-
Something wrong with this record ?
Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields
B. Botzanowski, MJ. Donahue, MS. Ejneby, AL. Gallina, I. Ngom, F. Missey, E. Acerbo, D. Byun, R. Carron, AM. Cassarà, E. Neufeld, V. Jirsa, PS. Olofsson, ED. Głowacki, A. Williamson
Language English Country Germany
Document type Journal Article
Grant support
716867
European Union's Horizon 2020 research and innovation program
949191
European Union's Horizon 2020 research and innovation program
city council of Brno
Czech Republic
MedTechLabs
Swedish Research Council
European Research Council - International
European Research Council - International
- MeSH
- Electric Stimulation MeSH
- Mice MeSH
- Sciatic Nerve physiology MeSH
- Transcutaneous Electric Nerve Stimulation * methods MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high-frequency sine-wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 - 4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on-skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically-approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques.
EMUNE AB Nanna Svartz väg 6A Solna 171 65 Sweden
Institut de Neurosciences des Systèmes INSERM UMR_1106 Aix Marseille Université Marseille France
Laboratory of Organic Electronics Campus Norrköping Linköping University Norrköping Sweden
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22024494
- 003
- CZ-PrNML
- 005
- 20221031100350.0
- 007
- ta
- 008
- 221017s2022 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1002/adhm.202200075 $2 doi
- 035 __
- $a (PubMed)35751364
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Botzanowski, Boris $u Institut de Neurosciences des Systèmes (INS), INSERM, UMR_1106, Aix-Marseille Université, Marseille, France
- 245 10
- $a Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields / $c B. Botzanowski, MJ. Donahue, MS. Ejneby, AL. Gallina, I. Ngom, F. Missey, E. Acerbo, D. Byun, R. Carron, AM. Cassarà, E. Neufeld, V. Jirsa, PS. Olofsson, ED. Głowacki, A. Williamson
- 520 9_
- $a Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high-frequency sine-wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 - 4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on-skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically-approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a elektrická stimulace $7 D004558
- 650 _2
- $a myši $7 D051379
- 650 _2
- $a nervus ischiadicus $x fyziologie $7 D012584
- 650 12
- $a transkutánní elektrická neurostimulace $x metody $7 D004561
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Donahue, Mary J $u Laboratory of Organic Electronics, Campus Norrköping, Linköping University, Norrköping, Sweden
- 700 1_
- $a Ejneby, Malin Silverå $u Laboratory of Organic Electronics, Campus Norrköping, Linköping University, Norrköping, Sweden
- 700 1_
- $a Gallina, Alessandro L $u Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
- 700 1_
- $a Ngom, Ibrahima $u Institut de Neurosciences des Systèmes (INS), INSERM, UMR_1106, Aix-Marseille Université, Marseille, France
- 700 1_
- $a Missey, Florian $u Institut de Neurosciences des Systèmes (INS), INSERM, UMR_1106, Aix-Marseille Université, Marseille, France
- 700 1_
- $a Acerbo, Emma $u Institut de Neurosciences des Systèmes (INS), INSERM, UMR_1106, Aix-Marseille Université, Marseille, France
- 700 1_
- $a Byun, Donghak $u Laboratory of Organic Electronics, Campus Norrköping, Linköping University, Norrköping, Sweden
- 700 1_
- $a Carron, Romain $u Institut de Neurosciences des Systèmes (INS), INSERM, UMR_1106, Aix-Marseille Université, Marseille, France
- 700 1_
- $a Cassarà, Antonino M $u Foundation for Research on Information Technologies in Society (IT'IS), Zeughaustrasse 43, Zurich, 8004, Switzerland $1 https://orcid.org/https://orcid.org/0000000333757440
- 700 1_
- $a Neufeld, Esra $u Foundation for Research on Information Technologies in Society (IT'IS), Zeughaustrasse 43, Zurich, 8004, Switzerland $1 https://orcid.org/https://orcid.org/0000000155286147
- 700 1_
- $a Jirsa, Viktor $u Institut de Neurosciences des Systèmes (INS), INSERM, UMR_1106, Aix-Marseille Université, Marseille, France
- 700 1_
- $a Olofsson, Peder S $u Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden $u EMUNE AB, Nanna Svartz väg 6A, Solna, 171 65, Sweden
- 700 1_
- $a Głowacki, Eric Daniel $u Bioelectronics Materials and Devices Lab, Central European Institute of Technology, Brno University of Technology, Purkyňova 123, Brno, 61200, Czech Republic $1 https://orcid.org/https://orcid.org/0000000202808017
- 700 1_
- $a Williamson, Adam $u Institut de Neurosciences des Systèmes (INS), INSERM, UMR_1106, Aix-Marseille Université, Marseille, France $u Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
- 773 0_
- $w MED00189489 $t Advanced healthcare materials $x 2192-2659 $g Roč. 11, č. 17 (2022), s. e2200075
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35751364 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20221017 $b ABA008
- 991 __
- $a 20221031100348 $b ABA008
- 999 __
- $a ok $b bmc $g 1854290 $s 1175784
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 11 $c 17 $d e2200075 $e 20220707 $i 2192-2659 $m Advanced healthcare materials $n Adv Healthc Mater $x MED00189489
- GRA __
- $a 716867 $p European Union's Horizon 2020 research and innovation program
- GRA __
- $a 949191 $p European Union's Horizon 2020 research and innovation program
- GRA __
- $p city council of Brno
- GRA __
- $p Czech Republic
- GRA __
- $p MedTechLabs
- GRA __
- $p Swedish Research Council
- GRA __
- $p European Research Council $2 International
- GRA __
- $p European Research Council $2 International
- LZP __
- $a Pubmed-20221017
