-
Je něco špatně v tomto záznamu ?
Eosinophils are dispensable for development of MOG35-55-induced experimental autoimmune encephalomyelitis in mice
K. Ruppova, JH. Lim, G. Fodelianaki, A. August, A. Neuwirth
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
- MeSH
- chemokin CCL11 metabolismus MeSH
- encefalomyelitida autoimunitní experimentální krev diagnóza imunologie patologie MeSH
- eozinofily imunologie metabolismus MeSH
- glykoprotein v myelinu oligodendrocytů aplikace a dávkování imunologie MeSH
- lidé MeSH
- mícha imunologie patologie MeSH
- myši transgenní MeSH
- myši MeSH
- peptidové fragmenty aplikace a dávkování imunologie MeSH
- roztroušená skleróza krev diagnóza imunologie patologie MeSH
- stupeň závažnosti nemoci MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Experimental autoimmune encephalomyelitis (EAE) represents the mouse model of multiple sclerosis, a devastating neurological disorder. EAE development and progression involves the infiltration of different immune cells into the brain and spinal cord. However, less is known about a potential role of eosinophil granulocytes for EAE disease pathogenesis. In the present study, we found enhanced eosinophil abundance accompanied by increased concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice by immunization with MOG35-55 peptide. However, the absence of eosinophils did not affect neuroinflammation, demyelination and clinical development or severity of EAE, as assessed in ∆dblGATA1 eosinophil-deficient mice. Taken together, despite their enhanced abundance in the inflamed spinal cord during disease progression, eosinophils were dispensable for EAE development.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22011991
- 003
- CZ-PrNML
- 005
- 20220506125948.0
- 007
- ta
- 008
- 220425s2021 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.imlet.2021.09.001 $2 doi
- 035 __
- $a (PubMed)34499922
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Ruppova, Klara $u Institute for Clinical Chemistry and Laboratory Medicine, University Clinic, Technische Universität Dresden, Dresden, Germany
- 245 10
- $a Eosinophils are dispensable for development of MOG35-55-induced experimental autoimmune encephalomyelitis in mice / $c K. Ruppova, JH. Lim, G. Fodelianaki, A. August, A. Neuwirth
- 520 9_
- $a Experimental autoimmune encephalomyelitis (EAE) represents the mouse model of multiple sclerosis, a devastating neurological disorder. EAE development and progression involves the infiltration of different immune cells into the brain and spinal cord. However, less is known about a potential role of eosinophil granulocytes for EAE disease pathogenesis. In the present study, we found enhanced eosinophil abundance accompanied by increased concentration of the eosinophil chemoattractant eotaxin-1 in the spinal cord in the course of EAE induced in C57BL/6 mice by immunization with MOG35-55 peptide. However, the absence of eosinophils did not affect neuroinflammation, demyelination and clinical development or severity of EAE, as assessed in ∆dblGATA1 eosinophil-deficient mice. Taken together, despite their enhanced abundance in the inflamed spinal cord during disease progression, eosinophils were dispensable for EAE development.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a chemokin CCL11 $x metabolismus $7 D054413
- 650 _2
- $a encefalomyelitida autoimunitní experimentální $x krev $x diagnóza $x imunologie $x patologie $7 D004681
- 650 _2
- $a eozinofily $x imunologie $x metabolismus $7 D004804
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a myši transgenní $7 D008822
- 650 _2
- $a roztroušená skleróza $x krev $x diagnóza $x imunologie $x patologie $7 D009103
- 650 _2
- $a glykoprotein v myelinu oligodendrocytů $x aplikace a dávkování $x imunologie $7 D063308
- 650 _2
- $a peptidové fragmenty $x aplikace a dávkování $x imunologie $7 D010446
- 650 _2
- $a stupeň závažnosti nemoci $7 D012720
- 650 _2
- $a mícha $x imunologie $x patologie $7 D013116
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Lim, Jong-Hyung $u Institute for Clinical Chemistry and Laboratory Medicine, University Clinic, Technische Universität Dresden, Dresden, Germany
- 700 1_
- $a Fodelianaki, Georgia $u Institute for Clinical Chemistry and Laboratory Medicine, University Clinic, Technische Universität Dresden, Dresden, Germany
- 700 1_
- $a August, Avery $u Department of Microbiology & Immunology, Cornell Center for Immunology, Cornell Institute for Host-Microbe Interactions & Disease, Cornell Center for Health Equity, Cornell University, Ithaca, NY, USA
- 700 1_
- $a Neuwirth, Ales $u Institute for Clinical Chemistry and Laboratory Medicine, University Clinic, Technische Universität Dresden, Dresden, Germany; Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: ales.neuwirth@img.cas.cz
- 773 0_
- $w MED00002200 $t Immunology letters $x 1879-0542 $g Roč. 239, č. - (2021), s. 72-76
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/34499922 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220425 $b ABA008
- 991 __
- $a 20220506125940 $b ABA008
- 999 __
- $a ok $b bmc $g 1789538 $s 1163192
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 239 $c - $d 72-76 $e 20210906 $i 1879-0542 $m Immunology letters $n Immunol Lett $x MED00002200
- LZP __
- $a Pubmed-20220425
