-
Je něco špatně v tomto záznamu ?
Genetic architectures of proximal and distal colorectal cancer are partly distinct
JR. Huyghe, TA. Harrison, SA. Bien, H. Hampel, JC. Figueiredo, SL. Schmit, DV. Conti, S. Chen, C. Qu, Y. Lin, R. Barfield, JA. Baron, AJ. Cross, B. Diergaarde, D. Duggan, S. Harlid, L. Imaz, HM. Kang, DM. Levine, V. Perduca, A. Perez-Cornago, LC....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, metaanalýza, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
P01 CA087969
NCI NIH HHS - United States
P30 CA015704
NCI NIH HHS - United States
U01 CA137088
NCI NIH HHS - United States
U01 CA164930
NCI NIH HHS - United States
HHSN268201200008C
NHLBI NIH HHS - United States
R01 CA201407
NCI NIH HHS - United States
UM1 CA186107
NCI NIH HHS - United States
R01 CA207371
NCI NIH HHS - United States
R01 CA042182
NCI NIH HHS - United States
R01 CA059045
NCI NIH HHS - United States
R35 CA197735
NCI NIH HHS - United States
U10 CA037429
NCI NIH HHS - United States
U01 CA182883
NCI NIH HHS - United States
UG1 CA189974
NCI NIH HHS - United States
R01 CA151993
NCI NIH HHS - United States
R21 CA191312
NCI NIH HHS - United States
U01 CA206110
NCI NIH HHS - United States
P30 CA008748
NCI NIH HHS - United States
U01 CA167551
NCI NIH HHS - United States
UM1 CA182883
NCI NIH HHS - United States
K07 CA190673
NCI NIH HHS - United States
HHSN268201200008I
NHLBI NIH HHS - United States
P30 CA071789
NCI NIH HHS - United States
NLK
ProQuest Central
od 1960-03-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 1960-03-01 do Před 6 měsíci
- MeSH
- alely MeSH
- běloši genetika MeSH
- cékum MeSH
- celogenomová asociační studie MeSH
- colon ascendens MeSH
- colon descendens MeSH
- colon sigmoideum MeSH
- colon transversum MeSH
- dospělí MeSH
- genetická heterogenita * MeSH
- genotyp MeSH
- jednonukleotidový polymorfismus MeSH
- kolon * MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nádory rekta diagnóza genetika MeSH
- nádory tračníku diagnóza genetika MeSH
- rizikové faktory MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- věk při počátku nemoci MeSH
- věkové rozložení MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
OBJECTIVE: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined. DESIGN: To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling. RESULTS: We identified 13 loci that reached genome-wide significance (p<5×10-8) and that were not reported by previous GWASs for overall CRC risk. Multiple lines of evidence support candidate genes at several of these loci. We detected substantial heterogeneity between anatomical subsites. Just over half (61) of 109 known and new risk variants showed no evidence for heterogeneity. In contrast, 22 variants showed association with distal CRC (including rectal cancer), but no evidence for association or an attenuated association with proximal CRC. For two loci, there was strong evidence for effects confined to proximal colon cancer. CONCLUSION: Genetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumour.
