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Immunomodulation with β-glucan from Pleurotus ostreatus in patients with endocrine-dependent breast cancer
J. Spacek, M. Vocka, E. Zavadova, B. Konopasek, L. Petruzelka
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
34784798
DOI
10.2217/imt-2021-0069
Knihovny.cz E-resources
- MeSH
- beta-Glucans immunology MeSH
- Immunomodulation immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Breast Neoplasms immunology MeSH
- Pleurotus immunology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Aim: To evaluate the effect of pleuran (β-glucan from Pleurotus ostreatus) administration on the immune profile of patients with endocrine-dependent breast cancer (clinical stages I-II) in clinical and imaging remission. Methodology: Antitumor cellular immunity (CD19+, CD3+, CD4+ and CD8+ T lymphocytes and natural killer cells) of 195 patients (49 in the pleuran group and 146 in the control group) was measured by flow cytometry. Results: We observed a significant increase in the absolute number of CD3+, CD19+, CD4+ and CD8+ T lymphocytes in the pleuran group compared with the control group. Conclusion: Our results suggest potential benefit of continuous pleuran administration on immune rehabilitation of cellular antitumor immunity and better prognosis in breast cancer patients in remission.
References provided by Crossref.org
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