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Retinal oximetry does not predict 12-month visual outcome after anti-VEGF treatment for central retinal vein occlusion: A multicentre study
S. Krejberg Jeppesen, M. Sín, S. Hakon Hardarson, T. Bek
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
Grantová podpora
TheToyotaFoundation
FightforSightDenmark
Synoptik-
Fonden
(
CopenhagenDenmark
)
IcelandicResearchCouncil
UniversityofIcelandResearchFund
HelgaJónsdóttirandSigurliðiKristjánssonMemorialFund
NLK
Free Medical Journals
od 2008 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2008-02-01 do Před 1 rokem
Wiley Free Content
od 2008 do Před 1 rokem
PubMed
33421320
DOI
10.1111/aos.14744
Knihovny.cz E-zdroje
- MeSH
- časové faktory MeSH
- fluoresceinová angiografie metody MeSH
- inhibitory angiogeneze aplikace a dávkování MeSH
- injekce intravitreální MeSH
- kyslík analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- následné studie MeSH
- okluze retinální žíly metabolismus patofyziologie MeSH
- optická koherentní tomografie metody MeSH
- oxymetrie metody MeSH
- prediktivní hodnota testů MeSH
- ranibizumab aplikace a dávkování MeSH
- retina diagnostické zobrazování metabolismus patofyziologie MeSH
- retinální cévy patofyziologie MeSH
- retrospektivní studie MeSH
- saturace kyslíkem fyziologie MeSH
- senioři MeSH
- vaskulární endoteliální růstový faktor A antagonisté a inhibitory MeSH
- výsledek terapie MeSH
- zraková ostrost * MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
PURPOSE: Central retinal vein occlusion (CRVO) entails retinal hypoxia that often causes visual impairment. It has been shown that oxygen saturation in larger retinal vessels correlates with the visual acuity at the time of diagnosis of CRVO but has no predictive value for the visual outcome in patients treated with anti-VEGF medication after 3 months. However, assessing the predictive value of retinal oxygen saturation after 12 months is essential because this is when the main restitution after CRVO occurs. METHODS: Retinal oximetry was performed in 117 patients referred with CRVO to three European centres. The correlation between oxygen saturation and visual acuity at baseline and the predictive value of oxygen saturation in larger retinal vessels for the 12-month visual outcome after treatment with anti-VEGF medication were studied. RESULTS: In the affected eye, the oxygen saturation was significantly higher in the arterioles, significantly lower in the venules, and the arterio-venous (A-V) significantly higher than in the unaffected eye (p < 0.001 for all comparisons). Correlations between best-corrected visual acuity (BCVA) and oxygen saturations were moderate and negative for arterioles (p < 0.001), positive for venules (p = 0.03) and negative for the A-V difference (p = 0.001). Best-corrected visual acuity (BCVA), but not oxygen saturation or the other explanatory variables at baseline, contributed significantly to predicting BCVA after 12 months. CONCLUSION: Retinal vessel oxygen saturation is affected in CRVO, and saturation correlates with BCVA. However, retinal oximetry cannot replace measures of visual function as a predictor of visual outcome after 12 months of anti-VEGF treatment for CRVO.
Department of Ophthalmology Aarhus University Hospital Aarhus N Denmark
Department of Ophthalmology and Physiology University of Iceland Reykjavik Iceland
Citace poskytuje Crossref.org
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