• Je něco špatně v tomto záznamu ?

Apelin-13 facilitates lordosis behavior following infusions to the ventromedial hypothalamus or preoptic area in ovariectomized, estrogen-primed rats

M. García-Juárez, A. Luna-Hernández, S. Tapia-Hernández, O. Montes-Narvaez, R. Domínguez-Ordoñez, MB. Tecamachaltzi-Silvarán, JG. Pfaus, O. González-Flores

. 2022 ; 773 (-) : 136518. [pub] 20220209

Jazyk angličtina Země Irsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22019172

In normal hormonal conditions, increased neuronal activity in the ventromedial hypothalamus (VMH) induces lordosis whereas activation of the preoptic area (POA) exerts an opposite effect. In the present work, we explored the effect of bilateral infusion of different doses of the apelin-13 (0.37, 0.75, 1.5, and 15 μg) in both brain areas on the expression of lordosis behavior. Lordosis quotient and lordosis reflex score were performed at 30, 120, and 240 min. Weak lordosis was observed following the 0.37 μg dose of apelin-13 at 30 min in the VMH of EB-primed rats; however, the rest of the doses induced significant lordosis relative to the control group. At 120 min, all doses induced lordosis behavior, while at 240 min, the highest dose of 15 μg did not induce significant differences. Interestingly, only the 0.75 μg infusion of apelin in the POA induced significant lordosis at 120 and 240 min. These results indicate that apelin-13 acts preferably in HVM and slightly in POA to initiate lordosis behavior in estrogen-primed rats.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22019172
003      
CZ-PrNML
005      
20220804135415.0
007      
ta
008      
220720s2022 ie f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.neulet.2022.136518 $2 doi
035    __
$a (PubMed)35150776
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ie
100    1_
$a García-Juárez, Marcos $u Centro de Investigación en Reproducción Animal, Universidad Autónoma de Tlaxcala-CINVESTAV, Tlaxcala, Mexico
245    10
$a Apelin-13 facilitates lordosis behavior following infusions to the ventromedial hypothalamus or preoptic area in ovariectomized, estrogen-primed rats / $c M. García-Juárez, A. Luna-Hernández, S. Tapia-Hernández, O. Montes-Narvaez, R. Domínguez-Ordoñez, MB. Tecamachaltzi-Silvarán, JG. Pfaus, O. González-Flores
520    9_
$a In normal hormonal conditions, increased neuronal activity in the ventromedial hypothalamus (VMH) induces lordosis whereas activation of the preoptic area (POA) exerts an opposite effect. In the present work, we explored the effect of bilateral infusion of different doses of the apelin-13 (0.37, 0.75, 1.5, and 15 μg) in both brain areas on the expression of lordosis behavior. Lordosis quotient and lordosis reflex score were performed at 30, 120, and 240 min. Weak lordosis was observed following the 0.37 μg dose of apelin-13 at 30 min in the VMH of EB-primed rats; however, the rest of the doses induced significant lordosis relative to the control group. At 120 min, all doses induced lordosis behavior, while at 240 min, the highest dose of 15 μg did not induce significant differences. Interestingly, only the 0.75 μg infusion of apelin in the POA induced significant lordosis at 120 and 240 min. These results indicate that apelin-13 acts preferably in HVM and slightly in POA to initiate lordosis behavior in estrogen-primed rats.
650    _2
$a zvířata $7 D000818
650    _2
$a estradiol $x farmakologie $7 D004958
650    _2
$a estrogeny $x farmakologie $7 D004967
650    _2
$a hypothalamus $x účinky léků $x patologie $7 D007031
650    12
$a mezibuněčné signální peptidy a proteiny $x farmakologie $7 D036341
650    12
$a lordóza $x chemicky indukované $7 D008141
650    12
$a area praeoptica $x účinky léků $x patologie $7 D011301
650    _2
$a progesteron $x farmakologie $7 D011374
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a sexuální chování zvířat $x účinky léků $7 D012726
650    _2
$a nucleus ventromedialis hypothalami $x účinky léků $x patologie $7 D014697
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Luna-Hernández, Ailyn $u Centro de Investigación en Reproducción Animal, Universidad Autónoma de Tlaxcala-CINVESTAV, Tlaxcala, Mexico; Maestría en Ciencias Biológicas, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico
700    1_
$a Tapia-Hernández, Sandra $u Centro de Investigación en Reproducción Animal, Universidad Autónoma de Tlaxcala-CINVESTAV, Tlaxcala, Mexico; Maestría en Ciencias Biológicas, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico
700    1_
$a Montes-Narvaez, Omar $u Centro de Investigación en Reproducción Animal, Universidad Autónoma de Tlaxcala-CINVESTAV, Tlaxcala, Mexico; Doctorado en Ciencias Biológicas, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico
700    1_
$a Domínguez-Ordoñez, Raymundo $u Centro de Investigación en Reproducción Animal, Universidad Autónoma de Tlaxcala-CINVESTAV, Tlaxcala, Mexico
700    1_
$a Tecamachaltzi-Silvarán, Miriam B $u Facultad de Ciencias para el Desarrollo Humano, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico
700    1_
$a Pfaus, James G $u Department of Psychology and Life Sciences, Charles University, Prague, and Czech National Institute of Mental Health, Klecany, Czech Republic
700    1_
$a González-Flores, Oscar $u Centro de Investigación en Reproducción Animal, Universidad Autónoma de Tlaxcala-CINVESTAV, Tlaxcala, Mexico. Electronic address: oglezflo@gmail.com
773    0_
$w MED00003507 $t Neuroscience letters $x 1872-7972 $g Roč. 773, č. - (2022), s. 136518
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35150776 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220720 $b ABA008
991    __
$a 20220804135409 $b ABA008
999    __
$a ok $b bmc $g 1822673 $s 1170415
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 773 $c - $d 136518 $e 20220209 $i 1872-7972 $m Neuroscience letters $n Neurosci. lett. $x MED00003507
LZP    __
$a Pubmed-20220720

Najít záznam

Citační ukazatele

Možnosti archivace