-
Je něco špatně v tomto záznamu ?
Liquid resorbable nanofibrous surgical mesh: a proof of a concept
B. East, J. Woleský, R. Divín, M. Otáhal, K. Vocetková, V. Sovková, VH. Blahnová, M. Koblížek, P. Kubový, A. Nečasová, A. Staffa, AC. de Beaux, J. Lorenzová, E. Amler
Jazyk angličtina Země Francie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
ProQuest Central
od 1999-06-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2003-03-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1999-06-01 do Před 1 rokem
- MeSH
- břišní stěna * chirurgie MeSH
- chirurgické síťky škodlivé účinky MeSH
- incizní kýla * chirurgie MeSH
- králíci MeSH
- lidé MeSH
- nanovlákna * MeSH
- operace kýly metody MeSH
- šicí techniky škodlivé účinky MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: Surgical mesh is widely used not only to treat but also to prevent incisional hernia formation. Despite much effort by material engineers, the 'ideal' mesh mechanically, biologically and surgically easy to use remains elusive. Advances in tissue engineering and nanomedicine have allowed new concepts to be tested with promising results in both small and large animals. Abandoning the concept of a pre-formed mesh completely for a 'pour in liquid mesh' has never been tested before. MATERIALS AND METHODS: Thirty rabbits underwent midline laparotomy with closure using an absorbable suture and small stitch small bites technique. In addition, their abdominal wall closure was reinforced by a liquid nanofibrous scaffold composed of a fibrin sealant and nanofibres of poly-ε-caprolactone with or without hyaluronic acid or the sealant alone, poured in as an 'onlay' over the closed abdominal wall. The animals were killed at 6 weeks and their abdominal wall was subjected to histological and biomechanical evaluations. RESULTS: All the animals survived the study period with no major complication. Histological evaluation showed an eosinophilic infiltration in all groups and foreign body reaction more pronounced in the groups with nanofibres. Biomechanical testing demonstrated that groups treated with nanofibres developed a scar with higher tensile yield strength. CONCLUSION: The use of nanofibres in a liquid form applied to the closed abdominal wall is easy to use and improves the biomechanical properties of healing fascia at 6 weeks after midline laparotomy in a rabbit model.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22018969
- 003
- CZ-PrNML
- 005
- 20220804135227.0
- 007
- ta
- 008
- 220720s2022 fr f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s10029-022-02582-1 $2 doi
- 035 __
- $a (PubMed)35377083
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a fr
- 100 1_
- $a East, B $u 3rd Department of Surgery, 1st Faculty of Medicine, Motol University Hospital, V uvalu 84, 150 06, Prague, Czech Republic. Barbora.east@gmail.com $1 https://orcid.org/0000000301121747
- 245 10
- $a Liquid resorbable nanofibrous surgical mesh: a proof of a concept / $c B. East, J. Woleský, R. Divín, M. Otáhal, K. Vocetková, V. Sovková, VH. Blahnová, M. Koblížek, P. Kubový, A. Nečasová, A. Staffa, AC. de Beaux, J. Lorenzová, E. Amler
- 520 9_
- $a BACKGROUND: Surgical mesh is widely used not only to treat but also to prevent incisional hernia formation. Despite much effort by material engineers, the 'ideal' mesh mechanically, biologically and surgically easy to use remains elusive. Advances in tissue engineering and nanomedicine have allowed new concepts to be tested with promising results in both small and large animals. Abandoning the concept of a pre-formed mesh completely for a 'pour in liquid mesh' has never been tested before. MATERIALS AND METHODS: Thirty rabbits underwent midline laparotomy with closure using an absorbable suture and small stitch small bites technique. In addition, their abdominal wall closure was reinforced by a liquid nanofibrous scaffold composed of a fibrin sealant and nanofibres of poly-ε-caprolactone with or without hyaluronic acid or the sealant alone, poured in as an 'onlay' over the closed abdominal wall. The animals were killed at 6 weeks and their abdominal wall was subjected to histological and biomechanical evaluations. RESULTS: All the animals survived the study period with no major complication. Histological evaluation showed an eosinophilic infiltration in all groups and foreign body reaction more pronounced in the groups with nanofibres. Biomechanical testing demonstrated that groups treated with nanofibres developed a scar with higher tensile yield strength. CONCLUSION: The use of nanofibres in a liquid form applied to the closed abdominal wall is easy to use and improves the biomechanical properties of healing fascia at 6 weeks after midline laparotomy in a rabbit model.
