Beta glukany (BG) mají kromě své schopnosti integrovat s imunitním systémem řadu dalších specifických vlastností prospívajících kvalitě pokožky. Potlačují indukci antioxidačních aktivit, redukují rizika environmentálních stresů a tím působí jako přirozený a finančně efektivní přístup k udržení rovnováhy homeostázy pokožky. Rostoucí nabídka preparátů s BG vede k jejich aplikaci jak v kosmetické aplikaci, tak k aplikaci v dermatologii a dalších oborech lékařství. Předkládáme předběžné výsledky úspěšné aplikace krému s BG u seniorů s nálezem plenkové iritační dermatitidy jako proof-of-concept jejich potenciálního využití.
Beta glucans (BG) have not only the ability to cooperate with immune system, but also numerous additional specific properties, which improve quality of the skin. BG suppress induction of antioxidative activities, reduce risk of environmental stress and subsequently act as natural and financially effective method for achieving skin homeostasis. Increasing offer of commercial BG products results in their application in both cosmetics and dermatology and other medical areas. In this study we offer results of our small-scale study using BG-containing cream in senior patients with diaper dermatitis, which might serve as proof-of-concept of BG use.
The aim of this study was to evaluate the effects of pleuran (β-glucan isolated from Pleurotus ostreatus) on asthma control and respiratory morbidity in children on conventional GINA-based asthma treatment who had partially controlled perennial asthma. A double-blind, placebo-controlled multicentre clinical trial with a 2-arm, parallel design was conducted across three countries; 230 children aged 7 to 17 years were randomised (1:1) into an active group (receiving a pleuran/vitamin C combination) or a placebo group (receiving vitamin C only). This study consisted of 24 weeks of treatment (2 capsules a day) and then 24 weeks of follow-up. The primary endpoints included the effects of active treatment versus placebo on asthma control and respiratory tract infections (RTIs). Secondary endpoints included changes in the following measures: number of asthma exacerbations, with or without respiratory infection; quality of life of both asthmatic children and their caregivers; spirometric indices; fractional exhaled nitric oxide (FeNO) levels; safety after 24 weeks of treatment and also after the full 48-week study period. Overall, 206 children completed this study; 113 of these children were in the active group and received a pleuran/vitamin C combination for 24 weeks. After the 24-week treatment period, children below 12 years of age who were in the active group achieved significant improvements in asthma control compared to those in the placebo group (21.8 ± 3.5 vs. 20.3 ± 4.0; P = 0.02); while children at least 12 years old who were in the active group reported lower numbers of RTIs (0.7 ± 1.0 vs. 1.9 ± 1.7; P = 0.002) compared to children of this age in the placebo group. In addition, children below 12 years of age in the active group showed a significant decrease in asthma exacerbations compared to those in the placebo group (2.5 ± 1.6 vs. 3.3 ± 1.9; P = 0.05). At the end of the 48-week trial, a statistically significant improvement in asthma control was observed in 84.7% of children who received pleuran/vitamin C treatment compared to 67.0% of children who received vitamin C only (P = 0.01). The pleuran/vitamin C combined treatment was safe and well-tolerated, and no related serious adverse events were reported. This study highlights the favourable safety profile of pleuran/vitamin C supplementation and demonstrates positive effects of this treatment on asthma control and RTI incidence in children with allergic perennial asthma that was partially controlled by conventional therapy.
- MeSH
- beta-Glucans therapeutic use administration & dosage MeSH
- Asthma * drug therapy MeSH
- Child MeSH
- Double-Blind Method MeSH
- Respiratory Tract Infections * drug therapy MeSH
- Quality of Life MeSH
- Ascorbic Acid therapeutic use administration & dosage MeSH
- Humans MeSH
- Adolescent MeSH
- Pleurotus chemistry MeSH
- Treatment Outcome MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Randomized Controlled Trial MeSH
V současné době zažívají jedlé houby renezanci jako součást zdravé výživy. Jejich význam není pouze využití jako složky potravy, ale jsou zařazeny do skupiny přírodních posilovačů a inhibitorů imunity u řady klinických onemocnění. V tomto přehledu je věnována pozornost jednotlivým složkám hub, které příznivě ovlivňují zdravotní stav populace. Ve vztahu k novým poznatkům jsou sledovány především dvě významné složky hub – vitamin D a polysacharidové formulace, především beta-glukany. Je zdůrazněn význam a přínos zvýšení spotřeby hub pro zlepšení kvality zdravotního stavu populace.
