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CNS Involvement in Chronic Inflammatory Demyelinating Polyneuropathy: Subtle Retinal Changes in Optical Coherence Tomography
J. Ingwersen, J. Graf, J. Kluge, M. Weise, M. Dietrich, JI. Lee, J. Harmel, HP. Hartung, T. Ruck, SG. Meuth, P. Albrecht, O. Aktas, M. Ringelstein
Neurology® neuroimmunology & neuroinflammation.
2022 ;
9 (1) :
.
[pub] 20211019
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc22012082
Online
Plný text
NLK
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- MeSH
- chronická zánětlivá demyelinizační polyneuropatie diagnostické zobrazování patologie patofyziologie MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- nervové vedení fyziologie MeSH
- optická koherentní tomografie MeSH
- prospektivní studie MeSH
- průřezové studie MeSH
- retina diagnostické zobrazování patologie MeSH
- senioři MeSH
- zrakové dráhy diagnostické zobrazování patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND AND OBJECTIVES: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease primarily affecting the peripheral nervous system. However, several noncontrolled studies have suggested concomitant inflammatory CNS demyelination similar to multiple sclerosis. The aim of this study was to investigate an involvement of the visual pathway in patients with CIDP. METHODS: In this prospective cross-sectional study, we used high-resolution spectral-domain optical coherence tomography to compare the thickness of the peripapillary retinal nerve fiber layer and the deeper macular retinal layers as well as the total macular volume (TMV) in 22 patients with CIDP and 22 age-matched and sex-matched healthy control (HC) individuals. Retinal layers were semiautomatically segmented by the provided software and were correlated with clinical measures and nerve conduction studies. RESULTS: In patients with CIDP compared with healthy age-matched and sex-matched controls, we found slight but significant volume reductions of the ganglion cell/inner plexiform layer complex (CIDP 1.86 vs HC 1.95 mm3, p = 0.015), the retinal pigment epithelium (CIDP 0.38 vs HC 0.40 mm3, p = 0.02), and the TMV (CIDP 8.48 vs HC 8.75 mm3, p = 0.018). The ganglion cell layer volume and motor nerve conduction velocity were positively associated (B = 0.002, p = 0.02). DISCUSSION: Our data reveal subtle retinal neurodegeneration in patients with CIDP, providing evidence for visual pathway involvement, detectable by OCT. The results need corroboration in independent, larger cohorts.
Brain and Mind Centre University of Sydney
Department of Neurology Center for Neurology and Neuropsychiatry LVR Klinikum Düsseldorf Germany
Department of Neurology Medical University of Vienna Austria
Department of Neurology Palacky University in Olomouc Olomouc Czech Republic
From the Department of Neurology Medical Faculty Heinrich Heine University Düsseldorf Germany
Citace poskytuje Crossref.org
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