei-Atweneboana, P. Volf, MG. Basáñez, O. Courtenay
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
Wellcome Trust - United Kingdom
NLK
Directory of Open Access Journals
od 2007
Free Medical Journals
od 2007
Public Library of Science (PLoS)
od 2007
PubMed Central
od 2007
Europe PubMed Central
od 2007
ProQuest Central
od 2007-10-01
Open Access Digital Library
od 2007-01-01
Open Access Digital Library
od 2007-08-30
Open Access Digital Library
od 2007-01-01
Medline Complete (EBSCOhost)
od 2009-04-01
Health & Medicine (ProQuest)
od 2007-10-01
Public Health Database (ProQuest)
od 2007-10-01
ROAD: Directory of Open Access Scholarly Resources
od 2007
- MeSH
- dítě MeSH
- dospělí MeSH
- hmyz - vektory imunologie parazitologie MeSH
- imunoglobulin G krev MeSH
- imunoglobulin M krev MeSH
- kousnutí a bodnutí hmyzem epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- Onchocerca volvulus růst a vývoj MeSH
- onchocerkóza epidemiologie přenos MeSH
- předškolní dítě MeSH
- protilátky krev MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Simuliidae imunologie parazitologie MeSH
- sliny imunologie MeSH
- zvířata MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: In onchocerciasis endemic areas in Africa, heterogenous biting rates by blackfly vectors on humans are assumed to partially explain age- and sex-dependent infection patterns with Onchocerca volvulus. To underpin these assumptions and further improve predictions made by onchocerciasis transmission models, demographic patterns in antibody responses to salivary antigens of Simulium damnosum s.l. are evaluated as a measure of blackfly exposure. METHODOLOGY/PRINCIPAL FINDINGS: Recently developed IgG and IgM anti-saliva immunoassays for S. damnosum s.l. were applied to blood samples collected from residents in four onchocerciasis endemic villages in Ghana. Demographic patterns in antibody levels according to village, sex and age were explored by fitting generalized linear models. Antibody levels varied between villages but showed consistent patterns with age and sex. Both IgG and IgM responses declined with increasing age. IgG responses were generally lower in males than in females and exhibited a steeper decline in adult males than in adult females. No sex-specific difference was observed in IgM responses. CONCLUSIONS/SIGNIFICANCE: The decline in age-specific antibody patterns suggested development of immunotolerance or desensitization to blackfly saliva antigen in response to persistent exposure. The variation between sexes, and between adults and youngsters may reflect differences in behaviour influencing cumulative exposure. These measures of antibody acquisition and decay could be incorporated into onchocerciasis transmission models towards informing onchocerciasis control, elimination, and surveillance.
Biomedical and Public Health Research Unit CSIR Water Research Institute Accra Ghana
Department of Parasitology Faculty of Science Charles University Prague Czech Republic
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22011343
- 003
- CZ-PrNML
- 005
- 20220506130751.0
- 007
- ta
- 008
- 220425s2022 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1371/journal.pntd.0010108 $2 doi
- 035 __
- $a (PubMed)35020729
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Willen, Laura $u Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic $u Centre for the Evaluation of Vaccinations, Vaccine and Infectious Disease Institute, University of Antwerp, Wilrijk, Belgium $1 https://orcid.org/0000000280278621
- 245 10
- $a Demographic patterns of human antibody levels to Simulium damnosum s.l. saliva in onchocerciasis-endemic areas: An indicator of exposure to vector bites / $c L. Willen, P. Milton, JID. Hamley, M. Walker, MY. Osei-Atweneboana, P. Volf, MG. Basáñez, O. Courtenay
- 520 9_
- $a BACKGROUND: In onchocerciasis endemic areas in Africa, heterogenous biting rates by blackfly vectors on humans are assumed to partially explain age- and sex-dependent infection patterns with Onchocerca volvulus. To underpin these assumptions and further improve predictions made by onchocerciasis transmission models, demographic patterns in antibody responses to salivary antigens of Simulium damnosum s.l. are evaluated as a measure of blackfly exposure. METHODOLOGY/PRINCIPAL FINDINGS: Recently developed IgG and IgM anti-saliva immunoassays for S. damnosum s.l. were applied to blood samples collected from residents in four onchocerciasis endemic villages in Ghana. Demographic patterns in antibody levels according to village, sex and age were explored by fitting generalized linear models. Antibody levels varied between villages but showed consistent patterns with age and sex. Both IgG and IgM responses declined with increasing age. IgG responses were generally lower in males than in females and exhibited a steeper decline in adult males than in adult females. No sex-specific difference was observed in IgM responses. CONCLUSIONS/SIGNIFICANCE: The decline in age-specific antibody patterns suggested development of immunotolerance or desensitization to blackfly saliva antigen in response to persistent exposure. The variation between sexes, and between adults and youngsters may reflect differences in behaviour influencing cumulative exposure. These measures of antibody acquisition and decay could be incorporated into onchocerciasis transmission models towards informing onchocerciasis control, elimination, and surveillance.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a protilátky $x krev $7 D000906
- 650 _2
- $a dítě $7 D002648
- 650 _2
- $a předškolní dítě $7 D002675
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunoglobulin G $x krev $7 D007074
- 650 _2
- $a imunoglobulin M $x krev $7 D007075
- 650 _2
- $a kousnutí a bodnutí hmyzem $x epidemiologie $7 D007299
- 650 _2
- $a hmyz - vektory $x imunologie $x parazitologie $7 D007303
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a Onchocerca volvulus $x růst a vývoj $7 D017181
- 650 _2
- $a onchocerkóza $x epidemiologie $x přenos $7 D009855
- 650 _2
- $a sliny $x imunologie $7 D012463
- 650 _2
- $a Simuliidae $x imunologie $x parazitologie $7 D012843
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Milton, Philip $u MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom $1 https://orcid.org/0000000164658221
- 700 1_
- $a Hamley, Jonathan I D $u MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom $1 https://orcid.org/0000000157552867
- 700 1_
- $a Walker, Martin $u London Centre for Neglected Tropical Disease Research and Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, United Kingdom $1 https://orcid.org/0000000187145365
- 700 1_
- $a Osei-Atweneboana, Mike Y $u Biomedical and Public Health Research Unit, CSIR-Water Research Institute, Accra, Ghana $1 https://orcid.org/0000000285415015
- 700 1_
- $a Volf, Petr $u Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic $1 https://orcid.org/0000000317901123 $7 jo2003163245
- 700 1_
- $a Basáñez, Maria-Gloria $u MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom $1 https://orcid.org/0000000150313361
- 700 1_
- $a Courtenay, Orin $u Zeeman Institute for Systems Biology & Infectious Disease Epidemiology Research and School of Life Sciences, University of Warwick, Coventry, United Kingdom
- 773 0_
- $w MED00165375 $t PLoS neglected tropical diseases $x 1935-2735 $g Roč. 16, č. 1 (2022), s. e0010108
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35020729 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220425 $b ABA008
- 991 __
- $a 20220506130743 $b ABA008
- 999 __
- $a ok $b bmc $g 1789099 $s 1162541
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 16 $c 1 $d e0010108 $e 20220112 $i 1935-2735 $m PLoS neglected tropical diseases $n PLoS negl. trop. dis. $x MED00165375
- GRA __
- $p Wellcome Trust $2 United Kingdom
- LZP __
- $a Pubmed-20220425