Apelin-13 facilitates lordosis behavior following infusions to the ventromedial hypothalamus or preoptic area in ovariectomized, estrogen-primed rats
Jazyk angličtina Země Irsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
35150776
DOI
10.1016/j.neulet.2022.136518
PII: S0304-3940(22)00075-1
Knihovny.cz E-zdroje
- Klíčová slova
- Apelin-13, Lordosis, Preoptic area, Ventromedial hypothalamus,
- MeSH
- area praeoptica * účinky léků patologie MeSH
- estradiol farmakologie MeSH
- estrogeny farmakologie MeSH
- hypothalamus účinky léků patologie MeSH
- krysa rodu Rattus MeSH
- lordóza * chemicky indukované MeSH
- mezibuněčné signální peptidy a proteiny * farmakologie MeSH
- nucleus ventromedialis hypothalami účinky léků patologie MeSH
- progesteron farmakologie MeSH
- sexuální chování zvířat účinky léků MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- apelin-13 peptide MeSH Prohlížeč
- estradiol MeSH
- estrogeny MeSH
- mezibuněčné signální peptidy a proteiny * MeSH
- progesteron MeSH
In normal hormonal conditions, increased neuronal activity in the ventromedial hypothalamus (VMH) induces lordosis whereas activation of the preoptic area (POA) exerts an opposite effect. In the present work, we explored the effect of bilateral infusion of different doses of the apelin-13 (0.37, 0.75, 1.5, and 15 μg) in both brain areas on the expression of lordosis behavior. Lordosis quotient and lordosis reflex score were performed at 30, 120, and 240 min. Weak lordosis was observed following the 0.37 μg dose of apelin-13 at 30 min in the VMH of EB-primed rats; however, the rest of the doses induced significant lordosis relative to the control group. At 120 min, all doses induced lordosis behavior, while at 240 min, the highest dose of 15 μg did not induce significant differences. Interestingly, only the 0.75 μg infusion of apelin in the POA induced significant lordosis at 120 and 240 min. These results indicate that apelin-13 acts preferably in HVM and slightly in POA to initiate lordosis behavior in estrogen-primed rats.
Citace poskytuje Crossref.org