Behavioral and Epidemiology Research Group American Cancer Society Atlanta Georgia USA
Broad Institute of Harvard and MIT Cambridge Massachusetts USA
Cancer Epidemiology Division Cancer Council Victoria Melbourne Victoria Australia
Cancer Epidemiology Unit Nuffield Department of Population Health University of Oxford Oxford UK
Center for Public Health Genomics University of Virginia Charlottesville Virginia USA
CIBER Epidemiología y Salud Pública Madrid Spain
City of Hope National Medical Center Duarte California USA
Clalit National Cancer Control Center Haifa Israel
Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington USA
Department of Biostatistics University of Washington Seattle Washington USA
Department of Clinical Genetics Karolinska University Hospital Stockholm Sweden
Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain
Department of Community Medicine and Epidemiology Lady Davis Carmel Medical Center Haifa Israel
Department of Computer Science Stanford University Stanford California USA
Department of Epidemiology and Biostatistics Imperial College London London UK
Department of Epidemiology German Institute of Human Nutrition Potsdam Rehbrücke Germany
Department of Epidemiology University of Washington Seattle Washington USA
Department of Family Medicine University of Virginia Charlottesville Virginia USA
Department of General Surgery University Hospital Rostock Rostock Germany
Department of Genetics Stanford University Stanford California USA
Department of Genome Sciences University of Washington Seattle Washington USA
Department of Health Science Research Mayo Clinic Scottsdale Arizona USA
Department of Internal Medicine University of Utah Health Salt Lake City Utah USA
Department of Medicine 1 University Hospital Dresden Technische Universität Dresden Dresden Germany
Department of Medicine University of Washington School of Medicine Seattle Washington USA
Department of Medicine Weill Cornell Medical College New York New York USA
Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden
Department of Oncologic Pathology Dana Farber Cancer Institute Boston Massachusetts USA
Department of Pathology School of Medicine Umm Al Qura'a University Mecca Saudi Arabia
Department of Public Health and Primary Care University of Cambridge Cambridge UK
Department of Public Health Solutions National Institute for Health and Welfare Helsinki Finland
Department of Radiation Sciences Oncology Unit Umeå University Umeå Sweden
Dipartimento di Medicina Clinica e Chirurgia University of Naples Federico 2 Naples Italy
Discipline of Genetics Memorial University of Newfoundland St John's Newfoundland Canada
Division of Cancer Control and Population Sciences National Cancer Institute Bethesda Maryland USA
Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland USA
Division of Cancer Epidemiology German Cancer Research Centre Heidelberg Germany
Division of Clinical Epidemiology German Cancer Research Centre Heidelberg Germany
Division of Epidemiology and Community Health University of Minnesota Minneapolis Minnesota USA
Division of Human Nutrition and Health Wageningen University and Research Wageningen The Netherlands
Division of Preventive Oncology German Cancer Research Centre Heidelberg Germany
Division of Research Kaiser Permanente Medical Care Program Oakland California USA
Division of Research Kaiser Permanente Northern California Oakland California USA
Faculty of Medicine and Biomedical Center in Pilsen Charles University Pilsen Czech Republic
Genomic Medicine and Family Cancer Clinic Royal Melbourne Hospital Melbourne Victoria Australia
Genomic Medicine Institute Cleveland Clinic Cleveland Ohio USA
German Cancer Consortium Heidelberg Germany
Hellenic Health Foundation Athens Greece
Institut Gustave Roussy Université Paris Saclay Villejuif France
Institute for Health Research Kaiser Permanente Colorado Denver Colorado USA
Institute of Cancer Research Department of Medicine 1 Medical University of Vienna Vienna Austria
Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
Institute of Epidemiology PopGen Biobank Christian Albrechts University Kiel Kiel Germany
Laboratoire de Mathématiques Appliquées MAP5 Université Paris Descartes Paris France
Leeds Institute of Medical Research at St James's University of Leeds Leeds UK
Medical Faculty University of Heidelberg Heidelberg Germany
Ontario Institute for Cancer Research Toronto Ontario Canada
Public Health Division of Gipuzkoa Health Department of Basque Country San Sebastian Spain
Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle Washington USA
Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel
School of Public Health Imperial College London London UK
