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Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS-STEMI COVID-19 Registry
G. De Luca, M. Algowhary, B. Uguz, DC. Oliveira, V. Ganyukov, Z. Zimbakov, M. Cercek, LO. Jensen, PH. Loh, L. Calmac, GRI. Ferrer, A. Quadros, M. Milewski, F. Scotto D'Uccio, C. von Birgelen, F. Versaci, J. Ten Berg, G. Casella, A. Wong Sung...
Status neindexováno Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2012
Free Medical Journals
od 2012
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2019-01-01
Open Access Digital Library
od 2012-01-01
Open Access Digital Library
od 2012-01-01
Health & Medicine (ProQuest)
od 2019-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2012
PubMed
36431198
DOI
10.3390/jcm11226722
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
The so-called "smoking paradox", conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history.
Azienda Ospedaliero Universitaria Ospedali Riuniti 34142 Trieste Italy
Cardiology Azienda Ospedaliera 16033 Lavagna Italy
Cardiology Center Hospitalier d'Antibes Juan Les Pins 06600 Antibes France
Cardiology Complexo Hospetaliero Universitario La Coruna 15001 La Coruna Spain
Cardiology Department Hospital Garcia de Orta 2805 267 Almada Portugal
Cardiology Hospital Clínico Universitario Virgen de la Victoria 29000 Malaga Spain
Cardiology Hospital Germans Triasi Pujol 8918 Badalona Spain
Cardiology Institute Instanbul University 34000 Instanbul Turkey
Cardiology Iraklion University Hospital 70001 Crete Greece
Cardiology Maastricht University Medical Center 6229 Maastricht The Netherlands
Cardiology University Hospital Prague 12808 Prague Czech Republic
Center for Cardiovascular Diseases 6000 Ohrid North Macedonia
Central Hospital of Medical University of Lodz 90 008 Lodz Poland
Centre for Intensive Internal Medicine University Medical Centre 1000 Ljubljana Slovenia
Clinic Emergency Hospital of Bucharest 010001 Bucharest Romania
Department of Cardiology Bezmialem Vakif University Hospital 34093 Istanbul Turkey
Department of Cardiology Medisch Spectrum Twente Thoraxcentrum Twente 7541 Enschede The Netherlands
Department of Cardiology National Heart Center Singapore 169609 Singapore
Department of Cardiology National University Hospital Singapore 117597 Singapore
Department of Cardiology Queen Elizabeth Hospital University of Hong Kong Hong Kong 999077 China
Department of Cardiology Queen Mary Hospital University of Hong Kong Hong Kong 999077 China
Department of Cardiology University Hospital Centre University of Zagreb 10000 Zagreb Croatia
Department of Internal Medicine Ospedale Riuniti 25121 Brescia Italy
Department of Statistical Sciences University of Padova 35121 Padova Italy
Division of Cardiology Alexandra Hospital 10431 Athens Greece
Division of Cardiology Assiut University Heart Hospital Assiut University Asyut 71511 Egypt
Division of Cardiology Attikon University Hospital 10431 Athens Greece
Division of Cardiology AUSL IRCCS Reggio Emilia 42121 Reggio Emilia Italy
Division of Cardiology Azienda Ospedaliera Ospedali Riuniti Marche Nord 61121 Pesaro Italy
Division of Cardiology Blida University Hospital Blida 09000 Algeria
Division of Cardiology Bursa City Hospital 16000 Bursa Turkey
Division of Cardiology Center Hospitalier Universitaire de Lille 59000 Lille France
Division of Cardiology CHU Lariboisière AP HP INSERM UMRS 942 Paris 7 University 75010 Paris France
Division of Cardiology Clinica Villa dei Fiori 80011 Acerra Italy
Division of Cardiology Complejo Hospitalario de Toledo 45001 Toledo Spain
