OBJECTIVES: The aim of the study was to evaluate the immune status of young people from the Vojvodina province, Serbia, through the detection of IgG antibodies specific for the L1 protein of HPV types 6, 11, 16, and 18 contained in quadrivalent vaccine. METHODS: The study enrolled 514 healthy persons of both genders, aged between 18 and 30 years. All potential participants were informed about the project's aims by trained interviewers before venous blood collection. Also, participants completed a specially designed anonymous questionnaire to identify socio-demographic characteristics and individual behaviours associated with HPV seroprevalence. VPL HPV L1-specific IgG antibodies were measured using a semi-quantitative HPV IgG ELISA kit (Dia.Pro, Italy). RESULTS: A total of 472 (91.8%) young subjects had no detectable antibodies against high- and low-risk HPV types covered by the quadrivalent vaccine. A slightly higher number of seropositive individuals were detected in the age group of 26-30 years compared to younger than 25. Multivariate analysis showed that the number of lifetime sexual partners was the most powerful predictor of HPV seropositivity (OR = 3.483, 95% CI: 1.294-9.379). CONCLUSIONS: Obtained data point out low levels of naturally induced HPV-specific serum antibodies among the target population in the Vojvodina province. The present work highlights the significance and potential benefits of HPV vaccination. Routine HPV vaccination should be the public health priority in our country and should be included in the national immunization programme as soon as possible.

• MeSH
• dospělí MeSH
• imunoglobulin G MeSH
• infekce papilomavirem * epidemiologie   prevence a kontrola   MeSH
• kombinované vakcíny MeSH
• lidé MeSH
• lidské papilomaviry MeSH
• mladiství MeSH
• mladý dospělý MeSH
• protilátky virové MeSH
• séroepidemiologické studie MeSH
• vakcíny proti papilomavirům * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Jugoslávie MeSH
• Srbsko MeSH

• MeSH
• epidemie dějiny   MeSH
• karanténa dějiny   organizace a řízení   MeSH
• kontrola infekčních nemocí dějiny   organizace a řízení   MeSH
• lidé MeSH
• pravé neštovice * přenos   prevence a kontrola   terapie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• historické články MeSH
• novinové články MeSH
• Geografické názvy
• Jugoslávie MeSH
• Kosovo MeSH

BACKGROUND: Latitude gradients and secular trends in Europe and North America have been found in the male-female ratio at birth (M/F: male births divided by total births) which approximates 0.515. METHODS: Annual national data for Yugoslavia and the post-Yugoslavia States for male and female live births were obtained from the World Health Organisation and analysed with contingency tables. RESULTS: This study analysed 22,020,729 live births. There was a increasing trend in M/F prior to the breakup of the former Yugoslavia (1950-1990, p = 0.002), followed by a decreasing trend after 1990 (p = 0.02). A latitude gradient was also noted, with more males being born in southern, warmer latitudes (p < 0.0001). There was an overall excess of 42,753 male births based on an anticipated M/F of 0.515. CONCLUSION: M/F is decreasing in this region, similar to the rest of Europe and North America. A latitude gradient is also present with more males being born in warmer (more Southern) latitudes (p < 0.0001), even in this small region and over the short time-frame studied.

• MeSH
• lidé MeSH
• poměr pohlaví * MeSH
• porodnost etnologie   trendy   MeSH
• sekularismus * MeSH
• zeměpis MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Jugoslávie MeSH

The founder of physiology studies in the Balkans and the pioneer of research on hypothermia, Ivan Djaja (Jean Giaja) was born 1884 in L'Havre. Giaja gained his PhD at the Sorbonne in 1909. In 1910 he established the first Chair of Physiology in the Balkans and organized the first Serbian Institute for Physiology at the School of Philosophy of the University of Belgrade. He led this Institute for more than 40 subsequent years. His most notable papers were in the field of thermoregulation and bioenergetics. Djaja became member of the Serbian and Croatian academies of science and doctor honoris causa of Sorbonne. In 1952 for the seminal work on the behavior of deep cooled warm blooded animals he became associate member of the National Medical Academy in Paris. In 1955 the French Academy of Sciences elected him as associate member in place of deceased Sir Alexander Fleming. Djaja died in 1957 during a congress held in his honor. He left more than 200 scientific and other papers and the golden DaVincian credo "Nulla dies sine experimento". His legacy was continued by several generations of researchers, the most prominent among them being Stefan Gelineo, Radoslav Andjus and Vojislav Petrović.

