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Impact of human papillomavirus infection on semen parameters and reproductive outcomes
H. Jaworek, V. Koudelakova, I. Oborna, B. Zborilova, J. Brezinova, D. Ruzickova, J. Vrbkova, P. Kourilova, M. Hajduch
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
LM2018133
Ministerstvo Školství, Mládeže a Tělovýchovy
CZ.02.1.01/0.0/0.0/16_019/0000868
European Regional Development Fund
IGA_LF_2021_019
Univerzita Palackého v Olomouci
TN01000013
Technology Agency of the Czech Republic
NLK
BioMedCentral
od 2003-12-01
BioMedCentral Open Access
od 2003
Directory of Open Access Journals
od 2003
Free Medical Journals
od 2003
PubMed Central
od 2003
Europe PubMed Central
od 2003
ProQuest Central
od 2009-01-01
Open Access Digital Library
od 2003-01-01
Open Access Digital Library
od 2003-01-01
Open Access Digital Library
od 2003-01-01
Medline Complete (EBSCOhost)
od 2003-01-01
Health & Medicine (ProQuest)
od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2003
Springer Nature OA/Free Journals
od 2003-12-01
- MeSH
- analýza spermatu MeSH
- charakteristiky rodiny MeSH
- dárci tkání statistika a číselné údaje MeSH
- dospělí MeSH
- fertilizace in vitro statistika a číselné údaje MeSH
- infekce papilomavirem komplikace diagnóza epidemiologie MeSH
- infertilita komplikace diagnóza epidemiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- Papillomaviridae fyziologie MeSH
- prognóza MeSH
- sperma fyziologie virologie MeSH
- těhotenství MeSH
- výsledek těhotenství epidemiologie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
BACKGROUND: Human papillomavirus (HPV) has been shown to adversely affect human reproduction. We aimed to evaluate the prevalence of human papillomavirus (HPV) infection in men and its correlation with semen parameters and reproductive outcomes. METHODS: Semen samples and penile swabs were collected from potential sperm donors (SD, n = 97) and male partners of infertile couples (IM, n = 328). The presence of HPV DNA in semen samples and penile swabs was analyzed. Associations between hrHPV positive status and fertility outcomes as well as socio-behavioral and health characteristics were evaluated using the R software package. RESULTS: High-risk HPV (hrHPV) genotypes were detected in 28.9% of SD and 35.1% of IM (P = 0.312). Penile swabs were more frequently positive for hrHPV genotypes than semen samples in both IM (32.3% vs. 11.9%, P < 0.001) and SD (26.8% vs. 6.2%, P = 0.006). Men with hrHPV positive semen samples had lower semen volume (median volume 2.5 ml vs. 3 ml, P = 0.009), sperm concentration (median concentration 16 × 106/ml vs. 31 × 106/ml, P = 0.009) and total sperm count (median count 46 × 106 vs. 82 × 106, P = 0.009) than men with hrHPV negative samples. No association was identified between penile hrHPV status and semen parameters. CONCLUSIONS: Our findings indicate that penile HPV infection is common in both potential sperm donors and men from infertile couples. Although HPV positivity is higher in penile swabs, only HPV infection in semen samples affects sperm parameters. However, there was no association between hrHPV positivity in semen and fertility outcomes including abortion rate.
Arleta IVF Ltd Komenskeho 702 517 41 Kostelec nad Orlici Czech Republic
Fertimed Ltd Boleslavova 2 776 00 Olomouc Czech Republic
SpermBank International Katerinska 13 779 00 Olomouc Czech Republic
Citace poskytuje Crossref.org
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- $a BACKGROUND: Human papillomavirus (HPV) has been shown to adversely affect human reproduction. We aimed to evaluate the prevalence of human papillomavirus (HPV) infection in men and its correlation with semen parameters and reproductive outcomes. METHODS: Semen samples and penile swabs were collected from potential sperm donors (SD, n = 97) and male partners of infertile couples (IM, n = 328). The presence of HPV DNA in semen samples and penile swabs was analyzed. Associations between hrHPV positive status and fertility outcomes as well as socio-behavioral and health characteristics were evaluated using the R software package. RESULTS: High-risk HPV (hrHPV) genotypes were detected in 28.9% of SD and 35.1% of IM (P = 0.312). Penile swabs were more frequently positive for hrHPV genotypes than semen samples in both IM (32.3% vs. 11.9%, P < 0.001) and SD (26.8% vs. 6.2%, P = 0.006). Men with hrHPV positive semen samples had lower semen volume (median volume 2.5 ml vs. 3 ml, P = 0.009), sperm concentration (median concentration 16 × 106/ml vs. 31 × 106/ml, P = 0.009) and total sperm count (median count 46 × 106 vs. 82 × 106, P = 0.009) than men with hrHPV negative samples. No association was identified between penile hrHPV status and semen parameters. CONCLUSIONS: Our findings indicate that penile HPV infection is common in both potential sperm donors and men from infertile couples. Although HPV positivity is higher in penile swabs, only HPV infection in semen samples affects sperm parameters. However, there was no association between hrHPV positivity in semen and fertility outcomes including abortion rate.
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