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Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery
M. Ashrafizadeh, A. Zarrabi, S. Mirzaei, F. Hashemi, S. Samarghandian, A. Zabolian, K. Hushmandi, HL. Ang, G. Sethi, AP. Kumar, KS. Ahn, N. Nabavi, H. Khan, P. Makvandi, RS. Varma
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, přehledy
- MeSH
- antitumorózní látky fytogenní aplikace a dávkování terapeutické užití MeSH
- apoptóza účinky léků MeSH
- kyselina gallová aplikace a dávkování terapeutické užití MeSH
- lidé MeSH
- nádory farmakoterapie MeSH
- nanočásticový lékový transportní systém * aplikace a dávkování terapeutické užití MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Cancer is the second leading cause of death worldwide. Majority of recent research efforts in the field aim to address why cancer resistance to therapy develops and how to overcome or prevent it. In line with this, novel anti-cancer compounds are desperately needed for chemoresistant cancer cells. Phytochemicals, in view of their pharmacological activities and capacity to target various molecular pathways, are of great interest in the development of therapeutics against cancer. Plant-derived-natural products have poor bioavailability which restricts their anti-tumor activity. Gallic acid (GA) is a phenolic acid exclusively found in natural sources such as gallnut, sumac, tea leaves, and oak bark. In this review, we report on the most recent research related to anti-tumor activities of GA in various cancers with a focus on its underlying molecular mechanisms and cellular pathwaysthat that lead to apoptosis and migration of cancer cells. GA down-regulates the expression of molecular pathways involved in cancer progression such as PI3K/Akt. The co-administration of GA with chemotherapeutic agents shows improvements in suppressing cancer malignancy. Various nano-vehicles such as organic- and inorganic nano-materials have been developed for targeted delivery of GA at the tumor site. Here, we suggest that nano-vehicles improve GA bioavailability and its ability for tumor suppression.
Department of Basic Medical Sciences Neyshabur University of Medical Sciences Neyshabur Iran
Department of Pharmacy Abdul Wali Khan University Mardan 23200 Pakistan
Sabanci University Nanotechnology Research and Application Center Tuzla 34956 Istanbul Turkey
Young Researchers and Elite Club Tehran Medical Sciences Islamic Azad University Tehran Iran
Citace poskytuje Crossref.org
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- $a Ashrafizadeh, Milad $u Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956, Istanbul, Turkey; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul, Turkey
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- $a Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery / $c M. Ashrafizadeh, A. Zarrabi, S. Mirzaei, F. Hashemi, S. Samarghandian, A. Zabolian, K. Hushmandi, HL. Ang, G. Sethi, AP. Kumar, KS. Ahn, N. Nabavi, H. Khan, P. Makvandi, RS. Varma
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- $a Cancer is the second leading cause of death worldwide. Majority of recent research efforts in the field aim to address why cancer resistance to therapy develops and how to overcome or prevent it. In line with this, novel anti-cancer compounds are desperately needed for chemoresistant cancer cells. Phytochemicals, in view of their pharmacological activities and capacity to target various molecular pathways, are of great interest in the development of therapeutics against cancer. Plant-derived-natural products have poor bioavailability which restricts their anti-tumor activity. Gallic acid (GA) is a phenolic acid exclusively found in natural sources such as gallnut, sumac, tea leaves, and oak bark. In this review, we report on the most recent research related to anti-tumor activities of GA in various cancers with a focus on its underlying molecular mechanisms and cellular pathwaysthat that lead to apoptosis and migration of cancer cells. GA down-regulates the expression of molecular pathways involved in cancer progression such as PI3K/Akt. The co-administration of GA with chemotherapeutic agents shows improvements in suppressing cancer malignancy. Various nano-vehicles such as organic- and inorganic nano-materials have been developed for targeted delivery of GA at the tumor site. Here, we suggest that nano-vehicles improve GA bioavailability and its ability for tumor suppression.
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- $a Zarrabi, Ali $u Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul, Turkey; Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Sariyer, Istanbul 34396, Turkey
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- $a Mirzaei, Sepideh $u Department of Biology, Faculty of Science, Islamic Azad University, Science and Research Branch, Tehran, Iran
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- $a Ang, Hui Li $u Cancer Science Institute of Singapore and Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore
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- $a Kumar, Alan Prem $u Cancer Science Institute of Singapore and Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore; NUS Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore
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- $a Ahn, Kwang Seok $u Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea
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- $a Nabavi, Noushin $u Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, V6H3Z6, Canada
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- $a Khan, Haroon $u Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan. Electronic address: hkdr2006@gmail.com
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- $a Makvandi, Pooyan $u Centre for Materials Interfaces, Istituto Italiano di Tecnologia, viale Rinaldo Piaggio 34, 56025, Pontedera, Pisa, Italy. Electronic address: pooyanmakvandi@gmail.com
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- $a Varma, Rajender S $u Regional Center of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University, Šlechtitelů 27, 783 71, Olomouc, Czech Republic. Electronic address: Varma.Rajender@epa.gov
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