• Je něco špatně v tomto záznamu ?

Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug

J. Kasparkova, H. Kostrhunova, V. Novohradsky, L. Ma, G. Zhu, ER. Milaeva, AA. Shtill, R. Vinck, G. Gasser, V. Brabec, AA. Nazarov

. 2022 ; 14 (7) : . [pub] 20220720

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22025180

This work studied the mechanism of action of a Pt(IV) complex 2 bearing two axial lonidamine ligands, which are selective inhibitors of aerobic glycolysis. The presence of two lonidamine ligands in 2 compared to the parent Pt(II) complex increased its antiproliferative activity, cellular accumulation, and changed its cell cycle profile and mechanism of cell death. In 3D cell culture, 2 showed exceptional antiproliferative activity with IC50 values as low as 1.6 μM in MCF7 cells. The study on the influence of the lonidamine ligands in the Pt complex on glycolysis showed only low potency of ligands to affect metabolic processes in cancer cells, making the investigated complex, not a dual- or multi-action prodrug. However, the Pt(IV) prodrug effectively delivers the cytotoxic Pt(II) complex into cancer cells.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22025180
003      
CZ-PrNML
005      
20221031100222.0
007      
ta
008      
221017s2022 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1093/mtomcs/mfac048 $2 doi
035    __
$a (PubMed)35759404
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Kasparkova, Jana $u Czech Academy of Sciences, Institute of Biophysics, Brno CZ-61265, Czech Republic $1 https://orcid.org/0000000252795381
245    10
$a Is antitumor Pt(IV) complex containing two axial lonidamine ligands a true dual- or multi-action prodrug / $c J. Kasparkova, H. Kostrhunova, V. Novohradsky, L. Ma, G. Zhu, ER. Milaeva, AA. Shtill, R. Vinck, G. Gasser, V. Brabec, AA. Nazarov
520    9_
$a This work studied the mechanism of action of a Pt(IV) complex 2 bearing two axial lonidamine ligands, which are selective inhibitors of aerobic glycolysis. The presence of two lonidamine ligands in 2 compared to the parent Pt(II) complex increased its antiproliferative activity, cellular accumulation, and changed its cell cycle profile and mechanism of cell death. In 3D cell culture, 2 showed exceptional antiproliferative activity with IC50 values as low as 1.6 μM in MCF7 cells. The study on the influence of the lonidamine ligands in the Pt complex on glycolysis showed only low potency of ligands to affect metabolic processes in cancer cells, making the investigated complex, not a dual- or multi-action prodrug. However, the Pt(IV) prodrug effectively delivers the cytotoxic Pt(II) complex into cancer cells.
650    12
$a protinádorové látky $x farmakologie $7 D000970
650    _2
$a nádorové buněčné linie $7 D045744
650    _2
$a indazoly $7 D007191
650    _2
$a ligandy $7 D008024
650    12
$a prekurzory léčiv $x farmakologie $7 D011355
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Kostrhunova, Hana $u Czech Academy of Sciences, Institute of Biophysics, Brno CZ-61265, Czech Republic
700    1_
$a Novohradsky, Vojtech $u Czech Academy of Sciences, Institute of Biophysics, Brno CZ-61265, Czech Republic
700    1_
$a Ma, Lili $u Department of Chemistry, City University of Hong Kong, Hong Kong SAR, P. R. China
700    1_
$a Zhu, Guangyu $u Department of Chemistry, City University of Hong Kong, Hong Kong SAR, P. R. China
700    1_
$a Milaeva, Elena R $u Faculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russian Federation
700    1_
$a Shtill, Alexender A $u Blokhin Cancer Center, Russian Academy of Medical Sciences, 115478 Moscow, Russian Federation
700    1_
$a Vinck, Robin $u Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, 75005 Paris, France
700    1_
$a Gasser, Gilles $u Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, 75005 Paris, France
700    1_
$a Brabec, Viktor $u Czech Academy of Sciences, Institute of Biophysics, Brno CZ-61265, Czech Republic $1 https://orcid.org/0000000282331393
700    1_
$a Nazarov, Alexey A $u Faculty of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russian Federation $1 https://orcid.org/0000000258211658
773    0_
$w MED00181644 $t Metallomics $x 1756-591X $g Roč. 14, č. 7 (2022)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35759404 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20221017 $b ABA008
991    __
$a 20221031100220 $b ABA008
999    __
$a ok $b bmc $g 1854738 $s 1176470
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 14 $c 7 $e 20220720 $i 1756-591X $m Metallomics $n Metallomics $x MED00181644
LZP    __
$a Pubmed-20221017

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace