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Translating results from the cardiovascular outcomes trials with glucagon-like peptide-1 receptor agonists into clinical practice: Recommendations from a Eastern and Southern Europe diabetes expert group

A. Janez, E. Muzurovic, AP. Stoian, M. Haluzik, C. Guja, L. Czupryniak, L. Duvnjak, N. Lalic, T. Tankova, P. Bogdanski, N. Papanas, JS. Nunes, P. Kempler, Z. Fras, M. Rizzo

. 2022 ; 365 (-) : 8-18. [pub] 20220726

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22024206

Glucagon-like peptide-1 (GLP-1) receptor agonists mimic the action of the endogenous GLP-1 incretin hormone, improving glycaemic control in type 2 diabetes mellitus (T2DM) by increasing insulin secretion and decreasing glucagon secretion in a glucose-dependent manner. However, as cardiovascular (CV) morbidity and mortality is common in patients with T2DM, several trials with the use of GLP-1 receptor agonists (RAs) have been performed focusing on endpoints related to cardiovascular disease rather than metabolic control of T2DM. Following the positive cardiovascular effects of liraglutide, dulaglutide and semaglutide observed in these trials, major changes in T2DM management guidelines have occurred. This document from a Eastern and Southern European Diabetes Expert Group discusses the results of GLP-1 RA CV outcomes trials, their impact on recent clinical guidelines for the management of T2DM, and some selected combination regimens utilising GLP-1 RAs. We also propose an algorithm for guiding GLP-1 RA-based treatment according to patients' characteristics, which can be easily applied in every day clinical practice.

1st Department of Medicine Semmelweis University Budapest Hungary

Department of Diabetes Nutrition and Metabolic Diseases Carol Davila University of Medicine and Pharmacy Bucharest Romania

Department of Diabetology and Internal Medicine Medical University of Warsaw Poland

Department of Endocrinology Diabetes and Metabolic Diseases University Medical Center Ljubljana Slovenia

Department of Endocrinology Diabetes and Metabolism Centro Hospitalar Universitário Lisboa Central Lisbon Portugal

Department of Endocrinology Medical University Sofia Bulgaria

Department of Health Promotion Mother and Child Care Internal Medicine and Medical Specialties School of Medicine University of Palermo Italy

Department of Treatment of Obesity Metabolic Disorders and Clinical Dietetics University of Medical Sciences Poznan Poland

Diabetes Centre 2nd Department of Internal Medicine Democritus University of Thrace Alexandroupolis Greece

Diabetes Centre and Centre for Experimental Medicine Institute for Clinical and Experimental Medicine and Institute of Endocrinology Prague Czech Republic

Diabetes Nutrition and Metabolic Diseases Department Carol Davila University of Medicine and Pharmacy Bucharest Romania

Faculty of Medicine University of Belgrade Clinic for Endocrinology Diabetes and Metabolic Diseases Clinical Center of Serbia Belgrade Serbia

Faculty of Medicine University of Montenegro Department of Internal Medicine Endocrinology Section Clinical Centre of Montenegro Podgorica Montenegro

Preventive Cardiology Unit Division of Medicine University Medical Centre Ljubljana and Chair of Internal Medicine Medical Faculty University of Ljubljana Slovenia

School of Medicine University of Zagreb Vuk Vrhovac University Clinic Zagreb Croatia

Citace poskytuje Crossref.org

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