Division of Cardiology Faculty of Medicine Eskisehir Osmangazi University 02640 Eskisehir Turkey
Division of Cardiology Groupe Hospitalier Mutualiste de Grenoble 38000 Grenoble France
Division of Cardiology Heart Centre Turku 20521 Turku Finland
Division of Cardiology Hopital Erasmus Universitè Libre de Bruxelles 1070 Bruxelles Belgium
Division of Cardiology Hospiatl Cordoba Cordoba 5000 Argentina
Division of Cardiology Hospital Cabueñes 33201 Gijon Spain
Division of Cardiology Hospital Clinico Universitario de Valencia 46010 Valencia Spain
Division of Cardiology Hospital de Santo António 4099 001 Porto Portugal
Division of Cardiology Hospital Puerta de Hierro Majadahonda 28222 Madrid Spain
Division of Cardiology Hospital Puerta del Mar 11001 Cadiz Spain
Division of Cardiology Hospital Universitario de Canarias 38001 Santa Cruz de Tenerife Spain
Division of Cardiology Kontantopoulion Hospital 104 31 Athens Greece
Division of Cardiology Medical University of Silezia 40 002 Katowice Poland
Division of Cardiology Northwest Clinics 1811 Alkmaar The Netherlands
Division of Cardiology Odense Universitets Hospital 5000 Odense Denmark
Division of Cardiology Ospedale A Manzoni 23900 Lecco Italy
Division of Cardiology Ospedale Civico Arnas 90100 Palermo Italy
Division of Cardiology Ospedale Degli Infermi ASL Biella 13900 Biella Italy
Division of Cardiology Ospedale del Mare 00156 Napoli Italy
Division of Cardiology Ospedale F Spaziani 03100 Frosinone Italy
Division of Cardiology Ospedale G Moscati 81031 Aversa Italy
Division of Cardiology Ospedale Maggiore Bologna 40100 Bologna Italy
Division of Cardiology Ospedale S Maurizio 39100 Bolzano Italy
Division of Cardiology Ospedale San Giovanni di Dio e Ruggi d'Aragona 84070 Salerno Italy
Division of Cardiology Ospedale Sant'Anna 44121 Ferrara Italy
Division of Cardiology Ospedale Santa Chiara di Trento 38014 Trento Italy
Division of Cardiology Ospedale Santa Maria delle Grazie 80078 Pozzuoli Italy
Division of Cardiology Ospedale Santa Maria Goretti Latina 04100 Latina Italy
Division of Cardiology Otamendi Hospital Buenos Aires 1001 Argentina
Division of Cardiology Oulu University Hospital 90220 Oulu Finland
Division of Cardiology Radboud University Medical Center 6525 Nijmegen The Netherlands
Division of Cardiology St Antonius Hospital 3434 Nieuwegein The Netherlands
Division of Cardiology UMC Utrecht 3584 CX Utrecht The Netherlands
Division of Cardiology Universidad UPB CES Medellin 050001 Colombia
H Universitario y Politécnico La Fe 46001 Valencia Spain
Instituto Cardiovascular de Buenos Aires Buenos Aires 1428 Argentina
Instituto de Cardiologia de Santa Catarina Praia Comprida Sao Jose 88100 000 Brazil
Instituto de Cardiologia do Rio Grande do Sul Porto Alegre 90000 00 Brazil
Instituto de Cardiologia Integral Montevideo 11700 Uruguay
Interventional Cardiology Unit Azienda Ospedaliera Sanitaria 43121 Parma Italy
Interventional Cardiology Unit Azienda Ospedaliero Universitaria Ospedali Riuniti 60100 Ancona Italy
Invasive Cardiology and Congenital Heart Disease Patras University Hospital 26221 Patras Greece
Tyumen Cardiology Research Center 625026 Tyumen Russia
University Hospital Brno Medical Faculty of Masaryk University Brno 60200 Brno Czech Republic
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- $a The so-called "smoking paradox", conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS-STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history.
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