• MeSH
• dějiny lékařství MeSH
• energetický metabolismus fyziologie   MeSH
• fyziologie dějiny   MeSH
• hypotermie MeSH
• lidé MeSH
• neuroendokrinní buňky fyziologie   metabolismus   MeSH
• statistika jako téma MeSH
• termoregulace fyziologie   MeSH
• univerzity MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• biografie MeSH
• historické články MeSH
• Geografické názvy
• Jugoslávie MeSH
• Srbsko MeSH

• O autorovi
• Djaja, Ivan, 1884-1957 Autorita
• Gelineo, Stefan, 1898- Autorita
• Andjus, Radoslav K., 1926- Autorita
• Petrović, Vojislav M., 1925- Autorita

After an 18-hour bus ride, a 29-year-old soldier complained of leg pain. Ten days later, he collapsed. After cardiopulmonary resuscitation (CPR), he revived but complained of chest pain and shortness of breath. Computed tomography revealed massive thrombus in the right pulmonary artery, emboli in the left pulmonary artery, and right ventricle ballooning. Adequate anticoagulation required repeated boluses and continuous infusion (1,600 units/hour) of heparin. Vena caval filter was not available, and possible additional clot in the legs could not be completely assessed. After no improvement in 24 hours, alteplase was given (10 mg IV bolus and 90 mg over 2 hours). At 12 hours, tachycardia, tachypnea, and dyspnea resolved and computed tomography revealed marked resolution. This case illustrates both the value of CPR and aggressive fibrinolytic therapy in patients who suddenly collapse from massive pulmonary embolism. The collapse was likely due to a saddle embolus. Chest compressions probably fractured the large clot. Although not completely reestablished, enough flow occurred for successful resuscitation. Even though delayed, fibrinolytic therapy was effective and should be considered even in patients where vena caval filter placement is not feasible and/or complete evaluation of the extremity deep venous system is not possible.

• MeSH
• časové faktory MeSH
• dospělí MeSH
• fibrinolytika aplikace a dávkování   terapeutické užití   MeSH
• kardiopulmonální resuscitace * MeSH
• lidé MeSH
• ozbrojené síly * MeSH
• plicní embolie diagnóza   etiologie   terapie   MeSH
• počítačová rentgenová tomografie MeSH
• tkáňový aktivátor plazminogenu aplikace a dávkování   terapeutické užití   MeSH
• žilní trombóza komplikace   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Geografické názvy
• Česká republika MeSH
• Jugoslávie MeSH

The aim of this project was to explore the problem of substance misuse among adolescent town dwellers in Kosovo, as a result of lack of a national strategy related to this problem. DESIGN: 261 students from 4 secondary schools took part in cross sectional survey performed in October 2005. The survey was carried out in Gjilan town in south-east of Kosovo. MAIN RESULTS: From all questioned students, 36% smoked cigarettes every day, 12.6% consumed alcohol occasionally and 1.4% consumed all kind of drugs regularly. Girls consumed more cigarettes, whereas boys consumed more alcohol and other drugs. The prevalence of substance misuse was higher among students in their last year of high school attendance. Students in Gjilan continue to smoke, consume alcohol and drugs despite their knowledge about the adverse health consequences of substance misuse, but in the same time, most of them consider information and counselling the best way of substance misuse prevention. CONCLUSIONS: The prevalence and trends of substance misuse among students in our survey indicates that it is time to start acting. It is assumed that results of survey may be a very useful source of information for policy-makers, government and ministry of health in developing and implementing national strategy that would address the most important issues in connection with addiction among adolescents.

