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New insights into the genetic etiology of Alzheimer's disease and related dementias

C. Bellenguez, F. Küçükali, IE. Jansen, L. Kleineidam, S. Moreno-Grau, N. Amin, AC. Naj, R. Campos-Martin, B. Grenier-Boley, V. Andrade, PA. Holmans, A. Boland, V. Damotte, SJ. van der Lee, MR. Costa, T. Kuulasmaa, Q. Yang, I. de Rojas, JC. Bis,...

. 2022 ; 54 (4) : 412-436. [pub] 20220404

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural

Perzistentní odkaz   https://www.medvik.cz/link/bmc22019033

Grantová podpora
N01HC55222 NHLBI NIH HHS - United States
R01 NS080820 NINDS NIH HHS - United States
P30 AG013854 NIA NIH HHS - United States
P30 AG053760 NIA NIH HHS - United States
K08 AG065463 NIA NIH HHS - United States
MR/R024804/1 Medical Research Council - United Kingdom
R01 HL103612 NHLBI NIH HHS - United States
N01HC85080 NHLBI NIH HHS - United States
G0801418/1 Medical Research Council - United Kingdom
R01 AG022374 NIA NIH HHS - United States
P50 AG023501 NIA NIH HHS - United States
U01 AG046152 NIA NIH HHS - United States
P30 AG010124 NIA NIH HHS - United States
U01 HG006375 NHGRI NIH HHS - United States
U01 AG058654 NIA NIH HHS - United States
R01 NS017950 NINDS NIH HHS - United States
RC2 AG036528 NIA NIH HHS - United States
MR/L023784/1 Medical Research Council - United Kingdom
R01 AG054005 NIA NIH HHS - United States
P30 AG028377 NIA NIH HHS - United States
Wellcome Trust - United Kingdom
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R01 HL120393 NHLBI NIH HHS - United States
P50 AG005142 NIA NIH HHS - United States
RF1 AG059421 NIA NIH HHS - United States
R01 AG035137 NIA NIH HHS - United States
R01 AG009029 NIA NIH HHS - United States
HHSN268201800001C NHLBI NIH HHS - United States
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P30 AG010133 NIA NIH HHS - United States
U24 AG021886 NIA NIH HHS - United States
R01 AG031581 NIA NIH HHS - United States
R01 AG009956 NIA NIH HHS - United States
U01 HL080295 NHLBI NIH HHS - United States
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T32 EY007157 NEI NIH HHS - United States
HHSN268201200036C NHLBI NIH HHS - United States
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U01 AG061356 NIA NIH HHS - United States
K99 AG066849 NIA NIH HHS - United States
RC2 AG036650 NIA NIH HHS - United States
R01 AG019085 NIA NIH HHS - United States
U01 HG008657 NHGRI NIH HHS - United States
U01 HL130114 NHLBI NIH HHS - United States
R56 AG055824 NIA NIH HHS - United States
U01 AG032984 NIA NIH HHS - United States
R01 AG013616 NIA NIH HHS - United States
R01 AG030146 NIA NIH HHS - United States
U01 AG024904 NIA NIH HHS - United States
P20 MD000546 NIMHD NIH HHS - United States
75N92021D00006 NHLBI NIH HHS - United States
P50 AG008702 NIA NIH HHS - United States
R01 AG017173 NIA NIH HHS - United States
UL1 RR029893 NCRR NIH HHS - United States
Howard Hughes Medical Institute - United States
Department of Health - United Kingdom
U01 AG016976 NIA NIH HHS - United States
P50 NS039764 NINDS NIH HHS - United States
P01 AG003991 NIA NIH HHS - United States
P30 AG008051 NIA NIH HHS - United States
P50 AG005681 NIA NIH HHS - United States
P30 AG013846 NIA NIH HHS - United States
RC2 AG036502 NIA NIH HHS - United States
P01 AG026276 NIA NIH HHS - United States
R01 AG017917 NIA NIH HHS - United States
R01 HL087652 NHLBI NIH HHS - United States
MR/L501517/1 Medical Research Council - United Kingdom
R01 MH080295 NIMH NIH HHS - United States
N01HC85082 NHLBI NIH HHS - United States
MR/K013041/1 Medical Research Council - United Kingdom
R01 AG028786 NIA NIH HHS - United States
KL2 RR024151 NCRR NIH HHS - United States
R01 AG049607 NIA NIH HHS - United States
P50 AG005136 NIA NIH HHS - United States
P30 AG012300 NIA NIH HHS - United States
R21 AG063130 NIA NIH HHS - United States
R01 HL105756 NHLBI NIH HHS - United States
R01 AG037985 NIA NIH HHS - United States
HHSN268201500001I NHLBI NIH HHS - United States
R01 AG012101 NIA NIH HHS - United States
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U01 DK066134 NIDDK NIH HHS - United States
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P30 DK063491 NIDDK NIH HHS - United States
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CIHR - Canada
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U24 AG041689 NIA NIH HHS - United States
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MR/L501529/1 Medical Research Council - United Kingdom
N01HC85079 NHLBI NIH HHS - United States
R01 AG036042 NIA NIH HHS - United States
P30 AG010161 NIA NIH HHS - United States
R01 AG033193 NIA NIH HHS - United States
R01 AG032990 NIA NIH HHS - United States
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R01 CA129769 NCI NIH HHS - United States
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E-zdroje Online Plný text

NLK ProQuest Central od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 2000-01-01 do Před 1 rokem

Odkazy

PubMed 35379992
DOI 10.1038/s41588-022-01024-z
Knihovny.cz E-zdroje

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.

1st Department of Neurology Aiginition Hospital National and Kapodistrian University of Athens Medical School Athens Greece

1st Department of Neurology Medical School Aristotle University of Thessaloniki Thessaloniki Greece

Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden

AI Virtanen Institute for Molecular Sciences University of Eastern Finland Kuopio Finland

Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands

Alzheimer Hellas Thessaloniki Greece

Alzheimer Research Center and Memory Clinic Andalusian Institute for Neuroscience Málaga Spain

Alzheimer's Disease and Other Cognitive Disorders Unit Neurology Department Hospital Clinic Barcelona Spain

Athens Association of Alzheimer's Disease and Related Disorders Athens Greece

Azienda Ospedaliero Universitaria Careggi Florence Italy

Bioinformatics College of Life Sciences Brigham Young University Provo UT USA

Biosciences School of Science and Technology Nottingham Trent University Nottingham UK

Biostatistics University of Kentucky College of Public Health Lexington KY USA

Bordeaux Population Health Research Center University Bordeaux INSERM Bordeaux France

Boston University and the NHLBI's Framingham Heart Study Boston MA USA

Brain Institute Federal University of Rio Grande do Norte Natal Brazil

CAEBI Centro Andaluz de Estudios Bioinformáticos Sevilla Spain

Cardiff School of Medicine Cardiff University Cardiff UK

Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle WA USA

CEA Centre National de Recherche en Génomique Humaine Université Paris Saclay Evry France

Center for Alzheimer Research Department NVS Division of Neurogeriatrics Karolinska Institutet Stockholm Sweden

Center for Neurosciences Vrije Universiteit Brussel Brussels Belgium

Center of Mental Health Clinic and Policlinic of Psychiatry Psychosomatics and Psychotherapy University Hospital of Würzburg Wuerzburg Germany

Centre for Healthy Brain Ageing School of Psychiatry Faculty of Medicine University of New South Wales Sydney New South Wales Australia

Centre for Memory Disturbances Lab of Clinical Neurochemistry Section of Neurology University of Perugia Perugia Italy

Centre for Neurodegenerative Disorders Department of Clinical and Experimental Sciences University of Brescia Brescia Italy

Centre of Age Related Medicine Stavanger University Hospital Stavanger Norway

Centro de Biología Molecular Severo Ochoa Madrid Spain

Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM Hospital Clínico San Carlos Madrid Spain

Centro de Neuropsiquiatría y Neurología de la Conducta C A B A Buenos Aires Argentina

CHUV Old Age Psychiatry Department of Psychiatry Lausanne Switzerland

CIBERNED Network Center for Biomedical Research in Neurodegenerative Diseases National Institute of Health Carlos 3 Madrid Spain

CIEN Foundation Queen Sofia Foundation Alzheimer Center Madrid Spain

Cleveland Institute for Computational Biology Case Western Reserve University Cleveland OH USA

