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Autor
Balzekas, Irena 1 Brinkmann, Benjamin H 1 Crowe, Chelsea 1 Denison, Timothy J 1 Gregg, Nicholas M 1 Kim, Inyong 1 Kremen, Vaclav 1 Leyde, Kent 1 Lundstrom, Brian N 1 Mivalt, Filip 1 Nejedly, Petr 1 Patterson, Edward E 1 Sladky, Vladimir 1 Sturges, Beverly K 1 Van Gompel, Jamie J 1 Worrell, Gregory A 1
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Pracoviště
Cadence Neuroscience Seattle WA 98052... 1 Czech Institute of Informatics Roboti... 1 Department of Biomedical Engineering ... 1 Department of Neurology Bioelectronic... 1 Department of Neurosurgery Mayo Clini... 1 Department of Veterinary Clinical Sci... 1 Department of Veterinary Clinical Sci... 1 Faculty of Biomedical Engineering Cze... 1 Institute for Biomedical Engineering ... 1 International Clinical Research Cente... 1 Mayo Clinic School of Medicine and th... 1
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Autor
Balzekas, Irena 1 Brinkmann, Benjamin H 1 Crowe, Chelsea 1 Denison, Timothy J 1 Gregg, Nicholas M 1 Kim, Inyong 1 Kremen, Vaclav 1 Leyde, Kent 1 Lundstrom, Brian N 1 Mivalt, Filip 1 Nejedly, Petr 1 Patterson, Edward E 1 Sladky, Vladimir 1 Sturges, Beverly K 1 Van Gompel, Jamie J 1 Worrell, Gregory A 1
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Pracoviště
Cadence Neuroscience Seattle WA 98052... 1 Czech Institute of Informatics Roboti... 1 Department of Biomedical Engineering ... 1 Department of Neurology Bioelectronic... 1 Department of Neurosurgery Mayo Clini... 1 Department of Veterinary Clinical Sci... 1 Department of Veterinary Clinical Sci... 1 Faculty of Biomedical Engineering Cze... 1 Institute for Biomedical Engineering ... 1 International Clinical Research Cente... 1 Mayo Clinic School of Medicine and th... 1
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- Gregg, Nicholas M
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Sladky, Vladimir
Autor Sladky, Vladimir Department of Neurology, Bioelectronics Neurophysiology and Engineering Laboratory, Mayo Clinic, Rochester, MN, 55905, USA International Clinical Research Center, St. Anne's University Hospital, 656 91, Brno, Czech Republic Faculty of Biomedical Engineering, Czech Technical University in Prague, 272 01, Kladno, Czech Republic
- Nejedly, Petr
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Mivalt, Filip
Autor Mivalt, Filip ORCID Department of Neurology, Bioelectronics Neurophysiology and Engineering Laboratory, Mayo Clinic, Rochester, MN, 55905, USA International Clinical Research Center, St. Anne's University Hospital, 656 91, Brno, Czech Republic Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication, Brno University of Technology, 616 00, Brno, Czech Republic
- Kim, Inyong
- Balzekas, Irena
- Sturges, Beverly K
- Crowe, Chelsea
- Patterson, Edward E
- Van Gompel, Jamie J
Free Medical Journals od 2011
Nature Open Access od 2011-12-01
PubMed Central od 2011
Europe PubMed Central od 2011
ProQuest Central od 2011-01-01
Open Access Digital Library od 2011-01-01
Open Access Digital Library od 2011-01-01
Health & Medicine (ProQuest) od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources od 2011
PubMed
34930926
DOI
10.1038/s41598-021-03555-7
Knihovny.cz E-zdroje
Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and multiday cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and multiday IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and multiday (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.
- MeSH
- cirkadiánní rytmus MeSH
- elektroencefalografie MeSH
- epilepsie prevence a kontrola MeSH
- hluboká mozková stimulace metody MeSH
- lidé MeSH
- psi MeSH
- riziko MeSH
- thalamus fyziologie MeSH
- záchvaty prevence a kontrola MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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