• MeSH
• chování mladistvých MeSH
• kouření epidemiologie   MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• pití alkoholu epidemiologie   MeSH
• poruchy spojené s užíváním psychoaktivních látek epidemiologie   MeSH
• prevalence MeSH
• průřezové studie MeSH
• průzkumy a dotazníky MeSH
• rozdělení chí kvadrát MeSH
• zdraví - znalosti, postoje, praxe MeSH
• zdraví ve městech MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Geografické názvy
• Jugoslávie MeSH

A cross-sectional study was carried out in Velika Hoča and Orahovac, two rural communities in Kosovo and Metohia, with the aim of assessing the prevalence of chronic diseases and associated risk factors. Methods: The study involved 423 (180 male) adult inhabitants aged 51±16 years and included an interview, medical documentation, physical, ultrasound, laboratory examinations and ECG. Results: Hyperlipidemia was the most frequent (70%) risk factor followed by alcohol consumption (47%), hypertension (42%), smoking (36%) and obesity (32%). Ischemic heart disease was diagnosed in 25 patients, hypertensive cardiomyopathy in 17, other cardiomyopathies in 5 and arrhythmia in 20 patients. Nine persons had chronic obstructive pulmonary disease. Previously diagnosed liver cirrhosis occurred in 5 and chronic hepatitis in 8 subjects, while liver steatosis with elevated serum transaminases (22 persons), elevated transaminases with normal ultrasound (20 persons), tumor or suspected tumor (7 persons) were detected in the survey. Gastrointestinal symptoms were the most prevalent but peptic ulcer and gastritis had been previously diagnosed in 64 and 47 patients. Kidney and urinary tract diseases were known for 52 patients (12 with chronic renal failure and 4 on hemodialysis) and 46 more were detected in the study. Among them in 22 patients with markers of kidney disease and unclear diagnosis 12 had a positive family history, 8 low-grade proteinuria, 14 tubular dysfunctions and 7 eGFR (estimated glomerular filtration rate) below 60 ml/min/1.73 m2. Conclusion: In the Serbian enclave of Velika Hoča and Orahovac the prevalence of cardiovascular diseases was similar to that of gastrointestinal, liver and kidney diseases. This differs from other parts of Serbia where cardiovascular disorders are the leading cause of disease burden.

• Klíčová slova
• chronic disease prevalence, rural community, Kosovo and Metohia,
• MeSH
• chronická nemoc epidemiologie   MeSH
• dospělí MeSH
• financování organizované MeSH
• gastrointestinální nemoci epidemiologie   MeSH
• kardiovaskulární nemoci epidemiologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• nemoci jater epidemiologie   MeSH
• nemoci ledvin epidemiologie   MeSH
• prevalence MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• venkovské obyvatelstvo statistika a číselné údaje   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Geografické názvy
• Jugoslávie MeSH

• MeSH
• endokrinologie MeSH
• popálení MeSH
• Publikační typ
• biografie MeSH
• Geografické názvy
• Jugoslávie MeSH

• O autorovi
• Doleček, Rajko, 1925-2017 Autorita

• MeSH
• kalibrace MeSH
• lidé MeSH
• operační sály normy   zásobování a distribuce   MeSH
• referenční standardy MeSH
• řízení kvality MeSH
• vládní organizace MeSH
• vojenské lékařství metody   normy   MeSH
• vojenské nemocnice zásobování a distribuce   MeSH
• zákonodárství jako téma MeSH
• zdravotnické prostředky normy   MeSH
• Check Tag
• lidé MeSH
• Geografické názvy
• Afghánistán MeSH
• Jugoslávie MeSH

• Klíčová slova
• legislativa, specifická profylaxe,
• MeSH
• břišní tyfus prevence a kontrola   MeSH
• lidé MeSH
• meningokokové vakcíny aplikace a dávkování   terapeutické užití   MeSH
• poliovirové vakcíny aplikace a dávkování   terapeutické užití   MeSH
• tropické lékařství metody   MeSH
• vakcína proti hepatitidě A aplikace a dávkování   terapeutické užití   MeSH
• vakcína proti hepatitidě B aplikace a dávkování   terapeutické užití   MeSH
• vakcinace metody   využití   MeSH
• vakcíny škodlivé účinky   MeSH
• vládní organizace MeSH
• vojenské lékařství metody   organizace a řízení   MeSH
• zákonodárství jako téma MeSH
• Check Tag
• lidé MeSH
• Geografické názvy
• Afghánistán MeSH
• Česká republika MeSH
• Jugoslávie MeSH