Clinic of Neurology UH 'Alexandrovska' Medical University Sofia Sofia Bulgaria

Clinical and Experimental Science Faculty of Medicine University of Southampton Southampton UK

Complex Genetics of Alzheimer's Disease Group VIB Center for Molecular Neurology VIB Antwerp Belgium

Delft Bioinformatics Lab Delft University of Technology Delft the Netherlands

Dementia Centre for Research Collaboration School of Psychiatry University of New South Wales Sydney New South Wales Australia

Dementia Research Centre UCL Queen Square Institute of Neurology London UK

Departamento Ciencias Fisiológicas UAII Facultad de Medicina UBA C A B A Buenos Aires Argentina

Departamento de Especialidades Quirúrgicas Bioquímicas e Inmunología School of Medicine University of Málaga Málaga Spain

Department of Biology Brigham Young University Provo UT USA

Department of Biomedical Sciences Section of Neuroscience and Clinical Pharmacology University of Cagliari Cagliari Italy

Department of Biomedical Sciences University of Antwerp Antwerp Belgium

Department of Biomedical Sciences University of Cagliari Cagliari Italy

Department of Biostatistics Boston University School of Public Health Boston MA USA

Department of Biostatistics Epidemiology and Informatics Penn Neurodegeneration Genomics Center University of Pennsylvania Perelman School of Medicine Philadelphia PA USA

Department of Biostatistics Epidemiology and Informatics Perelman School of Medicine University of Pennsylvania Philadelphia PA USA

Department of Child and Adolescent Psychiatry and Psychotherapy University Hospital of Psychiatry Zurich University of Zurich Zurich Switzerland

Department of Clinical Biochemistry Herlev and Gentofte Hospital Herlev Denmark

Department of Clinical Biochemistry Rigshospitalet Copenhagen Denmark

Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

Department of Clinical Sciences and Community Health University of Milan Milan Italy

Department of Complex Trait Genetics Center for Neurogenomics and Cognitive Research Amsterdam Neuroscience Vrije University Amsterdam the Netherlands

Department of Epidemiology Erasmus MC Rotterdam the Netherlands

Department of Epidemiology University of Washington Seattle WA USA

Department of Genetics and CNR MAJ Normandie University UNIROUEN INSERM U1245 CHU Rouen Rouen France

Department of Genetics and Genomic Sciences and Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai New York NY USA

Department of Genetics and Genomic Sciences Ronald M Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai New York NY USA

Department of Geriatric Medicine Oslo University Hospital Oslo Norway

Department of Geriatric Psychiatry Central Institute for Mental Health Mannheim University of Heidelberg Heidelberg Germany

Department of Geriatric Psychiatry University Hospital of Psychiatry Zürich Zürich Switzerland

Department of Geriatrics St Olav's Hospital Trondheim University Hospital Trondheim Norway

Department of Health Service University of Washington Seattle WA USA

Department of Immunology Hospital Universitario Doctor Negrín Las Palmas de Gran Canaria Las Palmas Spain

Department of Internal Medicine and Biostatistics Erasmus MC Rotterdam the Netherlands

Department of Laboratory Diagnostics 3 Laboratory of Analysis Brescia Hospital Brescia Italy

Department of Medical and Molecular Genetics Indiana University Indianapolis IN USA

Department of Medicine Boston University School of Medicine Boston MA USA

Department of Medicine University of Washington Seattle WA USA

Department of Neurodegenerative Diseases and Geriatric Psychiatry University Hospital Bonn Bonn Germany

Department of Neurology 2 B Sant Pau Hospital de la Santa Creu i Sant Pau Universitat Autònoma de Barcelona Barcelona Spain

Department of Neurology and Clinical Neurophysiology University Hospital of Trondheim Trondheim Norway

Department of Neurology and CNR MAJ F 76000 Normandy Center for Genomic and Personalized Medicine Normandie University UNIROUEN INSERM U1245 CHU Rouen Rouen France

Department of Neurology Boston University School of Medicine Boston MA USA

Department of Neurology Columbia University New York NY USA

Department of Neurology Erasmus MC Rotterdam the Netherlands

Department of Neurology ErasmusMC Rotterdam the Netherlands

Department of Neurology Hospital Universitario Donostia OSAKIDETZA Servicio Vasco de Salud San Sebastian Spain

Department of Neurology Kuopio University Hospital Kuopio Finland

Department of Neurology Medical School University of Cyprus Nicosia Cyprus

Department of Neurology UMC Utrecht Brain Center Utrecht the Netherlands

Department of Neurology University Medical Center Groningen Groningen the Netherlands

Department of Neurology University of Bonn Bonn Germany

Department of Neurology UZ Brussel Brussels Belgium

Department of Neuromedicine and Movement Science Norwegian University of Science and Technology Trondheim Norway

Department of Neuropsychiatry and Laboratory of Molecular Psychiatry Charité Charitéplatz 1 Berlin Germany

Department of Neuroscience and Mental Health AOU Città della Salute e della Scienza di Torino Torino Italy

Department of Neuroscience Catholic University of Sacred Heart Fondazione Policlinico Universitario A Gemelli IRCCS Rome Italy

Department of Neuroscience Psychology Drug Research and Child Health University of Florence Florence Italy

Department of Neuroscience Rita Levi Montalcini University of Torino Torino Italy

Department of Neurosciences University of Helsinki and Department of Geriatrics Helsinki University Hospital Helsinki Finland

Department of Nutrition and Diatetics Harokopio University Athens Greece

Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA

Department of Pathology and Laboratory Medicine University of Pennsylvania Philadelphia PA USA

Department of Population and Quantitative Health Sciences Case Western Reserve University Cleveland OH USA

Department of Primary Medical Care University Medical Centre Hamburg Eppendorf Hamburg Germany

Department of Psychiatry and Neuropsychologie Maastricht University Alzheimer Center Limburg Maastricht the Netherlands

Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria

Department of Psychiatry and Psychotherapy Universitätsklinikum Erlangen and Friedrich Alexander Universität Erlangen Nürnberg Erlangen Germany

Department of Psychiatry and Psychotherapy University Medical Center Goettingen Goettingen Germany

Department of Psychiatry Harvard Medical School McLean Hospital Belmont MA USA

Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA

Department of Psychiatry Namsos Hospital Namsos Norway

Department of Psychiatry Psychosomatics and Psychotherapy Center of Mental Health University Hospital Wuerzburg Germany

Department of Psychiatry Social Medicine Center East Donauspital Vienna Austria

Department of Public Health and Carins Sciences Geriatrics Uppsala University Uppsala Sweden

Department of Research and Innovation Helse Fonna Haugesund Hospital Haugesund Norway

Department of Surgery Biochemistry and Molecular Biology School of Medicine University of Málaga Málaga Spain

Departments of Neurology and Epidemiology University of Washington Seattle WA USA

Depatamento de Especialidades Quirúrgicas Bioquímica e Inmunología Facultad de Medicina Universidad de Málaga Málaga Spain

DIMEC University of Parma Parma Italy

Division of Clinical Geriatrics Center for Alzheimer Research Care Sciences and Society Karolinska Institutet Stockholm Sweden

Division of Genetic Medicine Vanderbilt University Nashville TN USA

Division of Neurogenetics and Molecular Psychiatry Department of Psychiatry and Psychotherapy University of Cologne Medical Faculty Cologne Germany

Dr John T Macdonald Foundation Department of Human Genetics University of Miami Miami FL USA

EA 4468 Université de Paris APHP Hôpital Broca Paris France

Estelle and Daniel Maggin Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA

Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases University of Cologne Cologne Germany

Experimental Neuro psychobiology Laboratory Department of Clinical and Behavioral Neurology IRCCS Santa Lucia Foundation Rome Italy

Faculty of Medical and Health Sciences University of Auckland Auckland New Zealand

Faculty of Medicine University of Lisbon Lisbon Portugal

Fondazione IRCCS Ca'Granda Ospedale Policlinico Milan Italy

Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy

Framingham Heart Study Framingham MA USA

Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit Department of Neurology University Hospital MútuaTerrassa Terrassa Spain

Fundación Pública Galega de Medicina Xenómica CIBERER IDIS University of Santiago de Compostela Santiago de Compostela Spain

Geriatic Unit Fondazione Cà Granda IRCCS Ospedale Maggiore Policlinico Milan Italy

