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Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy

NM. Gregg, V. Sladky, P. Nejedly, F. Mivalt, I. Kim, I. Balzekas, BK. Sturges, C. Crowe, EE. Patterson, JJ. Van Gompel, BN. Lundstrom, K. Leyde, TJ. Denison, BH. Brinkmann, V. Kremen, GA. Worrell

. 2021 ; 11 (1) : 24250. [pub] 20211220

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22011676

Grantová podpora
R01 NS092882 NINDS NIH HHS - United States
U01 NS073557 NINDS NIH HHS - United States
UH2 NS095495 NINDS NIH HHS - United States
MC_UU_00003/3 Medical Research Council - United Kingdom
UH3 NS095495 NINDS NIH HHS - United States

Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.

Citace poskytuje Crossref.org

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$a Thalamic deep brain stimulation modulates cycles of seizure risk in epilepsy / $c NM. Gregg, V. Sladky, P. Nejedly, F. Mivalt, I. Kim, I. Balzekas, BK. Sturges, C. Crowe, EE. Patterson, JJ. Van Gompel, BN. Lundstrom, K. Leyde, TJ. Denison, BH. Brinkmann, V. Kremen, GA. Worrell
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$a Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.
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