Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

The LOTUS initiative for open knowledge management in natural products research

A. Rutz, M. Sorokina, J. Galgonek, D. Mietchen, E. Willighagen, A. Gaudry, JG. Graham, R. Stephan, R. Page, J. Vondrášek, C. Steinbeck, GF. Pauli, JL. Wolfender, J. Bisson, PM. Allard

. 2022 ; 11 (-) : . [pub] 20220526

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22018313

Grantová podpora
P50 AT000155 NCCIH NIH HHS - United States
U41 AT008706 NCCIH NIH HHS - United States

Contemporary bioinformatic and chemoinformatic capabilities hold promise to reshape knowledge management, analysis and interpretation of data in natural products research. Currently, reliance on a disparate set of non-standardized, insular, and specialized databases presents a series of challenges for data access, both within the discipline and for integration and interoperability between related fields. The fundamental elements of exchange are referenced structure-organism pairs that establish relationships between distinct molecular structures and the living organisms from which they were identified. Consolidating and sharing such information via an open platform has strong transformative potential for natural products research and beyond. This is the ultimate goal of the newly established LOTUS initiative, which has now completed the first steps toward the harmonization, curation, validation and open dissemination of 750,000+ referenced structure-organism pairs. LOTUS data is hosted on Wikidata and regularly mirrored on https://lotus.naturalproducts.net. Data sharing within the Wikidata framework broadens data access and interoperability, opening new possibilities for community curation and evolving publication models. Furthermore, embedding LOTUS data into the vast Wikidata knowledge graph will facilitate new biological and chemical insights. The LOTUS initiative represents an important advancement in the design and deployment of a comprehensive and collaborative natural products knowledge base.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22018313
003      
CZ-PrNML
005      
20220804134708.0
007      
ta
008      
220720s2022 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.7554/eLife.70780 $2 doi
035    __
$a (PubMed)35616633
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Rutz, Adriano $u School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland $u Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland $1 https://orcid.org/0000000304439902
245    14
$a The LOTUS initiative for open knowledge management in natural products research / $c A. Rutz, M. Sorokina, J. Galgonek, D. Mietchen, E. Willighagen, A. Gaudry, JG. Graham, R. Stephan, R. Page, J. Vondrášek, C. Steinbeck, GF. Pauli, JL. Wolfender, J. Bisson, PM. Allard
520    9_
$a Contemporary bioinformatic and chemoinformatic capabilities hold promise to reshape knowledge management, analysis and interpretation of data in natural products research. Currently, reliance on a disparate set of non-standardized, insular, and specialized databases presents a series of challenges for data access, both within the discipline and for integration and interoperability between related fields. The fundamental elements of exchange are referenced structure-organism pairs that establish relationships between distinct molecular structures and the living organisms from which they were identified. Consolidating and sharing such information via an open platform has strong transformative potential for natural products research and beyond. This is the ultimate goal of the newly established LOTUS initiative, which has now completed the first steps toward the harmonization, curation, validation and open dissemination of 750,000+ referenced structure-organism pairs. LOTUS data is hosted on Wikidata and regularly mirrored on https://lotus.naturalproducts.net. Data sharing within the Wikidata framework broadens data access and interoperability, opening new possibilities for community curation and evolving publication models. Furthermore, embedding LOTUS data into the vast Wikidata knowledge graph will facilitate new biological and chemical insights. The LOTUS initiative represents an important advancement in the design and deployment of a comprehensive and collaborative natural products knowledge base.
650    12
$a biologické přípravky $7 D001688
650    _2
$a výpočetní biologie $7 D019295
650    _2
$a databáze faktografické $7 D016208
650    _2
$a znalosti $7 D019359
650    12
$a management znalostí $7 D058436
655    _2
$a časopisecké články $7 D016428
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Sorokina, Maria $u Institute for Inorganic and Analytical Chemistry, Friedrich-Schiller-University Jena, Jena, Germany $1 https://orcid.org/0000000193597149
700    1_
$a Galgonek, Jakub $u Institute of Organic Chemistry and Biochemistry of the CAS, Prague, Czech Republic $1 https://orcid.org/000000027038544X
700    1_
$a Mietchen, Daniel $u Ronin Institute, Montclair, United States $u Leibniz Institute of Freshwater Ecology and Inland Fisheries, Berlin, Germany $u School of Data Science, University of Virginia, Charlottesville, United States $1 https://orcid.org/0000000194881870
700    1_
$a Willighagen, Egon $u Department of Bioinformatics-BiGCaT, Maastricht University, Maastricht, Netherlands $1 https://orcid.org/0000000175420286
700    1_
$a Gaudry, Arnaud $u School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland $u Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland $1 https://orcid.org/0000000236487362
700    1_
$a Graham, James G $u Center for Natural Product Technologies and WHO Collaborating Centre for Traditional Medicine (WHO CC/TRM), Pharmacognosy Institute; College of Pharmacy, University of Illinois at Chicago, Chicago, United States $u Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, United States
700    1_
$a Stephan, Ralf $u Ontario Institute for Cancer Research (OICR), University Ave Suite, Toronto, Canada $1 https://orcid.org/000000024650631X
700    1_
$a Page, Roderic $u University of Glasgow, Glasgow, United Kingdom $1 https://orcid.org/0000000271019767
700    1_
$a Vondrášek, Jiří $u Institute of Organic Chemistry and Biochemistry of the CAS, Prague, Czech Republic $1 https://orcid.org/000000026066973X $7 jo2005274206
700    1_
$a Steinbeck, Christoph $u Institute for Inorganic and Analytical Chemistry, Friedrich-Schiller-University Jena, Jena, Germany $1 https://orcid.org/0000000169660814
700    1_
$a Pauli, Guido F $u Center for Natural Product Technologies and WHO Collaborating Centre for Traditional Medicine (WHO CC/TRM), Pharmacognosy Institute; College of Pharmacy, University of Illinois at Chicago, Chicago, United States $u Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, United States $1 https://orcid.org/0000000310224326
700    1_
$a Wolfender, Jean-Luc $u School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland $u Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland $1 https://orcid.org/000000020125952X
700    1_
$a Bisson, Jonathan $u Center for Natural Product Technologies and WHO Collaborating Centre for Traditional Medicine (WHO CC/TRM), Pharmacognosy Institute; College of Pharmacy, University of Illinois at Chicago, Chicago, United States $u Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, United States $1 https://orcid.org/0000000316409989
700    1_
$a Allard, Pierre-Marie $u School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland $u Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland $u Department of Biology, University of Fribourg, Fribourg, Switzerland $1 https://orcid.org/0000000333892191
773    0_
$w MED00188753 $t eLife $x 2050-084X $g Roč. 11, č. - (2022)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35616633 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220720 $b ABA008
991    __
$a 20220804134702 $b ABA008
999    __
$a ok $b bmc $g 1822084 $s 1169556
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 11 $c - $e 20220526 $i 2050-084X $m eLife $n eLife $x MED00188753
GRA    __
$a P50 AT000155 $p NCCIH NIH HHS $2 United States
GRA    __
$a U41 AT008706 $p NCCIH NIH HHS $2 United States
LZP    __
$a Pubmed-20220720

Najít záznam

Citační ukazatele

Možnosti archivace