Geriatrics Unit Fondazione Policlinico A Gemelli IRCCS Rome Italy

German Center for Neurodegenerative Diseases Berlin Germany

German Center for Neurodegenerative Diseases Bonn Germany

German Center for Neurodegenerative Diseases Goettingen Germany

German Center for Neurodegenerative Diseases Magdeburg Germany

German Center for Neurodegenerative Diseases Munich Germany

Gertrude H Sergievsky Center Columbia University New York NY USA

Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases University of Texas Health Sciences Center San Antonio TX USA

GRC 21 Alzheimer Precision Medicine Initiative Sorbonne University AP HP Pitié Salpêtrière Hospital Paris France

Grupo de Medicina Xenómica Centro Nacional de Genotipado Universidade de Santiago de Compostela Santiago de Compostela Spain

Hospital Interzonal General de Agudos Eva Perón San Martín Buenos Aires Argentina

Hospital Universitario la Paz Madrid Spain

Hospital Universitario Ramon y Cajal IRYCIS Madrid Spain

Human Genetics Center School of Public Health University of Texas Health Science Center at Houston Houston TX USA

Human Genetics School of Life Sciences Life Sciences Building University Park University of Nottingham Nottingham UK

Human Genetics School of Life Sciences University of Nottingham Nottingham UK

Human Genome Sequencing Center Baylor College of Medicine Houston TX USA

Icelandic Heart Association Faculty of Medicine University of Iceland Reykjavik Iceland

Icelandic Heart Association Kopovagur Iceland

INSERM Bordeaux Population Health Research Center UMR 1219 ISPED CIC 1401 EC Université de Bordeaux Bordeaux France

Institut de Biomedicina de València CSIC CIBERNED València Spain

Institut de Recerca Biomedica de Lleida Lleida Spain

Institute Born Bunge University of Antwerp Antwerp Belgium

Institute for Regenerative Medicine University of Zürich Schlieren Switzerland

Institute for Stroke and Dementia Research Klinikum der Universität München Ludwig Maximilians Universität Munich Germany

Institute for Urban Public Health University Hospital of University Duisburg Essen Essen Germany

Institute of Biomedicine University of Eastern Finland Kuopio Finland

Institute of Clinical Medicine Internal Medicine University of Eastern Finland Kuopio Finland

Institute of Clinical Medicine Neurology University of Eastern Kuopio Finland

Institute of Clinical Medicine The University of Bergen Bergen Norway

Institute of Clinical Medicine University of Oslo Oslo Norway

Institute of Cognitive Neurology and Dementia Research Otto Von Guericke University Magdeburg Germany

Institute of Gerontology and Geriatrics Department of Medicine and Surgery University of Perugia Perugia Italy

Institute of Human Genetics University of Bonn School of Medicine and University Hospital Bonn Bonn Germany

Institute of Medical Biometry Informatics and Epidemiology University Hospital of Bonn Bonn Germany

Institute of Neurology Catholic University of the Sacred Heart Rome Italy

Institute of Psychiatry and Psychotherapy Charité Universitätsmedizin Berlin Freie Universität Berlin Humboldt Universität Zu Berlin and Berlin Institute of Health Berlin Germany

Institute of Psychiatry Psychology and Neuroscience London UK

Institute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio Finland

Institute of Public Health University of Cambridge Cambridge UK

Institute of Social Medicine Occupational Health and Public Health University of Leipzig Leipzig Germany

Instituto de Investigacion Sanitaria 'Hospital la Paz' Madrid Spain

International Clinical Research Center St Anne's University Hospital Brno Brno Czechia

Intramural Research Program National Institute on Aging National Institutes of Health Bethesda MD USA

IRCCS Fondazione Don Carlo Gnocchi Florence Italy

Klinikum rechts der Isar Department of Psychiatry and Psychotherapy Technical University of Munich School of Medicine Munich Germany

Laboratorio de Bioquímica Molecular Facultad de Medicina Instituto de Investigaciones Médicas A Lanari UBA C A B A Buenos Aires Argentina

Laboratorio de Genética Hospital Universitario Central de Asturias Oviedo Spain

Laboratory for Advanced Hematological Diagnostics Department of Hematology and Stem Cell Transplant Vito Fazzi Hospital Lecce Italy

Laboratory for Cognitive Neurology Department of Neurosciences University of Leuven Leuven Belgium

Laboratory of Brain Aging and Neurodegeneration FIL CONICET Buenos Aires Argentina

Laboratory of Cognitive Neuroscience School of Psychology Aristotle University of Thessaloniki Thessaloniki Greece

Laboratory of Epidemiology Demography and Biometry National Institute of Aging The National Institutes of Health Bethesda MD USA

Laboratory of Neurogenetics Department of Internal Medicine Texas Tech University Health Science Center Lubbock TX USA

Laboratory of Neurogenetics Institute Born Bunge Antwerp Belgium

Laboratory of Neuropsychiatry Department of Clinical and Behavioral Neurology IRCCS Santa Lucia Foundation Rome Italy

LACDR Leiden the Netherlands

LVR Hospital Essen Department of Psychiatry and Psychotherapy Medical Faculty University of Duisburg Essen Essen Germany

MAC Memory Clinic IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy

Medical Science Department iBiMED Aveiro Portugal

Medicine Biomedical Genetics Boston University School of Medicine Boston MA USA

Memory Clinic Department of Neurology Charles University 2nd Faculty of Medicine and Motol University Hospital Praha Czechia

Memory Disorders Unit Department of Neurology Hospital Universitari Mutua de Terrassa Terrassa Spain

Memory Impairment and Neurodegenerative Dementia Center University of Mississippi Medical Center Jackson MS USA

Molecular Markers Laboratory IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli Brescia Italy

MRC Centre for Neuropsychiatric Genetics and Genomics Division of Psychological Medicine and Clinical Neuroscience School of Medicine Cardiff University Cardiff UK

MRC Prion Unit at UCL UCL Institute of Prion Diseases London UK

Munich Cluster for Systems Neurology Munich Germany

Nash Family Department of Neuroscience and Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York NY USA

Neurodegenerative Brain Diseases Group VIB Center for Molecular Neurology VIB Antwerp Belgium

Neuroepidemiology and Ageing Research Unit School of Public Health Imperial College London London UK

Neurological Tissue Bank of the Biobanc Hospital Clinic IDIBAPS Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain

Neurology Department Hospital Clínic IDIBAPS Universitat de Barcelona Barcelona Spain

Neurology Department University Hospitals Leuven Leuven Belgium

Neurology Service Marqués de Valdecilla University Hospital Santander Spain

Neurology Unit San Gerardo Hospital Monza Italy

Neuropsychiatry Epidemiological and Clinical Research PSNREC Université de Montpellier INSERM U1061 Montpellier France

Neuroscience Center Zurich University of Zurich and ETH Zurich Zurich Switzerland

Neurosciences Area Instituto Biodonostia San Sebastian Spain

NORMENT Centre University of Oslo Oslo Norway

Nuffield Department of Population Health Oxford University Oxford UK

Old Age Psychiatry Department of Psychiatry Lausanne University Hospital Lausanne Switzerland

Pole Santé Publique CHU de Bordeaux Bordeaux France

Public Health Promotion Unit Finnish Institute for Health and Welfare Helsinki Finland

Radboudumc Alzheimer Center Department of Geriatrics Radboud University Medical Center Nijmegen the Netherlands

Reference Center for Biological Markers of Dementia Institute Born Bunge University of Antwerp Antwerp Belgium

Research and Development UnitStockholms Sjukhem Stockholm Sweden

Research Center and Memory Clinic Fundació ACE Institut Català de Neurociències Aplicades Universitat Internacional de Catalunya Barcelona Spain

Resources and Research Memory Center of Distalz LicendUniversity of Lille INSERM CHU Lille UMR1172 Lille France

Reta Lila Weston Research Laboratories Department of Molecular Neuroscience UCL Institute of Neurology London UK

Ronald M Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai New York NY USA

Sanders Brown Center on Aging Department of Biostatistics University of Kentucky Lexington KY USA

School of Health Sciences Bangor University Bangor UK

School of Medicine and Surgery University of Milano Bicocca Milano Italy

School of Medicine University of Thessaly Larissa Greece

School of Public Health University of Texas Health Science Center at Houston Houston TX USA

Section Genomics of Neurodegenerative Diseases and Aging Department of Human Genetics Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands

Servei de Neurologia Hospital Universitari i Politècnic La Fe Valencia Spain

Servicio de Neurología Hospital Universitario Central de Asturias Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias Oviedo Spain

