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Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing

S. Yang, S. Gigout, A. Molinaro, Y. Naito-Matsui, S. Hilton, S. Foscarin, B. Nieuwenhuis, CL. Tan, J. Verhaagen, T. Pizzorusso, LM. Saksida, TM. Bussey, H. Kitagawa, JCF. Kwok, JW. Fawcett

. 2021 ; 26 (10) : 5658-5668. [pub] 20210716

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22012163

Grantová podpora
G1000864 Medical Research Council - United Kingdom
294502 European Research Council - International
MR/R004463 Medical Research Council - United Kingdom
MR/V002694/1 Medical Research Council - United Kingdom
MC_PC_16050 Medical Research Council - United Kingdom
MRC-CIC MC-PC-16050 Medical Research Council - United Kingdom
MR/S011110/1 Medical Research Council - United Kingdom
MR/R004463/1 Medical Research Council - United Kingdom

E-zdroje Online Plný text

NLK ProQuest Central od 2000-01-01 do Před 1 rokem
Open Access Digital Library od 1997-01-01
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
Psychology Database (ProQuest) od 2000-01-01 do Před 1 rokem

Odkazy

PubMed 34272488
DOI 10.1038/s41380-021-01208-9
Knihovny.cz E-zdroje

Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of neuroplasticity and memory. Age-related reduction of chondroitin 6-sulphates (C6S) leads to PNNs becoming more inhibitory. Here, we investigated whether manipulation of the chondroitin sulphate (CS) composition of the PNNs could restore neuroplasticity and alleviate memory deficits in aged mice. We first confirmed that aged mice (20-months) showed memory and plasticity deficits. They were able to retain or regain their cognitive ability when CSs were digested or PNNs were attenuated. We then explored the role of C6S in memory and neuroplasticity. Transgenic deletion of chondroitin 6-sulfotransferase (chst3) led to a reduction of permissive C6S, simulating aged brains. These animals showed very early memory loss at 11 weeks old. Importantly, restoring C6S levels in aged animals rescued the memory deficits and restored cortical long-term potentiation, suggesting a strategy to improve age-related memory impairment.

Citace poskytuje Crossref.org

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