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Ventilation management and outcomes in out-of-hospital cardiac arrest: a protocol for a preplanned secondary analysis of the TTM2 trial
C. Robba, N. Nielsen, J. Dankiewicz, R. Badenes, D. Battaglini, L. Ball, I. Brunetti, WG. Pedro David, P. Young, G. Eastwood, MS. Chew, J. Jakobsen, J. Unden, M. Thomas, M. Joannidis, A. Nichol, A. Lundin, J. Hollenberg, G. Lilja, NE. Hammond, M....
Jazyk angličtina Země Velká Británie
Typ dokumentu protokol klinické studie, časopisecké články
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- MeSH
- dospělí MeSH
- hospitalizace MeSH
- jednotky intenzivní péče MeSH
- lidé MeSH
- randomizované kontrolované studie jako téma MeSH
- umělé dýchání MeSH
- zástava srdce mimo nemocnici * terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- protokol klinické studie MeSH
INTRODUCTION: Mechanical ventilation is a fundamental component in the management of patients post cardiac arrest. However, the ventilator settings and the gas-exchange targets used after cardiac arrest may not be optimal to minimise post-anoxic secondary brain injury. Therefore, questions remain regarding the best ventilator management in such patients. METHODS AND ANALYSIS: This is a preplanned analysis of the international randomised controlled trial, targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (OHCA)-target temperature management 2 (TTM2). The primary objective is to describe ventilatory settings and gas exchange in patients who required invasive mechanical ventilation and included in the TTM2 trial. Secondary objectives include evaluating the association of ventilator settings and gas-exchange values with 6 months mortality and neurological outcome. Adult patients after an OHCA who were included in the TTM2 trial and who received invasive mechanical ventilation will be eligible for this analysis. Data collected in the TTM2 trial that will be analysed include patients' prehospital characteristics, clinical examination, ventilator settings and arterial blood gases recorded at hospital and intensive care unit (ICU) admission and daily during ICU stay. ETHICS AND DISSEMINATION: The TTM2 study has been approved by the regional ethics committee at Lund University and by all relevant ethics boards in participating countries. No further ethical committee approval is required for this secondary analysis. Data will be disseminated to the scientific community by abstracts and by original articles submitted to peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT02908308.
Department of Anaesthesia University Hospitals Bristol NHS Foundation Trust Bristol UK
Department of Anaesthesiology and Intensive Care Medicine University of Gothenburg Gothenburg Sweden
Department of Clinical Medicine Anaesthesiology and Intensive Care Lund University Lund Sweden
Department of Clinical Sciences Lund University Lund Sweden
Department of Critical Care George Institute for Global Health Newtown New South Wales Australia
Department of Intensive Care Faculty of Health Deakin University Burwood Victoria Australia
Department of Intensive Care Medicine Hopital Erasme Université Libre de Bruxelles Brussels Belgium
Department of Intensive Care Wellington Hospital Wellington New Zealand
Department of Medicine Center for Resuscitation Science Karolinska Institutet Solna Sweden
Department of Medicine University of Barcelona Barcelona Spain Genoa Italy
Department of of Clinical Sciences Lund Lund University Lund Sweden
Department of Operation and Intensive Care Hallands Hospital Halmstad Halland Sweden
Dipartimento di Scienze Chirurgiche e Diagnostiche Università degli Studi di Genova Genoa Italy
Dipartimento di Scienze Chirurgiche e Diagnostiche University of Genoa Genoa Italy
Monash University Melbourne Victoria Australia Melbourne Ireland
Citace poskytuje Crossref.org
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