Stockholm Gerontology Research Center Stockholm Sweden

Taub Institute Columbia University New York NY USA

Taub Institute on Alzheimer's Disease and the Aging Brain Department of Neurology Columbia University New York NY USA

The John P Hussman Institute for Human Genomics University of Miami Miami FL USA

Translational Health Sciences Bristol Medical School University of Bristol Bristol UK

UFIEC Instituto de Salud Carlos 3 Madrid Spain

Unidad Clínica de Enfermedades Infecciosas y Microbiología Hospital Universitario de Valme Sevilla Spain

Unidad de Demencias Hospital Clínico Universitario Virgen de la Arrixaca Murcia Spain

Unidad de Demencias Servicio de Neurología y Neurofisiología Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla Seville Spain

Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología Instituto de Biomedicina de Sevilla Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla Seville Spain

Unit for Hereditary Dementias Karolinska University Hospital Solna Stockholm Sweden

Unit of Clinical Pharmacology University Hospital of Cagliari Cagliari Italy

Unit of Neurology University of Parma and AOU Parma Italy

Unitat Mixta de de Neurología y Genética Institut d'Investigació Sanitària La Fe València Spain

Unitat Trastorns Cognitius Hospital Universitari Santa Maria de Lleida Lleida Spain

Université de Lille INSERM CHU Lille Institut Pasteur Lille U1167 RID AGE Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement Lille France

University of Bari A Moro Bary Italy

University of Milan Milan Italy

US 41 UMS 2014 PLBS bilille Université de Lille CNRS INSERM CHU Lille Institut Pasteur de Lille Lille France

Vanderbilt Brain Institute Vanderbilt University Nashville TN USA

Wales Centre for Ageing and Dementia Research Swansea University Wales New Zealand

Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland

Citace poskytuje Crossref.org

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$a 10.1038/s41588-022-01024-z $2 doi
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$a Bellenguez, Céline $u Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. celine.bellenguez@pasteur-lille.fr $1 https://orcid.org/0000000212407874
245    10
$a New insights into the genetic etiology of Alzheimer's disease and related dementias / $c C. Bellenguez, F. Küçükali, IE. Jansen, L. Kleineidam, S. Moreno-Grau, N. Amin, AC. Naj, R. Campos-Martin, B. Grenier-Boley, V. Andrade, PA. Holmans, A. Boland, V. Damotte, SJ. van der Lee, MR. Costa, T. Kuulasmaa, Q. Yang, I. de Rojas, JC. Bis, A. Yaqub, I. Prokic, J. Chapuis, S. Ahmad, V. Giedraitis, D. Aarsland, P. Garcia-Gonzalez, C. Abdelnour, E. Alarcón-Martín, D. Alcolea, M. Alegret, I. Alvarez, V. Álvarez, NJ. Armstrong, A. Tsolaki, C. Antúnez, I. Appollonio, M. Arcaro, S. Archetti, AA. Pastor, B. Arosio, L. Athanasiu, H. Bailly, N. Banaj, M. Baquero, S. Barral, A. Beiser, AB. Pastor, JE. Below, P. Benchek, L. Benussi, C. Berr, C. Besse, V. Bessi, G. Binetti, A. Bizarro, R. Blesa, M. Boada, E. Boerwinkle, B. Borroni, S. Boschi, P. Bossù, G. Bråthen, J. Bressler, C. Bresner, H. Brodaty, KJ. Brookes, LI. Brusco, D. Buiza-Rueda, K. Bûrger, V. Burholt, WS. Bush, M. Calero, LB. Cantwell, G. Chene, J. Chung, ML. Cuccaro, Á. Carracedo, R. Cecchetti, L. Cervera-Carles, C. Charbonnier, HH. Chen, C. Chillotti, S. Ciccone, JAHR. Claassen, C. Clark, E. Conti, A. Corma-Gómez, E. Costantini, C. Custodero, D. Daian, MC. Dalmasso, A. Daniele, E. Dardiotis, JF. Dartigues, PP. de Deyn, K. de Paiva Lopes, LD. de Witte, S. Debette, J. Deckert, T. Del Ser, N. Denning, A. DeStefano, M. Dichgans, J. Diehl-Schmid, M. Diez-Fairen, PD. Rossi, S. Djurovic, E. Duron, E. Düzel, C. Dufouil, G. Eiriksdottir, S. Engelborghs, V. Escott-Price, A. Espinosa, M. Ewers, KM. Faber, T. Fabrizio, SF. Nielsen, DW. Fardo, L. Farotti, C. Fenoglio, M. Fernández-Fuertes, R. Ferrari, CB. Ferreira, E. Ferri, B. Fin, P. Fischer, T. Fladby, K. Fließbach, B. Fongang, M. Fornage, J. Fortea, TM. Foroud, S. Fostinelli, NC. Fox, E. Franco-Macías, MJ. Bullido, A. Frank-García, L. Froelich, B. Fulton-Howard, D. Galimberti, JM. García-Alberca, P. García-González, S. Garcia-Madrona, G. Garcia-Ribas, R. Ghidoni, I. Giegling, G. Giorgio, AM. Goate, O. Goldhardt, D. Gomez-Fonseca, A. González-Pérez, C. Graff, G. Grande, E. Green, T. Grimmer, E. Grünblatt, M. Grunin, V. Gudnason, T. Guetta-Baranes, A. Haapasalo, G. Hadjigeorgiou, JL. Haines, KL. Hamilton-Nelson, H. Hampel, O. Hanon, J. Hardy, AM. Hartmann, L. Hausner, J. Harwood, S. Heilmann-Heimbach, S. Helisalmi, MT. Heneka, I. Hernández, MJ. Herrmann, P. Hoffmann, C. Holmes, H. Holstege, RH. Vilas, M. Hulsman, J. Humphrey, GJ. Biessels, X. Jian, C. Johansson, GR. Jun, Y. Kastumata, J. Kauwe, PG. Kehoe, L. Kilander, AK. Ståhlbom, M. Kivipelto, A. Koivisto, J. Kornhuber, MH. Kosmidis, WA. Kukull, PP. Kuksa, BW. Kunkle, AB. Kuzma, C. Lage, EJ. Laukka, L. Launer, A. Lauria, CY. Lee, J. Lehtisalo, O. Lerch, A. Lleó, W. Longstreth, O. Lopez, AL. de Munain, S. Love, M. Löwemark, L. Luckcuck, KL. Lunetta, Y. Ma, J. Macías, CA. MacLeod, W. Maier, F. Mangialasche, M. Spallazzi, M. Marquié, R. Marshall, ER. Martin, AM. Montes, CM. Rodríguez, C. Masullo, R. Mayeux, S. Mead, P. Mecocci, M. Medina, A. Meggy, S. Mehrabian, S. Mendoza, M. Menéndez-González, P. Mir, S. Moebus, M. Mol, L. Molina-Porcel, L. Montrreal, L. Morelli, F. Moreno, K. Morgan, T. Mosley, MM. Nöthen, C. Muchnik, S. Mukherjee, B. Nacmias, T. Ngandu, G. Nicolas, BG. Nordestgaard, R. Olaso, A. Orellana, M. Orsini, G. Ortega, A. Padovani, C. Paolo, G. Papenberg, L. Parnetti, F. Pasquier, P. Pastor, G. Peloso, A. Pérez-Cordón, J. Pérez-Tur, P. Pericard, O. Peters, YAL. Pijnenburg, JA. Pineda, G. Piñol-Ripoll, C. Pisanu, T. Polak, J. Popp, D. Posthuma, J. Priller, R. Puerta, O. Quenez, I. Quintela, JQ. Thomassen, A. Rábano, I. Rainero, F. Rajabli, I. Ramakers, LM. Real, MJT. Reinders, C. Reitz, D. Reyes-Dumeyer, P. Ridge, S. Riedel-Heller, P. Riederer, N. Roberto, E. Rodriguez-Rodriguez, A. Rongve, IR. Allende, M. Rosende-Roca, JL. Royo, E. Rubino, D. Rujescu, ME. Sáez, P. Sakka, I. Saltvedt, Á. Sanabria, MB. Sánchez-Arjona, F. Sanchez-Garcia, PS. Juan, R. Sánchez-Valle, SB. Sando, C. Sarnowski, CL. Satizabal, M. Scamosci, N. Scarmeas, E. Scarpini, P. Scheltens, N. Scherbaum, M. Scherer, M. Schmid, A. Schneider, JM. Schott, G. Selbæk, D. Seripa, M. Serrano, J. Sha, AA. Shadrin, O. Skrobot, S. Slifer, GJL. Snijders, H. Soininen, V. Solfrizzi, A. Solomon, Y. Song, S. Sorbi, O. Sotolongo-Grau, G. Spalletta, A. Spottke, A. Squassina, E. Stordal, JP. Tartan, L. Tárraga, N. Tesí, A. Thalamuthu, T. Thomas, G. Tosto, L. Traykov, L. Tremolizzo, A. Tybjærg-Hansen, A. Uitterlinden, A. Ullgren, I. Ulstein, S. Valero, O. Valladares, CV. Broeckhoven, J. Vance, BN. Vardarajan, A. van der Lugt, JV. Dongen, J. van Rooij, J. van Swieten, R. Vandenberghe, F. Verhey, JS. Vidal, J. Vogelgsang, M. Vyhnalek, M. Wagner, D. Wallon, LS. Wang, R. Wang, L. Weinhold, J. Wiltfang, G. Windle, B. Woods, M. Yannakoulia, H. Zare, Y. Zhao, X. Zhang, C. Zhu, M. Zulaica, EADB, GR@ACE, DEGESCO, EADI, GERAD, Demgene, FinnGen, ADGC, CHARGE, LA. Farrer, BM. Psaty, M. Ghanbari, T. Raj, P. Sachdev, K. Mather, F. Jessen, MA. Ikram, A. de Mendonça, J. Hort, M. Tsolaki, MA. Pericak-Vance, P. Amouyel, J. Williams, R. Frikke-Schmidt, J. Clarimon, JF. Deleuze, G. Rossi, S. Seshadri, OA. Andreassen, M. Ingelsson, M. Hiltunen, K. Sleegers, GD. Schellenberg, CM. van Duijn, R. Sims, WM. van der Flier, A. Ruiz, A. Ramirez, JC. Lambert
520    9_
$a Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.
650    12
$a Alzheimerova nemoc $x genetika $x patologie $7 D000544
650    12
$a kognitivní dysfunkce $x psychologie $7 D060825
650    _2
$a celogenomová asociační studie $7 D055106
650    _2
$a lidé $7 D006801
650    _2
$a proteiny tau $x genetika $7 D016875
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a Research Support, U.S. Gov't, Non-P.H.S. $7 D013486
655    _2
$a Research Support, N.I.H., Extramural $7 D052061
700    1_
$a Küçükali, Fahri $u Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium $u Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium $u Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium $1 https://orcid.org/0000000238359639
700    1_
$a Jansen, Iris E $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $u Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands
700    1_
$a Kleineidam, Luca $u Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany $u Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany $u German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany
700    1_
$a Moreno-Grau, Sonia $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Amin, Najaf $u Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands $u Nuffield Department of Population Health, Oxford University, Oxford, UK $1 https://orcid.org/0000000289441771
700    1_
$a Naj, Adam C $u Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA $u Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
700    1_
$a Campos-Martin, Rafael $u Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany
700    1_
$a Grenier-Boley, Benjamin $u Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France
700    1_
$a Andrade, Victor $u Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany $u Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany
700    1_
$a Holmans, Peter A $u MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK $1 https://orcid.org/0000000308709412
700    1_
$a Boland, Anne $u CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France
700    1_
$a Damotte, Vincent $u Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France
700    1_
$a van der Lee, Sven J $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $u Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $1 https://orcid.org/0000000316068643
700    1_
$a Costa, Marcos R $u Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France $u Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil $1 https://orcid.org/0000000249282163
700    1_
$a Kuulasmaa, Teemu $u Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland $1 https://orcid.org/0000000217957314
700    1_
$a Yang, Qiong $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA $u Framingham Heart Study, Framingham, MA, USA $1 https://orcid.org/0000000236581375
700    1_
$a de Rojas, Itziar $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $1 https://orcid.org/000000022148381X
700    1_
$a Bis, Joshua C $u Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA $1 https://orcid.org/0000000234091110
700    1_
$a Yaqub, Amber $u Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands $1 https://orcid.org/0000000235798054
700    1_
$a Prokic, Ivana $u Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands $1 https://orcid.org/0000000203701473
700    1_
$a Chapuis, Julien $u Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France $1 https://orcid.org/0000000258022857
700    1_
$a Ahmad, Shahzad $u Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands $u LACDR, Leiden, the Netherlands $1 https://orcid.org/0000000286583790
700    1_
$a Giedraitis, Vilmantas $u Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden $1 https://orcid.org/0000000334232021
700    1_
$a Aarsland, Dag $u Centre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway $u Institute of Psychiatry, Psychology & Neuroscience, London, UK
700    1_
$a Garcia-Gonzalez, Pablo $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $1 https://orcid.org/0000000301255403
700    1_
$a Abdelnour, Carla $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Alarcón-Martín, Emilio $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u Department of Surgery, Biochemistry and Molecular Biology, School of Medicine, University of Málaga, Málaga, Spain
700    1_
$a Alcolea, Daniel $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain $1 https://orcid.org/0000000238193245
700    1_
$a Alegret, Montserrat $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Alvarez, Ignacio $u Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain $u Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain $1 https://orcid.org/0000000285373935
700    1_
$a Álvarez, Victoria $u Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain $u Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain
700    1_
$a Armstrong, Nicola J $u Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
700    1_
$a Tsolaki, Anthoula $u First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece $u Alzheimer Hellas, Thessaloniki, Greece $1 https://orcid.org/0000000255637776
700    1_
$a Antúnez, Carmen $u Unidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain
700    1_
$a Appollonio, Ildebrando $u School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy $u Neurology Unit, San Gerardo Hospital, Monza, Italy
700    1_
$a Arcaro, Marina $u Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy
700    1_
$a Archetti, Silvana $u Department of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital, Brescia, Italy
700    1_
$a Pastor, Alfonso Arias $u Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain $u Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain
700    1_
$a Arosio, Beatrice $u Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy $u Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
700    1_
$a Athanasiu, Lavinia $u NORMENT Centre, University of Oslo, Oslo, Norway
700    1_
$a Bailly, Henri $u EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France
700    1_
$a Banaj, Nerisa $u Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
700    1_
$a Baquero, Miquel $u Servei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain $1 https://orcid.org/0000000268611831
700    1_
$a Barral, Sandra $u Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA $u Unit of Neurology, University of Parma and AOU, Parma, Italy $u Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria
700    1_
$a Beiser, Alexa $u Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland $u Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA
700    1_
$a Pastor, Ana Belén $u CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain $1 https://orcid.org/0000000196374688
700    1_
$a Below, Jennifer E $u Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA
700    1_
$a Benchek, Penelope $u Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA $u Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA
700    1_
$a Benussi, Luisa $u Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
700    1_
$a Berr, Claudine $u Neuropsychiatry: Epidemiological and Clinical Research, PSNREC, Université de Montpellier, INSERM U1061, Montpellier, France $1 https://orcid.org/0000000152547655
700    1_