Service de Génétique Médicale Centre Hospitalier Universitaire de Nantes Nantes France
SWOG Statistical Center Fred Hutchinson Cancer Research Center Seattle Washington USA
The Clalit Health Services Personalized Genomic Service Carmel Medical Center Haifa Israel
Translational Genomics Research Institute An Affiliate of City of Hope Phoenix Arizona USA
University of Hawai'i Cancer Center Honolulu Hawaii USA
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22012363
- 003
- CZ-PrNML
- 005
- 20220506130519.0
- 007
- ta
- 008
- 220425s2021 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1136/gutjnl-2020-321534 $2 doi
- 035 __
- $a (PubMed)33632709
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Huyghe, Jeroen R $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA $1 https://orcid.org/0000000160279806
- 245 10
- $a Genetic architectures of proximal and distal colorectal cancer are partly distinct / $c JR. Huyghe, TA. Harrison, SA. Bien, H. Hampel, JC. Figueiredo, SL. Schmit, DV. Conti, S. Chen, C. Qu, Y. Lin, R. Barfield, JA. Baron, AJ. Cross, B. Diergaarde, D. Duggan, S. Harlid, L. Imaz, HM. Kang, DM. Levine, V. Perduca, A. Perez-Cornago, LC. Sakoda, FR. Schumacher, ML. Slattery, AE. Toland, FJB. van Duijnhoven, B. Van Guelpen, A. Agudo, D. Albanes, MH. Alonso, K. Anderson, C. Arnau-Collell, V. Arndt, BL. Banbury, MC. Bassik, SI. Berndt, S. Bézieau, DT. Bishop, J. Boehm, H. Boeing, MC. Boutron-Ruault, H. Brenner, S. Brezina, S. Buch, DD. Buchanan, A. Burnett-Hartman, BJ. Caan, PT. Campbell, PR. Carr, A. Castells, S. Castellví-Bel, AT. Chan, J. Chang-Claude, SJ. Chanock, KR. Curtis, A. de la Chapelle, DF. Easton, DR. English, EJM. Feskens, M. Gala, SJ. Gallinger, WJ. Gauderman, GG. Giles, PJ. Goodman, WM. Grady, JS. Grove, A. Gsur, MJ. Gunter, RW. Haile, J. Hampe, M. Hoffmeister, JL. Hopper, WL. Hsu, WY. Huang, TJ. Hudson, M. Jenab, MA. Jenkins, AD. Joshi, TO. Keku, C. Kooperberg, T. Kühn, S. Küry, L. Le Marchand, F. Lejbkowicz, CI. Li, L. Li, W. Lieb, A. Lindblom, NM. Lindor, S. Männistö, SD. Markowitz, RL. Milne, L. Moreno, N. Murphy, R. Nassir, K. Offit, S. Ogino, S. Panico, PS. Parfrey, R. Pearlman, PDP. Pharoah, AI. Phipps, EA. Platz, JD. Potter, RL. Prentice, L. Qi, L. Raskin, G. Rennert, HS. Rennert, E. Riboli, C. Schafmayer, RE. Schoen, D. Seminara, M. Song, YR. Su, CM. Tangen, SN. Thibodeau, DC. Thomas, A. Trichopoulou, CM. Ulrich, K. Visvanathan, P. Vodicka, L. Vodickova, V. Vymetalkova, K. Weigl, SJ. Weinstein, E. White, A. Wolk, MO. Woods, AH. Wu, GR. Abecasis, DA. Nickerson, PC. Scacheri, A. Kundaje, G. Casey, SB. Gruber, L. Hsu, V. Moreno, RB. Hayes, PA. Newcomb, U. Peters
- 520 9_
- $a OBJECTIVE: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined. DESIGN: To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling. RESULTS: We identified 13 loci that reached genome-wide significance (p<5×10-8) and that were not reported by previous GWASs for overall CRC risk. Multiple lines of evidence support candidate genes at several of these loci. We detected substantial heterogeneity between anatomical subsites. Just over half (61) of 109 known and new risk variants showed no evidence for heterogeneity. In contrast, 22 variants showed association with distal CRC (including rectal cancer), but no evidence for association or an attenuated association with proximal CRC. For two loci, there was strong evidence for effects confined to proximal colon cancer. CONCLUSION: Genetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumour.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a věkové rozložení $7 D017677
- 650 _2
- $a věk při počátku nemoci $7 D017668
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a alely $7 D000483
- 650 _2
- $a studie případů a kontrol $7 D016022
- 650 _2
- $a cékum $7 D002432
- 650 12
- $a kolon $7 D003106
- 650 _2
- $a colon ascendens $7 D044682
- 650 _2
- $a colon descendens $7 D044683
- 650 _2
- $a colon sigmoideum $7 D012809
- 650 _2
- $a colon transversum $7 D044684
- 650 _2
- $a nádory tračníku $x diagnóza $x genetika $7 D003110
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 12
- $a genetická heterogenita $7 D018740
- 650 _2
- $a celogenomová asociační studie $7 D055106
- 650 _2
- $a genotyp $7 D005838
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a jednonukleotidový polymorfismus $7 D020641
- 650 _2
- $a nádory rekta $x diagnóza $x genetika $7 D012004
- 650 _2
- $a rizikové faktory $7 D012307
- 650 _2
- $a běloši $x genetika $7 D044465
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a metaanalýza $7 D017418
- 655 _2
- $a Research Support, N.I.H., Extramural $7 D052061