Edible mushrooms are currently considered to be part of healthy diet. Their importance is not only as part of nutrition, but in many clinical diseases they belong to the group of natural stimulators and inhibitors of immune reaction. Our short review is focused on individual parts of mushrooms with positive effects on health status. We present newest findings of two most important parts of mushrooms – vitamin D and polysaccharides, particularly beta glucan. In summary, we discuss the importance and positive effects of an increase of mushroom consumption on improvement of health status of entire population.
- Keywords
- Beta-D-glukany,
- MeSH
- beta-Glucans * pharmacology classification therapeutic use MeSH
- Chemical Engineering methods MeSH
- Immunomodulation immunology drug effects MeSH
- Humans MeSH
- Dietary Fiber pharmacology MeSH
- Prebiotics MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Imunita je důmyslný systém. Imunitní paměť může při správném průběhu trvat desítky let či celý život a významně ovlivňuje naše zdraví a život. Dobře fungující imunitní systém přináší organizmu zdraví a vitalitu ve formě odolnosti i při kontaktu se zákeřným protivníkem jak z řad zevních činitelů, tak vlastních buněk. Betaglukany jsou látky přírodního původu, které umí aktivovat buňky imunitního systému, tedy podpoří tělo v tom, aby si bylo schopno samo pomoci, což je vždy velmi efektivní, a navíc bez vedlejších účinků. Nedoporučují se pouze u pacientů, u kterých není žádoucí zvyšovat a podporovat imunitní procesy. Jsou celosvětově doporučovány jako základní či doplňková léčba zánětů, nádorů, diabetu, hypercholesterolemie a dalších onemocnění.
Immunity is a sophisticated system, including immune memory, which can last for decades or a lifetime if it works correctly and significantly affects our health and therefore life. A well-functioning immune system brings health and vitality to the body in the form of resistance even when in contact with an insidious enemy, both from external agents and from its own cells. Betaglucans are of natural origin and can activate the cells of the immune system, so they support the body in helping itself, which is always very effective; moreover, they are without side effects. They are not recommended only in patients in whom it is not desirable to increase support of the immune processes. They are recommended worldwide as a basic or complementary treatment for inflammation, tumors, diabetes, hypercholesterolemia and other diseases.
Významné účinky β-glukanu vedly v posledních letech k jeho topické aplikaci při hojení ran s jejich následnou reparací, remodelací biosyntézy kolagenu a jeho ukládání, s příznivým účinkem udržování vlhkosti a pružnosti pokožky a tím zlepšením její kvality. Aplikace u pacientů s projevy atopického ekzému prokázala významné zlepšení klinických projevů již po 14 dnech léčby. Příznivý efekt aplikace u dekubitů, především jejich iniciální fáze, byl znatelný již po týdenní léčbě postižené lokality. Tento nález ukazuje i na možnost preventivního podávání β-glukanu u rizikových pacientů.
Significant effects of β-glucan resulted in topical application during wound healing with demonstrated reparation, remodelation of collagen biosynthesis and its deposition, resulting in improvement of skin moisture and elasticity andoverall improvements in skin quality. Application in patients with atopic eczema showed significant improvements afteronly two weeks. Positive effects of betaglucan on decubitus, particularly during initial phases, was found even after one week of treatment. These findings suggest the possibility of preventive use of β-glucan in patients with risk of skin problems.
