-
Je něco špatně v tomto záznamu ?
Infective endocarditis in adult patients with congenital heart disease
JP. van Melle, JW. Roos-Hesselink, M. Bansal, O. Kamp, M. Meshaal, J. Pudich, VR. Luksic, R. Rodriguez-Alvarez, A. Sadeghpour, JS. Hanzevacki, R. Sow, AT. Timóteo, MT. Morgado, M. De Bonis, C. Laroche, E. Boersma, P. Lancellotti, G. Habib,...
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
- MeSH
- bakteriální endokarditida * diagnóza epidemiologie komplikace MeSH
- dospělí MeSH
- endokarditida * diagnóza epidemiologie etiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- prospektivní studie MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- vrozené srdeční vady * komplikace diagnóza epidemiologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Congenital Heart Disease (CHD) predisposes to Infective Endocarditis (IE), but data about characterization and prognosis of IE in CHD patients is scarce. METHODS: The ESC-EORP-EURO-ENDO study is a prospective international study in IE patients (n = 3111). In this pre-specified analysis, adult CHD patients (n = 365, 11.7%) are described and compared with patients without CHD (n = 2746) in terms of baseline characteristics and mortality. RESULTS: CHD patients (73% men, age 44.8 ± 16.6 years) were younger and had fewer comorbidities. Of the CHD patients, 14% had a dental procedure before hospitalization versus 7% in non-CHD patients (p < 0.001) and more often had positive blood cultures for Streptococcus viridans (16.4% vs 8.8%, p < 0.001). As in non-CHD patients, IE most often affected the left-sided valves. For CHD patients, in-hospital mortality was 9.0% vs 18.1% in non-CHD patients (p < 0.001), and also, during the entire follow-up of 700 days, survival was more favorable (log-rank p < 0.0001), even after adjustment for age, gender and major comorbidities (Hazard Ratio (HR) 0.68; 95%CI 0.50-0.92). Within the CHD population, multivariable Cox regression revealed the following effects (HR and [95% CI]) on mortality: fistula (HR 6.97 [3.36-14.47]), cerebral embolus (HR 4.64 [2.08-10.35]), renal insufficiency (HR 3.44 [1.48-8.02]), Staphylococcus aureus as causative agent (HR 2.06 [1.11-3.81]) and failure to undertake surgery when indicated (HR 5.93 [3.15-11.18]). CONCLUSIONS: CHD patients with IE have a better outcome in terms of all-cause mortality. The observed high incidence of dental procedures prior to IE warrants further studies about the current use, need and efficacy of antibiotic prophylaxis in CHD patients.
Cardiac Surgery IRCCS San Raffaele University Hospital Milan Italy
Cardiology Department Santa Cruz Hospital Centro Hospitalar de Lisboa Ocidental Lisbon Portugal
Department of Cardiology Erasmus MC Rotterdam the Netherlands
Department of Cardiology Laboratory of Echocardiography Luxembourg Hospital Centre Luxembourg
Duke Cardiovascular MR Center Durham NC United States of America
Echocardiography Research Center Rajaie Cardiovascular Medical and Research Center Tehran Iran
Gruppo Villa Maria Care and Research Maria Cecilia Hospital Cotignola Anthea Hospital Bari Italy
Infectious Diseases Unit Cruces University Hospital Barakaldo Spain
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22032049
- 003
- CZ-PrNML
- 005
- 20230131151535.0
- 007
- ta
- 008
- 230120s2023 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ijcard.2022.10.136 $2 doi
- 035 __
- $a (PubMed)36273665
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a van Melle, Joost P $u Center for Congenital Heart Diseases, Department of Cardiology, University Medical Center Groningen, University of Groningen, the Netherlands. Electronic address: j.p.van.melle@umcg.nl
- 245 10
- $a Infective endocarditis in adult patients with congenital heart disease / $c JP. van Melle, JW. Roos-Hesselink, M. Bansal, O. Kamp, M. Meshaal, J. Pudich, VR. Luksic, R. Rodriguez-Alvarez, A. Sadeghpour, JS. Hanzevacki, R. Sow, AT. Timóteo, MT. Morgado, M. De Bonis, C. Laroche, E. Boersma, P. Lancellotti, G. Habib, EURO-ENDO Investigators Group
- 520 9_
- $a BACKGROUND: Congenital Heart Disease (CHD) predisposes to Infective Endocarditis (IE), but data about characterization and prognosis of IE in CHD patients is scarce. METHODS: The ESC-EORP-EURO-ENDO study is a prospective international study in IE patients (n = 3111). In this pre-specified analysis, adult CHD patients (n = 365, 11.7%) are described and compared with patients without CHD (n = 2746) in terms of baseline characteristics and mortality. RESULTS: CHD patients (73% men, age 44.8 ± 16.6 years) were younger and had fewer comorbidities. Of the CHD patients, 14% had a dental procedure before hospitalization versus 7% in non-CHD patients (p < 0.001) and more often had positive blood cultures for Streptococcus viridans (16.4% vs 8.8%, p < 0.001). As in non-CHD patients, IE most often affected the left-sided valves. For CHD patients, in-hospital mortality was 9.0% vs 18.1% in non-CHD patients (p < 0.001), and also, during the entire follow-up of 700 days, survival was more favorable (log-rank p < 0.0001), even after adjustment for age, gender and major comorbidities (Hazard Ratio (HR) 0.68; 95%CI 0.50-0.92). Within the CHD population, multivariable Cox regression revealed the following effects (HR and [95% CI]) on mortality: fistula (HR 6.97 [3.36-14.47]), cerebral embolus (HR 4.64 [2.08-10.35]), renal insufficiency (HR 3.44 [1.48-8.02]), Staphylococcus aureus as causative agent (HR 2.06 [1.11-3.81]) and failure to undertake surgery when indicated (HR 5.93 [3.15-11.18]). CONCLUSIONS: CHD patients with IE have a better outcome in terms of all-cause mortality. The observed high incidence of dental procedures prior to IE warrants further studies about the current use, need and efficacy of antibiotic prophylaxis in CHD patients.