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Harrison, Tabitha A $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Bien, Stephanie A $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Hampel, Heather $u Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
- 700 1_
- $a Figueiredo, Jane C $u Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA $u Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
- 700 1_
- $a Schmit, Stephanie L $u Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA
- 700 1_
- $a Conti, David V $u Department of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
- 700 1_
- $a Chen, Sai $u Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
- 700 1_
- $a Qu, Conghui $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Lin, Yi $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Barfield, Richard $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Baron, John A $u Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
- 700 1_
- $a Cross, Amanda J $u Department of Epidemiology and Biostatistics, Imperial College London, London, UK
- 700 1_
- $a Diergaarde, Brenda $u Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA $u UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA
- 700 1_
- $a Duggan, David $u Translational Genomics Research Institute - An Affiliate of City of Hope, Phoenix, Arizona, USA
- 700 1_
- $a Harlid, Sophia $u Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden
- 700 1_
- $a Imaz, Liher $u Public Health Division of Gipuzkoa, Health Department of Basque Country, San Sebastian, Spain
- 700 1_
- $a Kang, Hyun Min $u Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
- 700 1_
- $a Levine, David M $u Department of Biostatistics, University of Washington, Seattle, Washington, USA
- 700 1_
- $a Perduca, Vittorio $u Laboratoire de Mathématiques Appliquées MAP5 (UMR CNRS 8145), Université Paris Descartes, Paris, France $u Centre for Research in Epidemiology and Population Health (CESP), Institut pour la Santé et la Recherche Médicale (INSERM) U1018, Université Paris-Saclay, Villejuif, France
- 700 1_
- $a Perez-Cornago, Aurora $u Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
- 700 1_
- $a Sakoda, Lori C $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA $u Division of Research, Kaiser Permanente Northern California, Oakland, California, USA
- 700 1_
- $a Schumacher, Fredrick R $u Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA
- 700 1_
- $a Slattery, Martha L $u Department of Internal Medicine, University of Utah Health, Salt Lake City, Utah, USA
- 700 1_
- $a Toland, Amanda E $u Departments of Cancer Biology and Genetics and Internal Medicine, The Ohio State University, Columbus, Ohio, USA
- 700 1_
- $a van Duijnhoven, Fränzel J B $u Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands
- 700 1_
- $a Van Guelpen, Bethany $u Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden
- 700 1_
- $a Agudo, Antonio $u Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
- 700 1_
- $a Albanes, Demetrius $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
- 700 1_
- $a Alonso, M Henar $u Cancer Prevention and Control Program, Catalan Institute of Oncology - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain $u CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain $u Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
- 700 1_
- $a Anderson, Kristin $u Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
- 700 1_
- $a Arnau-Collell, Coral $u Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
- 700 1_
- $a Arndt, Volker $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany
- 700 1_
- $a Banbury, Barbara L $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Bassik, Michael C $u Department of Genetics, Stanford University, Stanford, California, USA
- 700 1_
- $a Berndt, Sonja I $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
- 700 1_
- $a Bézieau, Stéphane $u Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) de Nantes, Nantes, France
- 700 1_
- $a Bishop, D Timothy $u Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK
- 700 1_
- $a Boehm, Juergen $u Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah Health, Salt Lake City, Utah, USA
- 700 1_
- $a Boeing, Heiner $u Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany
- 700 1_
- $a Boutron-Ruault, Marie-Christine $u Centre for Research in Epidemiology and Population Health (CESP), Institut pour la Santé et la Recherche Médicale (INSERM) U1018, Université Paris-Saclay, Villejuif, France $u Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France
- 700 1_
