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The Translesional Spinal Network and Its Reorganization after Spinal Cord Injury

P. Krupa, AM. Siddiqui, PJ. Grahn, R. Islam, BK. Chen, NN. Madigan, AJ. Windebank, IA. Lavrov

. 2022 ; 28 (2) : 163-179. [pub] 20201022

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, přehledy, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.

Perzistentní odkaz   https://www.medvik.cz/link/bmc22019039

Evidence from preclinical and clinical research suggest that neuromodulation technologies can facilitate the sublesional spinal networks, isolated from supraspinal commands after spinal cord injury (SCI), by reestablishing the levels of excitability and enabling descending motor signals via residual connections. Herein, we evaluate available evidence that sublesional and supralesional spinal circuits could form a translesional spinal network after SCI. We further discuss evidence of translesional network reorganization after SCI in the presence of sensory inputs during motor training. In this review, we evaluate potential mechanisms that underlie translesional circuitry reorganization during neuromodulation and rehabilitation in order to enable motor functions after SCI. We discuss the potential of neuromodulation technologies to engage various components that comprise the translesional network, their functional recovery after SCI, and the implications of the concept of translesional network in development of future neuromodulation, rehabilitation, and neuroprosthetics technologies.

Citace poskytuje Crossref.org

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$a Grahn, Peter J $u Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA $u Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA
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$a Islam, Riazul $u Department of Neurology, Mayo Clinic, Rochester, MN, USA
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