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Immunological configuration of ovarian carcinoma: features and impact on disease outcome
J. Fucikova, A. Coosemans, S. Orsulic, D. Cibula, I. Vergote, L. Galluzzi, R. Spisek
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, přehledy
Grantová podpora
I01 BX004974
BLRD VA - United States
R01 CA208753
NCI NIH HHS - United States
Directory of Open Access Journals od 2013
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PubMed Central od 2013
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ROAD: Directory of Open Access Scholarly Resources od 2013
Odkazy
PubMed
34645669
DOI
10.1136/jitc-2021-002873
Knihovny.cz E-zdroje
- MeSH
- epiteliální ovariální karcinom imunologie MeSH
- imunosupresivní léčba metody MeSH
- imunoterapie metody MeSH
- lidé MeSH
- nádorové mikroprostředí MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. At odds with other neoplasms, EOC is virtually insensitive to immune checkpoint inhibitors, correlating with a tumor microenvironment that exhibits poor infiltration by immune cells and active immunosuppression. Here, we comparatively summarize the humoral and cellular features of primary and metastatic EOC, comparatively analyze their impact on disease outcome, and propose measures to alter them in support of treatment sensitivity and superior patient survival.
Caryl and Israel Englander Institute for Precision Medicine New York NY USA
Department of Radiation Oncology Weill Cornell Medical College New York NY USA
Sandra and Edward Meyer Cancer Center New York NY USA
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- $a Fucikova, Jitka $u Sotio Biotech, Prague, Czech Republic fucikova@sotio.com $u Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic $1 https://orcid.org/000000028423479X $7 xx0116819
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- $a Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. At odds with other neoplasms, EOC is virtually insensitive to immune checkpoint inhibitors, correlating with a tumor microenvironment that exhibits poor infiltration by immune cells and active immunosuppression. Here, we comparatively summarize the humoral and cellular features of primary and metastatic EOC, comparatively analyze their impact on disease outcome, and propose measures to alter them in support of treatment sensitivity and superior patient survival.
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