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a prospektivní studie $7 D011446
- 650 _2
- $a rizikové faktory $7 D012307
- 650 12
- $a endokarditida $x diagnóza $x epidemiologie $x etiologie $7 D004696
- 650 12
- $a bakteriální endokarditida $x diagnóza $x epidemiologie $x komplikace $7 D004697
- 650 12
- $a vrozené srdeční vady $x komplikace $x diagnóza $x epidemiologie $7 D006330
- 650 _2
- $a retrospektivní studie $7 D012189
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Roos-Hesselink, Jolien W $u Department of Cardiology, Erasmus MC, Rotterdam, the Netherlands
- 700 1_
- $a Bansal, Manish $u Medanta, The Medicity, Gurgaon, Haryana 120001, India
- 700 1_
- $a Kamp, Otto $u Amsterdam UMC, Vrije Universiteit Amsterdam, Cardiology, Amsterdam Cardiovascular Sciences, the Netherlands
- 700 1_
- $a Meshaal, Marwa $u Department of Cardiology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Cairo 11562, Egypt
- 700 1_
- $a Pudich, Jiri $u Department of Cardiovascular Diseases, University Hospital Ostrava, University of Ostrava, Faculty of Medicine, Czech Republic
- 700 1_
- $a Luksic, Vlatka Reskovic $u Department of Cardiovascular Diseases, University of Zagreb, School of Medicine and University Hospital Centre Zagreb, Croatia
- 700 1_
- $a Rodriguez-Alvarez, Regino $u Infectious Diseases Unit, Cruces University Hospital, Barakaldo, Spain
- 700 1_
- $a Sadeghpour, Anita $u Echocardiography Research Center, Rajaie Cardiovascular Medical & Research Center, Tehran, Iran; Duke Cardiovascular MR Center, Durham, NC, United States of America
- 700 1_
- $a Hanzevacki, Jadranka Separovic $u Department of Cardiovascular Diseases, University of Zagreb, School of Medicine and University Hospital Centre Zagreb, Croatia
- 700 1_
- $a Sow, Rouguiatou $u Department of Cardiology, Laboratory of Echocardiography, Luxembourg Hospital Centre, Luxembourg
- 700 1_
- $a Timóteo, Ana Teresa $u Cardiology Department, Santa Marta Hospital, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
- 700 1_
- $a Morgado, Marisa Trabulo $u Cardiology Department, Santa Cruz Hospital, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal
- 700 1_
- $a De Bonis, Michele $u Cardiac Surgery, IRCCS San Raffaele University Hospital, Milan, Italy
- 700 1_
- $a Laroche, Cecile $u EURObservational Research Programme, European Society of Cardiology, Heart House. 2035 Route des Colles, CS80179 Biot, 06903 Sophia-Antipolis, France
- 700 1_
- $a Boersma, Eric $u Department of Cardiology, Erasmus MC, Rotterdam, the Netherlands
- 700 1_
- $a Lancellotti, Patrizio $u University of Liège Hospital, GIGA Cardiovascular Sciences, Department of Cardiology, CHU Sart Tilman, Liège, Belgium; Gruppo Villa Maria Care and Research, Maria Cecilia Hospital, Cotignola, Anthea Hospital, Bari, Italy
- 700 1_
- $a Habib, Gilbert $u La Timone Hospital, Cardiology Department, Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France
- 710 2_
- $a EURO-ENDO Investigators Group
- 773 0_
- $w MED00002299 $t International journal of cardiology $x 1874-1754 $g Roč. 370, č. - (2023), s. 178-185
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/36273665 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230120 $b ABA008
- 991 __
- $a 20230131151531 $b ABA008
- 999 __
- $a ok $b bmc $g 1891054 $s 1183384
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 370 $c - $d 178-185 $e 20221021 $i 1874-1754 $m International journal of cardiology $n Int J Cardiol $x MED00002299
- LZP __
- $a Pubmed-20230120
