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Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: Data from the EuroSpA collaboration
LM. Ørnbjerg, L. Linde, S. Georgiadis, SH. Rasmussen, U. Lindström, J. Askling, B. Michelsen, DD. Giuseppe, JK. Wallman, K. Pavelka, J. Závada, MJ. Nissen, GT. Jones, H. Relas, L. Pirilä, M. Tomšič, Z. Rotar, AJ. Geirsson, B. Gudbjornsson, EK....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- ankylózující spondylitida * farmakoterapie MeSH
- axiální spondyloartritida * MeSH
- inhibitory TNF terapeutické užití MeSH
- lidé MeSH
- registrace MeSH
- spondylartritida * farmakoterapie MeSH
- stupeň závažnosti nemoci MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVES: In patients with axial spondyloarthritis (axSpA) initiating their first tumor necrosis factor alpha-inhibitor (TNFi), we aimed to identify common baseline predictors of Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) inactive disease (primary objective) and clinically important improvement (CII) at 6 months, and drug retention at 12-months across 15 European registries. METHODS: Baseline demographic and clinical characteristics were collected. Outcomes were investigated per registry and in pooled data using logistic regression analyses on multiply imputed data. RESULTS: The consistency of baseline predictors in individual registries justified pooling the data. In the pooled dataset (n = 21,196), the 6-month rates for ASDAS inactive disease and ASDAS CII were 26% and 51%, and the 12-month drug retention rate 65% in patients with available data (n = 9,845, n = 6,948 and n = 21,196, respectively). Nine common baseline predictors of ASDAS inactive disease, ASDAS CII and 12-month drug retention were identified, and the odds ratios (95%-confidence interval) for ASDAS inactive disease were: age, per year: 0.97 (0.97-0.98), men vs. women: 1.88 (1.60-2.22), current vs. non-smoking: 0.76 (0.63-0.91), HLA-B27 positive vs. negative: 1.51 (1.20-1.91), TNF start year 2015-2018 vs. 2009-2014: 1.24 (1.06-1.45), CRP>10 vs. ≤10 mg/l: 1.49 (1.25-1.77), one unit increase in health assessment questionnaire (HAQ): 0.77 (0.58-1.03), one-millimeter (mm) increase in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) fatigue and spinal pain: 0.99 (0.99-1.00) and 0.99 (0.99-1.99), respectively CONCLUSION: Common baseline predictors of treatment response and adherence to TNFi could be identified across data from 15 European registries, indicating that they may be universal across different axSpA populations.
Aberdeen Centre for Arthritis and Musculoskeletal Health University of Aberdeen Aberdeen UK
Centre for Rheumatology Research Landspitali University Hospital Reykjavik Iceland
Clinical Epidemiology Division Department of Medicine Solna Karolinska Institutet Stockholm Sweden
DANBIO registry Rigshospitalet Glostrup Denmark
Department of Clinical Medicine Aarhus University Aarhus Denmark
Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
Department of Internal Medicine Department of Clinical Medicine University of Turku Turku Finland
Department of Medicine Solna Karolinska Institutet Stockholm Sweden
Department of Rheumatology 1st Faculty of Medicine Charles University Prague Czech Republic
Department of Rheumatology Aarhus University Hospital Aarhus Denmark
Department of Rheumatology East Tallinn Central Hospital Tallinn Estonia
Department of Rheumatology Geneva University Hospital Geneva Switzerland
Department of Rheumatology Radboud UMC Nijmegen the Netherlands
Department of Rheumatology University Hospital Reykjavik Iceland
Department of Rheumatology University Hospital Zurich University of Zurich Zurich Switzerland
Department of Rheumatology University Medical Centre Ljubljana Ljubljana Slovenia
Division of Rheumatology and Research Diakonhjemmet Hospital Oslo Norway
Division of Rheumatology Department of Medicine Celal Bayar University Hospital Manisa Turkey
EpiDoc Unit Nova Medical School Lisbon Portugal
Faculty of Medicine University of Iceland Reykjavik Iceland
Faculty of Medicine University of Ljubljana Ljubljana Slovenia
Institute of Rheumatology Prague Czech Republic
Instituto Português de Reumatologia Lisbon Portugal
Reuma pt Sociedade Portuguesa de Reumatologia Lisbon Portugal
Rheumatology Unit Department of Medical and Surgical Sciences University of Foggia Italy
Rheumatology Unit DETO University of Bari Bari Italy
Serviço de Reumatologia Hospital Garcia de Orta Almada Portugal
Citace poskytuje Crossref.org
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