- $a Brenner, Hermann $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany $u Division of Preventive Oncology, German Cancer Research Centre (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany $u German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany $1 https://orcid.org/0000000261291572
- 700 1_
- $a Brezina, Stefanie $u Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria
- 700 1_
- $a Buch, Stephan $u Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany
- 700 1_
- $a Buchanan, Daniel D $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia $u Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Clinical Pathology, The University of Melbourne, Melbourne, Victoria, Australia $u Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Melbourne, Victoria, Australia $1 https://orcid.org/0000000322256675
- 700 1_
- $a Burnett-Hartman, Andrea $u Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado, USA
- 700 1_
- $a Caan, Bette J $u Division of Research, Kaiser Permanente Medical Care Program, Oakland, California, USA
- 700 1_
- $a Campbell, Peter T $u Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia, USA
- 700 1_
- $a Carr, Prudence R $u Division of Clinical Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany
- 700 1_
- $a Castells, Antoni $u Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
- 700 1_
- $a Castellví-Bel, Sergi $u Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
- 700 1_
- $a Chan, Andrew T $u Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA $u Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA $u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA $u Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA $u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA $u Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA $1 https://orcid.org/0000000172846767
- 700 1_
- $a Chang-Claude, Jenny $u Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany $u Cancer Epidemiology Group, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany
- 700 1_
- $a Chanock, Stephen J $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
- 700 1_
- $a Curtis, Keith R $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a de la Chapelle, Albert $u Department of Cancer Biology and Genetics and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
- 700 1_
- $a Easton, Douglas F $u Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
- 700 1_
- $a English, Dallas R $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia $u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia
- 700 1_
- $a Feskens, Edith J M $u Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands
- 700 1_
- $a Gala, Manish $u Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA $u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
- 700 1_
- $a Gallinger, Steven J $u Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
- 700 1_
- $a Gauderman, W James $u Department of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
- 700 1_
- $a Giles, Graham G $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia $u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia
- 700 1_
- $a Goodman, Phyllis J $u SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Grady, William M $u Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA $u Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
- 700 1_
- $a Grove, John S $u University of Hawai'i Cancer Center, Honolulu, Hawaii, USA
- 700 1_
- $a Gsur, Andrea $u Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria $1 https://orcid.org/0000000297951528
- 700 1_
- $a Gunter, Marc J $u Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France
- 700 1_
- $a Haile, Robert W $u Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
- 700 1_
- $a Hampe, Jochen $u Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany $1 https://orcid.org/0000000224216127
- 700 1_
- $a Hoffmeister, Michael $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany $1 https://orcid.org/0000000283073197
- 700 1_
- $a Hopper, John L $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia $u Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea
- 700 1_
- $a Hsu, Wan-Ling $u Department of Biostatistics, University of Washington, Seattle, Washington, USA
- 700 1_
- $a Huang, Wen-Yi $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA $1 https://orcid.org/0000000244403368
- 700 1_
- $a Hudson, Thomas J $u Ontario Institute for Cancer Research, Toronto, Ontario, Canada
- 700 1_
- $a Jenab, Mazda $u Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France $1 https://orcid.org/0000000205731852
- 700 1_
- $a Jenkins, Mark A $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
- 700 1_
- $a Joshi, Amit D $u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA $u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA
- 700 1_