- 650 12
- $a břišní stěna $x chirurgie $7 D034861
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a operace kýly $x metody $7 D059685
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a incizní kýla $x chirurgie $7 D000069290
- 650 12
- $a nanovlákna $7 D057139
- 650 _2
- $a králíci $7 D011817
- 650 _2
- $a chirurgické síťky $x škodlivé účinky $7 D013526
- 650 _2
- $a šicí techniky $x škodlivé účinky $7 D013536
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Woleský, J $u 3rd Department of Surgery, 1st Faculty of Medicine, Motol University Hospital, V uvalu 84, 150 06, Prague, Czech Republic
- 700 1_
- $a Divín, R $u Department of Biophysics, 2nd Faculty of Medicine, Charles University, V uvalu 84, 150 06, Prague, Czech Republic $u University Centre for Energy Efficient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Buštěhrad, Czech Republic
- 700 1_
- $a Otáhal, M $u Department of Natural Sciences, Faculty of Biomedical Engineering, Czech Technical University in Prague, Sitna 3105, 272 01, Kladno, Czech Republic $u Department of Anatomy and Biomechanics, Faculty of Physical Education and Sport, Charles University in Prague, Jose Martího 31, 162 52, Prague 6, Czech Republic
- 700 1_
- $a Vocetková, K $u University Centre for Energy Efficient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Buštěhrad, Czech Republic $u Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic
- 700 1_
- $a Sovková, V $u University Centre for Energy Efficient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Buštěhrad, Czech Republic $u Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic
- 700 1_
- $a Blahnová, V H $u Department of Biophysics, 2nd Faculty of Medicine, Charles University, V uvalu 84, 150 06, Prague, Czech Republic $u University Centre for Energy Efficient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Buštěhrad, Czech Republic $u Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20, Prague, Czech Republic
- 700 1_
- $a Koblížek, M $u Department of Pathology, 2nd Faculty of Medicine, Motol University Hospital, Charles University, V uvalu, 15006, Prague, Czech Republic
- 700 1_
- $a Kubový, P $u Department of Anatomy and Biomechanics, Faculty of Physical Education and Sport, Charles University in Prague, Jose Martího 31, 162 52, Prague 6, Czech Republic
- 700 1_
- $a Nečasová, A $u Department of Surgery & Orthopaedics, Faculty of Veterinary Medicine, Small Animal Clinic, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
- 700 1_
- $a Staffa, A $u Large Animal Clinical Laboratory, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
- 700 1_
- $a de Beaux, A Ch $u Royal Infirmary, Department of General Surgery, 51 Little France Crescent, Old Dalkeith Rd, Edinburgh, EH16 4SA, UK
- 700 1_
- $a Lorenzová, J $u Department of Surgery & Orthopaedics, Faculty of Veterinary Medicine, Small Animal Clinic, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
- 700 1_
- $a Amler, E $u Department of Biophysics, 2nd Faculty of Medicine, Charles University, V uvalu 84, 150 06, Prague, Czech Republic $u University Centre for Energy Efficient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43, Buštěhrad, Czech Republic
- 773 0_
- $w MED00005723 $t Hernia : the journal of hernias and abdominal wall surgery $x 1248-9204 $g Roč. 26, č. 2 (2022), s. 557-565
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35377083 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220720 $b ABA008
- 991 __
- $a 20220804135220 $b ABA008
- 999 __
- $a ok $b bmc $g 1822526 $s 1170212
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 26 $c 2 $d 557-565 $e 20220404 $i 1248-9204 $m Hernia $n Hernia $x MED00005723
- LZP __
- $a Pubmed-20220720
