AIM: To evaluate serum levels of selected cytokine receptors in B-cell precursor acute lymphoblastic leukemia (B-ALL) and their association with acknowledged prognostic factors, relapse-free survival (RFS) and overall survival (OS). MATERIALS AND METHODS: A total of 42 de novo adult B-ALL patients, 19 BCR/ABL positive, were included in this study. Soluble receptor α for IL-2 (sIL-2Rα), soluble receptor for IL-6 (sIL-6R), soluble receptor for TNF-α type I and II (sTNFR-1, sTNFR-2) and matrix metalloproteinase-9 (MMP-9) were measured by biochip array technology at diagnosis and in complete remission (CR). RESULTS: At diagnosis of B-ALL, we found significantly higher levels of sIL-2Rα, sIL-6R, sTNFR-1, sTNFR-2 and significantly lower levels MMP-9 in comparison with CR (p < 0.001 in all cases). BCR/ABL positive patients had higher levels of sIL-2Rα at diagnosis (r = 0.484; p = 0.014). Serum levels of evaluated cytokines were not associated with achievement of CR after one cycle of induction therapy, RFS or OS. CONCLUSION: Serum levels of all evaluated cytokines are significantly altered in newly diagnosed B-ALL reflecting activity of the disease. No significant correlations with response to first induction therapy, RFS or OS were found. Further studies with a longer follow-up will be needed.

Department of Internal Medicine 4 Hematology University Hospital and Charles University Faculty of Medicine 500 05 Hradec Kralove Czech Republic

Department of Military Internal Medicine and Military Hygiene University of Defence Faculty of Military Health Sciences 500 01 Hradec Kralove Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc22012240

003      

CZ-PrNML

005      

20240206151827.0

007      

ta

008      

220425s2021 un f 000 0|eng||

009      

AR

024    7_

$a 10.32471/exp-oncology.2312-8852.vol-43-no-3.16548 $2 doi

035    __

$a (PubMed)34591424

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a un

100    1_

$a Horacek, J M $u Department of Military Internal Medicine and Military Hygiene, University of Defence, Faculty of Military Health Sciences, 500 01 Hradec Kralove, Czech Republic

245    10

$a Evaluation of serum levels of selected cytokine receptors in adult B-cell precursor acute lymphoblastic leukemia and their association with prognostic factors and survival / $c JM. Horacek, T. Kupsa, J. Vanek, M. Jakl, M. Stajer, L. Jebavy, P. Zak

520    9_

$a AIM: To evaluate serum levels of selected cytokine receptors in B-cell precursor acute lymphoblastic leukemia (B-ALL) and their association with acknowledged prognostic factors, relapse-free survival (RFS) and overall survival (OS). MATERIALS AND METHODS: A total of 42 de novo adult B-ALL patients, 19 BCR/ABL positive, were included in this study. Soluble receptor α for IL-2 (sIL-2Rα), soluble receptor for IL-6 (sIL-6R), soluble receptor for TNF-α type I and II (sTNFR-1, sTNFR-2) and matrix metalloproteinase-9 (MMP-9) were measured by biochip array technology at diagnosis and in complete remission (CR). RESULTS: At diagnosis of B-ALL, we found significantly higher levels of sIL-2Rα, sIL-6R, sTNFR-1, sTNFR-2 and significantly lower levels MMP-9 in comparison with CR (p < 0.001 in all cases). BCR/ABL positive patients had higher levels of sIL-2Rα at diagnosis (r = 0.484; p = 0.014). Serum levels of evaluated cytokines were not associated with achievement of CR after one cycle of induction therapy, RFS or OS. CONCLUSION: Serum levels of all evaluated cytokines are significantly altered in newly diagnosed B-ALL reflecting activity of the disease. No significant correlations with response to first induction therapy, RFS or OS were found. Further studies with a longer follow-up will be needed.

650    _2

$a dospělí $7 D000328

650    _2

$a senioři $7 D000368

650    _2

$a protokoly antitumorózní kombinované chemoterapie $x terapeutické užití $7 D000971

650    _2

$a nádorové biomarkery $x krev $7 D014408

650    _2

$a ženské pohlaví $7 D005260

650    _2

$a následné studie $7 D005500

650    _2

$a lidé $7 D006801

650    _2

$a indukční chemoterapie $x mortalita $7 D060828

650    _2

$a mužské pohlaví $7 D008297

650    _2

$a lidé středního věku $7 D008875

650    _2

$a pre-B-buněčná leukemie $x krev $x farmakoterapie $x mortalita $x patologie $7 D015452

650    _2

$a prognóza $7 D011379

650    _2

$a receptory cytokinové $x krev $7 D018121

650    _2

$a míra přežití $7 D015996

650    _2

$a mladý dospělý $7 D055815

655    _2

$a časopisecké články $7 D016428

700    1_

$a Kupsa, T $u Department of Military Internal Medicine and Military Hygiene, University of Defence, Faculty of Military Health Sciences, 500 01 Hradec Kralove, Czech Republic

700    1_

$a Vanek, J $u Department of Military Internal Medicine and Military Hygiene, University of Defence, Faculty of Military Health Sciences, 500 01 Hradec Kralove, Czech Republic

700    1_

$a Jakl, Martin $7 xx0135493

700    1_

$a Stajer, M $u Department of Military Internal Medicine and Military Hygiene, University of Defence, Faculty of Military Health Sciences, 500 01 Hradec Kralove, Czech Republic

700    1_

$a Jebavy, L $u Department of Military Internal Medicine and Military Hygiene, University of Defence, Faculty of Military Health Sciences, 500 01 Hradec Kralove, Czech Republic

700    1_

$a Zak, P $u Department of Internal Medicine IV - Hematology, University Hospital and Charles University, Faculty of Medicine, 500 05 Hradec Kralove, Czech Republic

773    0_

$w MED00174402 $t Experimental oncology $x 1812-9269 $g Roč. 43, č. 3 (2021), s. 234-236

856    41

$u https://pubmed.ncbi.nlm.nih.gov/34591424 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y p $z 0

990    __

$a 20220425 $b ABA008

991    __

$a 20240206151824 $b ABA008

999    __

$a ok $b bmc $g 1789710 $s 1163441

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2021 $b 43 $c 3 $d 234-236 $e - $i 1812-9269 $m Experimental oncology $n Exp Oncol $x MED00174402

LZP    __

$a Pubmed-20220425