- $a Keku, Temitope O $u Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina, USA
- 700 1_
- $a Kooperberg, Charles $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Kühn, Tilman $u Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany
- 700 1_
- $a Küry, Sébastien $u Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) de Nantes, Nantes, France
- 700 1_
- $a Le Marchand, Loic $u University of Hawai'i Cancer Center, Honolulu, Hawaii, USA
- 700 1_
- $a Lejbkowicz, Flavio $u The Clalit Health Services, Personalized Genomic Service, Carmel Medical Center, Haifa, Israel $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel $u Clalit National Cancer Control Center, Haifa, Israel
- 700 1_
- $a Li, Christopher I $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Li, Li $u Department of Family Medicine, University of Virginia, Charlottesville, Virginia, USA
- 700 1_
- $a Lieb, Wolfgang $u Institute of Epidemiology, PopGen Biobank, Christian-Albrechts-University Kiel, Kiel, Germany
- 700 1_
- $a Lindblom, Annika $u Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden $u Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
- 700 1_
- $a Lindor, Noralane M $u Department of Health Science Research, Mayo Clinic, Scottsdale, Arizona, USA
- 700 1_
- $a Männistö, Satu $u Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland
- 700 1_
- $a Markowitz, Sanford D $u Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA
- 700 1_
- $a Milne, Roger L $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia $u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia
- 700 1_
- $a Moreno, Lorena $u Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain
- 700 1_
- $a Murphy, Neil $u Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France $1 https://orcid.org/0000000333478249
- 700 1_
- $a Nassir, Rami $u Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia
- 700 1_
- $a Offit, Kenneth $u Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA $u Department of Medicine, Weill Cornell Medical College, New York, New York, USA
- 700 1_
- $a Ogino, Shuji $u Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA $u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA $u Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA $u Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
- 700 1_
- $a Panico, Salvatore $u Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, Naples, Italy
- 700 1_
- $a Parfrey, Patrick S $u Clinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
- 700 1_
- $a Pearlman, Rachel $u Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA
- 700 1_
- $a Pharoah, Paul D P $u Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
- 700 1_
- $a Phipps, Amanda I $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA $u Department of Epidemiology, University of Washington, Seattle, Washington, USA
- 700 1_
- $a Platz, Elizabeth A $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
- 700 1_
- $a Potter, John D $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Prentice, Ross L $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Qi, Lihong $u Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, California, USA
- 700 1_
- $a Raskin, Leon $u Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
- 700 1_
- $a Rennert, Gad $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel $u Clalit National Cancer Control Center, Haifa, Israel $u Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
- 700 1_
- $a Rennert, Hedy S $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel $u Clalit National Cancer Control Center, Haifa, Israel $u Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
- 700 1_
- $a Riboli, Elio $u School of Public Health, Imperial College London, London, UK
- 700 1_
- $a Schafmayer, Clemens $u Department of General Surgery, University Hospital Rostock, Rostock, Germany
- 700 1_
- $a Schoen, Robert E $u Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
- 700 1_
- $a Seminara, Daniela $u Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
- 700 1_
- $a Song, Mingyang $u Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA $u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA $u Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA
- 700 1_
- $a Su, Yu-Ru $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Tangen, Catherine M $u SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Thibodeau, Stephen N $u Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, MayoClinic, Rochester, Minnesota, USA
- 700 1_
- $a Thomas, Duncan C $u Department of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
- 700 1_
- $a Trichopoulou, Antonia $u Hellenic Health Foundation, Athens, Greece $u WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