$a Besse, Céline $u CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France
700    1_
$a Bessi, Valentina $u Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy $u Azienda Ospedaliero-Universitaria Careggi, Florence, Italy $1 https://orcid.org/0000000261763584
700    1_
$a Binetti, Giuliano $u Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy $u MAC - Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
700    1_
$a Bizarro, Alessandra $u Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy
700    1_
$a Blesa, Rafael $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
700    1_
$a Boada, Mercè $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $1 https://orcid.org/0000000326173009
700    1_
$a Boerwinkle, Eric $u Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA $u Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA
700    1_
$a Borroni, Barbara $u Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
700    1_
$a Boschi, Silvia $u Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy
700    1_
$a Bossù, Paola $u Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy $1 https://orcid.org/0000000214320078
700    1_
$a Bråthen, Geir $u Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway $u Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway $1 https://orcid.org/0000000332247983
700    1_
$a Bressler, Jan $u Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA $u School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA $1 https://orcid.org/0000000165784772
700    1_
$a Bresner, Catherine $u MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK $1 https://orcid.org/0000000326739762
700    1_
$a Brodaty, Henry $u Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia $u Dementia Centre for Research Collaboration, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia $1 https://orcid.org/0000000194876617
700    1_
$a Brookes, Keeley J $u Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK $1 https://orcid.org/0000000324272513
700    1_
$a Brusco, Luis Ignacio $u Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina $u Departamento Ciencias Fisiológicas UAII, Facultad de Medicina, UBA, C.A.B.A., Buenos Aires, Argentina $u Hospital Interzonal General de Agudos Eva Perón, San Martín, Buenos Aires, Argentina
700    1_
$a Buiza-Rueda, Dolores $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Department of Neurology, Erasmus MC, Rotterdam, the Netherlands
700    1_
$a Bûrger, Katharina $u Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany $u German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany
700    1_
$a Burholt, Vanessa $u Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand $u Wales Centre for Ageing & Dementia Research, Swansea University, Wales, New Zealand $1 https://orcid.org/000000026789127X
700    1_
$a Bush, William S $u Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA $1 https://orcid.org/0000000297296519
700    1_
$a Calero, Miguel $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain $u UFIEC, Instituto de Salud Carlos III, Madrid, Spain $1 https://orcid.org/0000000153663324
700    1_
$a Cantwell, Laura B $u Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
700    1_
$a Chene, Geneviève $u INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France $u Pole Santé Publique, CHU de Bordeaux, Bordeaux, France
700    1_
$a Chung, Jaeyoon $u Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA $1 https://orcid.org/0000000264319454
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$a Cuccaro, Michael L $u Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA
700    1_
$a Carracedo, Ángel $u Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain $u Fundación Pública Galega de Medicina Xenómica- CIBERER-IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
700    1_
$a Cecchetti, Roberta $u Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy
700    1_
$a Cervera-Carles, Laura $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain $1 https://orcid.org/000000032286200X
700    1_
$a Charbonnier, Camille $u Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France
700    1_
$a Chen, Hung-Hsin $u Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA
700    1_
$a Chillotti, Caterina $u Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy
700    1_
$a Ciccone, Simona $u Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
700    1_
$a Claassen, Jurgen A H R $u Radboudumc Alzheimer Center, Department of Geriatrics, Radboud University Medical Center, Nijmegen, the Netherlands
700    1_
$a Clark, Christopher $u Institute for Regenerative Medicine, University of Zürich, Schlieren, Switzerland
700    1_
$a Conti, Elisa $u School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy
700    1_
$a Corma-Gómez, Anaïs $u Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain
700    1_
$a Costantini, Emanuele $u Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy $1 https://orcid.org/0000000210968221
700    1_
$a Custodero, Carlo $u University of Bari, "A. Moro", Bary, Italy
700    1_
$a Daian, Delphine $u CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France
700    1_
$a Dalmasso, Maria Carolina $u Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany $1 https://orcid.org/0000000249019955
700    1_
$a Daniele, Antonio $u Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
700    1_
$a Dardiotis, Efthimios $u School of Medicine, University of Thessaly, Larissa, Greece
700    1_
$a Dartigues, Jean-François $u Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France
700    1_
$a de Deyn, Peter Paul $u Department of Neurology, University Medical Center Groningen, Groningen, the Netherlands
700    1_
$a de Paiva Lopes, Katia $u Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA $u Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA $u Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA $u Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA $1 https://orcid.org/0000000202400126
700    1_
$a de Witte, Lot D $u Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA $1 https://orcid.org/0000000272359958
700    1_
$a Debette, Stéphanie $u Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France $1 https://orcid.org/0000000186757968
700    1_
$a Deckert, Jürgen $u Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany
700    1_
$a Del Ser, Teodoro $u CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain $1 https://orcid.org/0000000198067083
700    1_
$a Denning, Nicola $u UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK
700    1_
$a DeStefano, Anita $u Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA $u Department of Neurology, Boston University School of Medicine, Boston, MA, USA
700    1_
$a Dichgans, Martin $u Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany $u Munich Cluster for Systems Neurology (SyNergy), Munich, Germany $1 https://orcid.org/000000020654387X
700    1_
$a Diehl-Schmid, Janine $u Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany $1 https://orcid.org/0000000277451382
700    1_
$a Diez-Fairen, Mónica $u Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain $u Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain $1 https://orcid.org/0000000318820309
700    1_
$a Rossi, Paolo Dionigi $u Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
700    1_
$a Djurovic, Srdjan $u NORMENT Centre, University of Oslo, Oslo, Norway $1 https://orcid.org/0000000281408061
700    1_
$a Duron, Emmanuelle $u EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France
700    1_
$a Düzel, Emrah $u Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany $u German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
700    1_
$a Dufouil, Carole $u INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France $u Pole Santé Publique, CHU de Bordeaux, Bordeaux, France $1 https://orcid.org/0000000324424476
700    1_
$a Eiriksdottir, Gudny $u Icelandic Heart Association, Kopovagur, Iceland
700    1_
$a Engelborghs, Sebastiaan $u Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium $u Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium $u Institute Born-Bunge, University of Antwerp, Antwerp, Belgium $u Department of Neurology, UZ Brussel, Brussels, Belgium
700    1_
$a Escott-Price, Valentina $u Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA $u UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK $1 https://orcid.org/0000000317845483
700    1_
$a Espinosa, Ana $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Ewers, Michael $u Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany $u German Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany $1 https://orcid.org/0000000152311714
700    1_
$a Faber, Kelley M $u Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA
700    1_
$a Fabrizio, Tagliavini $u Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy $1 https://orcid.org/0000000310397315
700    1_
$a Nielsen, Sune Fallgaard $u Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark
700    1_
$a Fardo, David W $u Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA
700    1_
$a Farotti, Lucia $u Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy
700    1_
$a Fenoglio, Chiara $u University of Milan, Milan, Italy
700    1_
$a Fernández-Fuertes, Marta $u Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain
700    1_
$a Ferrari, Raffaele $u Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA $u Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
700    1_
$a Ferreira, Catarina B $u Faculty of Medicine, University of Lisbon, Lisbon, Portugal
700    1_
$a Ferri, Evelyn $u Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
700    1_
$a Fin, Bertrand $u CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France
700    1_
$a Fischer, Peter $u Department of Psychiatry, Social Medicine Center East- Donauspital, Vienna, Austria
700    1_
$a Fladby, Tormod $u Institute of Clinical Medicine, University of Oslo, Oslo, Norway $1 https://orcid.org/0000000299849797
700    1_
$a Fließbach, Klaus $u Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany $u German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany
700    1_
$a Fongang, Bernard $u Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA
700    1_
$a Fornage, Myriam $u Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway $u School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA $1 https://orcid.org/0000000306778158
700    1_
$a Fortea, Juan $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
700    1_
$a Foroud, Tatiana M $u Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA
700    1_
$a Fostinelli, Silvia $u Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
700    1_
$a Fox, Nick C $u Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK $1 https://orcid.org/000000026660657X
700    1_
$a Franco-Macías, Emlio $u Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain
700    1_
$a Bullido, María J $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain $u Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain $1 https://orcid.org/0000000264771117
700    1_
$a Frank-García, Ana $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain $u Hospital Universitario la Paz, Madrid, Spain
700    1_
$a Froelich, Lutz $u Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany $1 https://orcid.org/0000000314940813
700    1_
$a Fulton-Howard, Brian $u Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA
700    1_
$a Galimberti, Daniela $u Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy $u University of Milan, Milan, Italy $1 https://orcid.org/0000000292845953
700    1_
$a García-Alberca, Jose Maria $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain $1 https://orcid.org/0000000329516644
700    1_
$a García-González, Pablo $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
700    1_
$a Garcia-Madrona, Sebastian $u Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain
700    1_
$a Garcia-Ribas, Guillermo $u Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain
700    1_
$a Ghidoni, Roberta $u Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
700    1_
$a Giegling, Ina $u Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
700    1_
$a Giorgio, Giaccone $u Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy
700    1_
$a Goate, Alison M $u Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA $1 https://orcid.org/0000000205762472
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$a Goldhardt, Oliver $u Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany
700    1_
$a Gomez-Fonseca, Duber $u Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
700    1_
$a González-Pérez, Antonio $u CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain $1 https://orcid.org/0000000197715982
700    1_
$a Graff, Caroline $u Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden $u Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden
700    1_
$a Grande, Giulia $u Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
700    1_