- MeSH
- beta-Glucans * immunology MeSH
- Immune System MeSH
- Humans MeSH
- Neoplasms therapy MeSH
- Check Tag
- Humans MeSH
Imunita je důmyslný systém. Imunitní paměť může při správném průběhu trvat desítky let či celý život a významně ovlivňuje naše zdraví a život. Dobře fungující imunitní systém přináší organizmu zdraví a vitalitu ve formě odolnosti i při kontaktu se zákeřným protivníkem jak z řad zevních činitelů, tak vlastních buněk. Betaglukany jsou látky přírodního původu, které umí aktivovat buňky imunitního systému, tedy podpoří tělo v tom, aby si bylo schopno samo pomoci, což je vždy velmi efektivní, a navíc bez vedlejších účinků. Nedoporučují se pouze u pacientů, u kterých není žádoucí zvyšovat a podporovat imunitní procesy. Jsou celosvětově doporučovány jako základní či doplňková léčba zánětů, nádorů, diabetu, hypercholesterolemie a dalších onemocnění.
Immunity is a sophisticated system, including immune memory, which can last for decades or a lifetime if it works correctly and significantly affects our health and therefore life. A well-functioning immune system brings health and vitality to the body in the form of resistance even when in contact with an insidious enemy, both from external agents and from its own cells. Betaglucans are of natural origin and can activate the cells of the immune system, so they support the body in helping itself, which is always very effective; moreover, they are without side effects. They are not recommended only in patients in whom it is not desirable to increase support of the immune processes. They are recommended worldwide as a basic or complementary treatment for inflammation, tumors, diabetes, hypercholesterolemia and other diseases.
Aim: To evaluate the effect of pleuran (β-glucan from Pleurotus ostreatus) administration on the immune profile of patients with endocrine-dependent breast cancer (clinical stages I-II) in clinical and imaging remission. Methodology: Antitumor cellular immunity (CD19+, CD3+, CD4+ and CD8+ T lymphocytes and natural killer cells) of 195 patients (49 in the pleuran group and 146 in the control group) was measured by flow cytometry. Results: We observed a significant increase in the absolute number of CD3+, CD19+, CD4+ and CD8+ T lymphocytes in the pleuran group compared with the control group. Conclusion: Our results suggest potential benefit of continuous pleuran administration on immune rehabilitation of cellular antitumor immunity and better prognosis in breast cancer patients in remission.
- MeSH
- beta-Glucans immunology MeSH
- Immunomodulation immunology MeSH
- Middle Aged MeSH
- Humans MeSH
- Breast Neoplasms immunology MeSH
- Pleurotus immunology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Memory-like responses in innate immune cells confer nonspecific protection against secondary exposures. A number of microbial agents have been found to induce enhanced or diminished recall responses in innate cells, however, studies investigating the ability of probiotic bacteria to trigger such effects are lacking. Here, we show that priming of human monocytes with a secretome from the gut probiotic bacterium Limosilactobacillus (L.) reuteri induces a mixed secondary response phenotype in monocyte-derived dendritic cells (mo-DCs), with a strong IL-6 and IL-1β response but low TNFα, IL-23 and IL-27 secretion. Instead, blood DC priming with L. reuteri-secretome resembles a tolerant state upon secondary exposure. A similar pattern was found in conventional and gut-like (retinoic acid exposed) DCs, although retinoic acid hampered TNFα and IL-6 production and enrichment of histone modifications in L. reuteri-secretome primed mo-DC cultures. Further, we show that the memory-like phenotype of mo-DCs, induced by priming stimuli, is important for subsequent T helper (Th) cell differentiation pathways and might determine the inflammatory nature of Th cells. We also show enhanced recall responses characterized by robust inflammatory cytokines and lactate production in the gut-like mo-DCs derived from β-glucan primed monocytes. Such responses were accompanied with enriched histone modifications at the promoter of genes associated with a trained phenotype in myeloid cells. Altogether, we demonstrate that a gut commensal-derived secretome prompts recall responses in human DCs which differ from that induced by classical training agents such as β-glucan. Our results could be beneficial for future therapeutic interventions where T cell responses are needed to be modulated.
- MeSH
- beta-Glucans * MeSH
- Cell Differentiation MeSH
- Cytokines MeSH
- Dendritic Cells MeSH
- Phenotype MeSH
- Interleukin-6 MeSH
- Humans MeSH
- Limosilactobacillus reuteri * MeSH
- Monocytes MeSH
- Gastrointestinal Microbiome * MeSH
- Tumor Necrosis Factor-alpha pharmacology MeSH
- Tretinoin pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