- 700 1_
- $a Ulrich, Cornelia M $u Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah Health, Salt Lake City, Utah, USA
- 700 1_
- $a Visvanathan, Kala $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
- 700 1_
- $a Vodicka, Pavel $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
- 700 1_
- $a Vodickova, Ludmila $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
- 700 1_
- $a Vymetalkova, Veronika $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
- 700 1_
- $a Weigl, Korbinian $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany $u German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany $u Medical Faculty, University of Heidelberg, Heidelberg, Germany
- 700 1_
- $a Weinstein, Stephanie J $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
- 700 1_
- $a White, Emily $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
- 700 1_
- $a Wolk, Alicja $u Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
- 700 1_
- $a Woods, Michael O $u Discipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland, Canada
- 700 1_
- $a Wu, Anna H $u Department of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
- 700 1_
- $a Abecasis, Goncalo R $u Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
- 700 1_
- $a Nickerson, Deborah A $u Department of Genome Sciences, University of Washington, Seattle, Washington, USA
- 700 1_
- $a Scacheri, Peter C $u Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA
- 700 1_
- $a Kundaje, Anshul $u Department of Genetics, Stanford University, Stanford, California, USA $u Department of Computer Science, Stanford University, Stanford, California, USA
- 700 1_
- $a Casey, Graham $u Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
- 700 1_
- $a Gruber, Stephen B $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA $u City of Hope National Medical Center, Duarte, California, USA
- 700 1_
- $a Hsu, Li $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA $u Department of Biostatistics, University of Washington, Seattle, Washington, USA
- 700 1_
- $a Moreno, Victor $u Cancer Prevention and Control Program, Catalan Institute of Oncology - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain $u CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain $u Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
- 700 1_
- $a Hayes, Richard B $u Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York, USA
- 700 1_
- $a Newcomb, Polly A $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA $u Department of Epidemiology, University of Washington, Seattle, Washington, USA
- 700 1_
- $a Peters, Ulrike $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA upeters@fhcrc.org $u Department of Epidemiology, University of Washington, Seattle, Washington, USA $1 https://orcid.org/0000000156669318
- 773 0_
- $w MED00009778 $t Gut $x 1468-3288 $g Roč. 70, č. 7 (2021), s. 1325-1334
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33632709 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220425 $b ABA008
- 991 __
- $a 20220506130510 $b ABA008
- 999 __
- $a ok $b bmc $g 1789799 $s 1163564
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2021 $b 70 $c 7 $d 1325-1334 $e 20210225 $i 1468-3288 $m Gut $n Gut $x MED00009778
- GRA __
- $a P01 CA087969 $p NCI NIH HHS $2 United States
- GRA __
- $a P30 CA015704 $p NCI NIH HHS $2 United States
- GRA __
- $a U01 CA137088 $p NCI NIH HHS $2 United States
- GRA __
- $a U01 CA164930 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN268201200008C $p NHLBI NIH HHS $2 United States
- GRA __
- $a R01 CA201407 $p NCI NIH HHS $2 United States
- GRA __
- $a UM1 CA186107 $p NCI NIH HHS $2 United States
- GRA __
- $a R01 CA207371 $p NCI NIH HHS $2 United States
- GRA __
- $a R01 CA042182 $p NCI NIH HHS $2 United States
- GRA __
- $a R01 CA059045 $p NCI NIH HHS $2 United States
- GRA __
- $a R35 CA197735 $p NCI NIH HHS $2 United States
- GRA __
- $a U10 CA037429 $p NCI NIH HHS $2 United States
- GRA __
- $a U01 CA182883 $p NCI NIH HHS $2 United States
- GRA __
- $a UG1 CA189974 $p NCI NIH HHS $2 United States
- GRA __
- $a R01 CA151993 $p NCI NIH HHS $2 United States
- GRA __
- $a R21 CA191312 $p NCI NIH HHS $2 United States
- GRA __
- $a U01 CA206110 $p NCI NIH HHS $2 United States
- GRA __
- $a P30 CA008748 $p NCI NIH HHS $2 United States
- GRA __
- $a U01 CA167551 $p NCI NIH HHS $2 United States
- GRA __
- $a UM1 CA182883 $p NCI NIH HHS $2 United States
- GRA __
- $a K07 CA190673 $p NCI NIH HHS $2 United States
- GRA __
- $a HHSN268201200008I $p NHLBI NIH HHS $2 United States
- GRA __
- $a P30 CA071789 $p NCI NIH HHS $2 United States
- LZP __
- $a Pubmed-20220425