$a Green, Emma $u Institute of Public Health, University of Cambridge, Cambridge, UK $1 https://orcid.org/0000000286875590
700    1_
$a Grimmer, Timo $u Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany
700    1_
$a Grünblatt, Edna $u Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland $u Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland $u Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland $1 https://orcid.org/0000000185057265
700    1_
$a Grunin, Michelle $u Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA
700    1_
$a Gudnason, Vilmundur $u Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, Iceland $1 https://orcid.org/0000000156960084
700    1_
$a Guetta-Baranes, Tamar $u Human Genetics, School of Life Sciences, Life Sciences Building, University Park, University of Nottingham, Nottingham, UK
700    1_
$a Haapasalo, Annakaisa $u AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland $1 https://orcid.org/0000000309592957
700    1_
$a Hadjigeorgiou, Georgios $u Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus
700    1_
$a Haines, Jonathan L $u Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA
700    1_
$a Hamilton-Nelson, Kara L $u The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA
700    1_
$a Hampel, Harald $u GRC 21, Alzheimer Precision Medicine Initiative (APMI), Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France
700    1_
$a Hanon, Olivier $u EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France
700    1_
$a Hardy, John $u Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK
700    1_
$a Hartmann, Annette M $u Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
700    1_
$a Hausner, Lucrezia $u Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany
700    1_
$a Harwood, Janet $u MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK $1 https://orcid.org/0000000232250069
700    1_
$a Heilmann-Heimbach, Stefanie $u Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany $1 https://orcid.org/000000031057465X
700    1_
$a Helisalmi, Seppo $u Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland $u Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland
700    1_
$a Heneka, Michael T $u Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany $u German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany
700    1_
$a Hernández, Isabel $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Herrmann, Martin J $u Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany $1 https://orcid.org/0000000199702122
700    1_
$a Hoffmann, Per $u Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
700    1_
$a Holmes, Clive $u Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, UK
700    1_
$a Holstege, Henne $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $u Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $1 https://orcid.org/0000000276883087
700    1_
$a Vilas, Raquel Huerto $u Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain $u Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain
700    1_
$a Hulsman, Marc $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $u Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
700    1_
$a Humphrey, Jack $u Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA $u Department of Genetics and Genomic Sciences & Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA $u Estelle and Daniel Maggin Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA $u Nash Family Department of Neuroscience & Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
700    1_
$a Biessels, Geert Jan $u Department of Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands $1 https://orcid.org/0000000168622496
700    1_
$a Jian, Xueqiu $u Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA $1 https://orcid.org/0000000203136494
700    1_
$a Johansson, Charlotte $u Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden $1 https://orcid.org/0000000253511950
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$a Jun, Gyungah R $u Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA $1 https://orcid.org/0000000232308697
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$a Kastumata, Yuriko $u Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA $1 https://orcid.org/0000000201888094
700    1_
$a Kauwe, John $u Department of Biology, Brigham Young University, Provo, UT, USA
700    1_
$a Kehoe, Patrick G $u Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK $1 https://orcid.org/0000000275421139
700    1_
$a Kilander, Lena $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
700    1_
$a Ståhlbom, Anne Kinhult $u Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Kivipelto, Miia $u Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden $u Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland $u Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, UK $u Research & Development, UnitStockholms Sjukhem, Stockholm, Sweden
700    1_
$a Koivisto, Anne $u Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland $u Department of Neurology, Kuopio University Hospital, Kuopio, Finland $u Department of Neurosciences, University of Helsinki and Department of Geriatrics, Helsinki University Hospital, Helsinki, Finland
700    1_
$a Kornhuber, Johannes $u Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany $1 https://orcid.org/0000000280963987
700    1_
$a Kosmidis, Mary H $u Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece $1 https://orcid.org/0000000187901220
700    1_
$a Kukull, Walter A $u Department of Epidemiology, University of Washington, Seattle, WA, USA
700    1_
$a Kuksa, Pavel P $u Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
700    1_
$a Kunkle, Brian W $u Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus
700    1_
$a Kuzma, Amanda B $u Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
700    1_
$a Lage, Carmen $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain $1 https://orcid.org/000000031703121X
700    1_
$a Laukka, Erika J $u Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden $u Stockholm Gerontology Research Center, Stockholm, Sweden
700    1_
$a Launer, Lenore $u Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, MD, USA $u Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA $1 https://orcid.org/0000000232387612
700    1_
$a Lauria, Alessandra $u Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy
700    1_
$a Lee, Chien-Yueh $u Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA $1 https://orcid.org/000000024304974X
700    1_
$a Lehtisalo, Jenni $u Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland $u Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
700    1_
$a Lerch, Ondrej $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia $u International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czechia
700    1_
$a Lleó, Alberto $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain $1 https://orcid.org/0000000225685478
700    1_
$a Longstreth, William $u Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA
700    1_
$a Lopez, Oscar $u Framingham Heart Study, Framingham, MA, USA $1 https://orcid.org/0000000285468256
700    1_
$a de Munain, Adolfo Lopez $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Department of Neurology, Hospital Universitario Donostia, OSAKIDETZA-Servicio Vasco de Salud, San Sebastian, Spain $1 https://orcid.org/0000000295094032
700    1_
$a Love, Seth $u Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
700    1_
$a Löwemark, Malin $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
700    1_
$a Luckcuck, Lauren $u MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK
700    1_
$a Lunetta, Kathryn L $u Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland $1 https://orcid.org/000000029268810X
700    1_
$a Ma, Yiyi $u Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $u Department of Neurology, Columbia University, New York, NY, USA $1 https://orcid.org/0000000236098877
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$a Macías, Juan $u Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain
700    1_
$a MacLeod, Catherine A $u School of Health Sciences, Bangor University, Bangor, UK $1 https://orcid.org/0000000293147380
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$a Maier, Wolfgang $u Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany $u German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany
700    1_
$a Mangialasche, Francesca $u Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden
700    1_
$a Spallazzi, Marco $u Unit of Neurology, University of Parma and AOU, Parma, Italy
700    1_
$a Marquié, Marta $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $1 https://orcid.org/0000000206600950
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$a Marshall, Rachel $u MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK
700    1_
$a Martin, Eden R $u The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA
700    1_
$a Montes, Angel Martín $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain $u Hospital Universitario la Paz, Madrid, Spain $1 https://orcid.org/000000021694786X
700    1_
$a Rodríguez, Carmen Martínez $u Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain
700    1_
$a Masullo, Carlo $u Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy
700    1_
$a Mayeux, Richard $u Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA $u Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA
700    1_
$a Mead, Simon $u MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK $1 https://orcid.org/0000000243261468
700    1_
$a Mecocci, Patrizia $u Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy
700    1_
$a Medina, Miguel $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain $1 https://orcid.org/0000000270165340
700    1_
$a Meggy, Alun $u UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK
700    1_
$a Mehrabian, Shima $u Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria
700    1_
$a Mendoza, Silvia $u Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain
700    1_
$a Menéndez-González, Manuel $u Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain $1 https://orcid.org/0000000252180774
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$a Mir, Pablo $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain
700    1_
$a Moebus, Susanne $u Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany
700    1_
$a Mol, Merel $u Department of Neurology, Erasmus MC, Rotterdam, the Netherlands $1 https://orcid.org/0000000325332530
700    1_
$a Molina-Porcel, Laura $u Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain $u Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain
700    1_
$a Montrreal, Laura $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
700    1_
$a Morelli, Laura $u Laboratory of Brain Aging and Neurodegeneration, FIL-CONICET, Buenos Aires, Argentina
700    1_
$a Moreno, Fermin $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Department of Neurology, Hospital Universitario Donostia, OSAKIDETZA-Servicio Vasco de Salud, San Sebastian, Spain
700    1_
$a Morgan, Kevin $u Human Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK $1 https://orcid.org/0000000282172396
700    1_
$a Mosley, Thomas $u Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA
700    1_
$a Nöthen, Markus M $u Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany $1 https://orcid.org/0000000287702464
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$a Muchnik, Carolina $u Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina $u Laboratorio de Bioquímica Molecular, Facultad de Medicina, Instituto de Investigaciones Médicas A. Lanari, UBA, C.A.B.A, Buenos Aires, Argentina $1 https://orcid.org/0000000215423706
700    1_
$a Mukherjee, Shubhabrata $u Department of Medicine, University of Washington, Seattle, WA, USA
700    1_
$a Nacmias, Benedetta $u Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy $u IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy $1 https://orcid.org/0000000193389040
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$a Ngandu, Tiia $u Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
700    1_
$a Nicolas, Gael $u Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France $1 https://orcid.org/0000000193917800
700    1_
$a Nordestgaard, Børge G $u Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark $u Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark $1 https://orcid.org/0000000219547220
700    1_
$a Olaso, Robert $u CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France
700    1_
$a Orellana, Adelina $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Orsini, Michela $u Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
700    1_
$a Ortega, Gemma $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Padovani, Alessandro $u Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA
700    1_
$a Paolo, Caffarra $u DIMEC, University of Parma, Parma, Italy
700    1_
$a Papenberg, Goran $u Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
700    1_
$a Parnetti, Lucilla $u Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy
700    1_
$a Pasquier, Florence $u Resources and Research Memory Center (MRRC) of Distalz, LicendUniversity of Lille, INSERM, CHU Lille, UMR1172, Lille, France $1 https://orcid.org/0000000198809788
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$a Pastor, Pau $u Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain $u Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Spain $1 https://orcid.org/0000000274938777
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$a Peloso, Gina $u Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland $u Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA $1 https://orcid.org/0000000253558636
700    1_
$a Pérez-Cordón, Alba $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $1 https://orcid.org/0000000260280791
700    1_
$a Pérez-Tur, Jordi $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Institut de Biomedicina de València-CSIC CIBERNED, València, Spain $u Unitat Mixta de de Neurología y Genética, Institut d'Investigació Sanitària La Fe, València, Spain $1 https://orcid.org/0000000291111712
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$a Pericard, Pierre $u US 41-UMS 2014-PLBS, bilille, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Lille, France $1 https://orcid.org/0000000181676448
700    1_
$a Peters, Oliver $u Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany $u German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany
700    1_
$a Pijnenburg, Yolande A L $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
700    1_
$a Pineda, Juan A $u Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain $1 https://orcid.org/0000000237510296
700    1_
$a Piñol-Ripoll, Gerard $u Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain $u Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain
700    1_
$a Pisanu, Claudia $u Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy $1 https://orcid.org/0000000291514319
700    1_
$a Polak, Thomas $u Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany
700    1_
$a Popp, Julius $u CHUV, Old Age Psychiatry, Department of Psychiatry, Lausanne, Switzerland $u Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland $u Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland
700    1_
$a Posthuma, Danielle $u Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands $1 https://orcid.org/0000000175822365
700    1_
$a Priller, Josef $u German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany $u Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité, Charitéplatz 1, Berlin, Germany
700    1_
$a Puerta, Raquel $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $1 https://orcid.org/0000000211915893
700    1_
$a Quenez, Olivier $u Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France $1 https://orcid.org/0000000282738505
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$a Quintela, Inés $u Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain
700    1_
$a Thomassen, Jesper Qvist $u Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark $1 https://orcid.org/0000000334849531
700    1_
$a Rábano, Alberto $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain
700    1_
$a Rainero, Innocenzo $u Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
700    1_
$a Rajabli, Farid $u The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA
700    1_
$a Ramakers, Inez $u Department of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands
700    1_
$a Real, Luis M $u Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain $u Depatamento de Especialidades Quirúrgicas Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain $1 https://orcid.org/0000000349327429
700    1_
$a Reinders, Marcel J T $u Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands $1 https://orcid.org/0000000211481562
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$a Reitz, Christiane $u Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA $u Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands $u Taub Institute, Columbia University, New York, NY, USA $1 https://orcid.org/0000000187577889
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$a Reyes-Dumeyer, Dolly $u Department of Neurology, Columbia University, New York, NY, USA $u Taub Institute, Columbia University, New York, NY, USA
700    1_
$a Ridge, Perry $u Bioinformatics, College of Life Sciences, Brigham Young University, Provo, UT, USA
700    1_
$a Riedel-Heller, Steffi $u Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany $1 https://orcid.org/0000000343216090
700    1_
$a Riederer, Peter $u Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Wuerzburg, Germany
700    1_
$a Roberto, Natalia $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
700    1_
$a Rodriguez-Rodriguez, Eloy $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain $1 https://orcid.org/000000017742677X
700    1_
$a Rongve, Arvid $u Department of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, Norway $u Institute of Clinical Medicine (K1), The University of Bergen, Bergen, Norway $1 https://orcid.org/0000000204764134
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$a Allende, Irene Rosas $u Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain $u Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain
700    1_
$a Rosende-Roca, Maitée $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Royo, Jose Luis $u Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain
700    1_
$a Rubino, Elisa $u Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy
700    1_
$a Rujescu, Dan $u Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
700    1_
$a Sáez, María Eugenia $u CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain $1 https://orcid.org/0000000192992534
700    1_
$a Sakka, Paraskevi $u Athens Association of Alzheimer's Disease and Related Disorders, Athens, Greece
700    1_
$a Saltvedt, Ingvild $u Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway $u Department of Geriatrics, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway $1 https://orcid.org/0000000278979808
700    1_
$a Sanabria, Ángela $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Sánchez-Arjona, María Bernal $u Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain
700    1_
$a Sanchez-Garcia, Florentino $u Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain
700    1_
$a Juan, Pascual Sánchez $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain $1 https://orcid.org/0000000260818037
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$a Sánchez-Valle, Raquel $u Neurology Department-Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain
700    1_
$a Sando, Sigrid B $u Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy $u Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway
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$a Sarnowski, Chloé $u Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA $1 https://orcid.org/0000000260907099
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$a Satizabal, Claudia L $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA $u Department of Neurology, Boston University School of Medicine, Boston, MA, USA $u Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA $1 https://orcid.org/0000000211154430
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$a Scamosci, Michela $u Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy
700    1_
$a Scarmeas, Nikolaos $u Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA $u First Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece
700    1_
$a Scarpini, Elio $u Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy $u University of Milan, Milan, Italy
700    1_
$a Scheltens, Philip $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
700    1_
$a Scherbaum, Norbert $u LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany
700    1_
$a Scherer, Martin $u Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
700    1_
$a Schmid, Matthias $u German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany $u Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany
700    1_
$a Schneider, Anja $u Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany $u German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany
700    1_
$a Schott, Jonathan M $u Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK $1 https://orcid.org/000000032059024X
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$a Selbæk, Geir $u Institute of Clinical Medicine, University of Oslo, Oslo, Norway $u Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway $1 https://orcid.org/0000000165118219
700    1_
$a Seripa, Davide $u Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy
700    1_
$a Serrano, Manuel $u Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Hospital Clínico San Carlos, Madrid, Spain
700    1_
$a Sha, Jin $u Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
700    1_
$a Shadrin, Alexey A $u NORMENT Centre, University of Oslo, Oslo, Norway $1 https://orcid.org/000000027467250X
700    1_
$a Skrobot, Olivia $u Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
700    1_
$a Slifer, Susan $u The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA
700    1_
$a Snijders, Gijsje J L $u Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
700    1_
$a Soininen, Hilkka $u Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland $1 https://orcid.org/0000000227859937
700    1_
$a Solfrizzi, Vincenzo $u University of Bari, "A. Moro", Bary, Italy $1 https://orcid.org/0000000285240315
700    1_
$a Solomon, Alina $u Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland $u Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden
700    1_
$a Song, Yeunjoo $u Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA $1 https://orcid.org/0000000274523731
700    1_
$a Sorbi, Sandro $u Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy $u IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy
700    1_
$a Sotolongo-Grau, Oscar $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $1 https://orcid.org/0000000296790670
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$a Spalletta, Gianfranco $u Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy $1 https://orcid.org/0000000274324249
700    1_
$a Spottke, Annika $u German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany $u Department of Neurology, University of Bonn, Bonn, Germany
700    1_
$a Squassina, Alessio $u Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy $1 https://orcid.org/0000000174157607
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$a Stordal, Eystein $u Department of Psychiatry, Namsos Hospital, Namsos, Norway $1 https://orcid.org/0000000224437923
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$a Tartan, Juan Pablo $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain
700    1_
$a Tárraga, Lluís $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Tesí, Niccolo $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $u Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands
700    1_
$a Thalamuthu, Anbupalam $u Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
700    1_
$a Thomas, Tegos $u First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece $u Alzheimer Hellas, Thessaloniki, Greece
700    1_
$a Tosto, Giuseppe $u Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA $u Department of Neurology, Columbia University, New York, NY, USA $1 https://orcid.org/0000000170758245
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$a Traykov, Latchezar $u Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria
700    1_
$a Tremolizzo, Lucio $u School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy $u Neurology Unit, San Gerardo Hospital, Monza, Italy
700    1_
$a Tybjærg-Hansen, Anne $u Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark $u Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
700    1_
$a Uitterlinden, Andre $u Department of Internal Medicine and Biostatistics, Erasmus MC, Rotterdam, the Netherlands $1 https://orcid.org/0000000272763387
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$a Ullgren, Abbe $u Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden
700    1_
$a Ulstein, Ingun $u Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway
700    1_
$a Valero, Sergi $u Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
700    1_
$a Valladares, Otto $u Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA $1 https://orcid.org/0000000180552187
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$a Broeckhoven, Christine Van $u Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium $u Laboratory of Neurogenetics, Institute Born - Bunge, Antwerp, Belgium $u Neurodegenerative Brain Diseases Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium $1 https://orcid.org/0000000301837665
700    1_
$a Vance, Jeffery $u Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA
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