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Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer's disease? An updated meta-analysis
P. Šimko, JA. Kent, I. Rektorova
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, metaanalýza, systematický přehled
- MeSH
- Alzheimerova nemoc * terapie psychologie MeSH
- kognice MeSH
- kognitivní dysfunkce * terapie psychologie MeSH
- lidé MeSH
- mozek fyziologie MeSH
- přímá transkraniální stimulace mozku * metody MeSH
- transkraniální magnetická stimulace metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- systematický přehled MeSH
OBJECTIVE: Alzheimer's disease dementia (AD) and its preclinical stage, mild cognitive impairment (MCI), are critical issues confronting the aging society. Non-invasive brain stimulation (NIBS) techniques have the potential to be effective tools for enhancing cognitive functioning. The main objective of our meta-analysis was to quantify and update the status of the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) and Transcranial Direct Current Stimulation (tDCS) when applied in AD and MCI. METHODS: The systematic literature search was conducted in PubMed and Web of Science according to PRISMA statement. RESULTS: Pooled effect sizes (Hedges' g) from 32 studies were analyzed using random effect models. We found both, rTMS and tDCS to have significant immediate cognition-enhancing effect in AD with rTMS inducing also beneficial long-term effects. We found no evidence for synergistic effect of cognitive training with NIBS. CONCLUSIONS: In AD a clinical recommendation can be made for NEURO-ADTM system and for high-frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC) as probably effective protocols (B-level of evidence) and for anodal tDCS over the left DLPFC as a possibly effective. SIGNIFICANCE: According to scientific literature, NIBS may be an effective method for improving cognition in AD and possibly in MCI.
Citace poskytuje Crossref.org
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- $a Šimko, Patrik $u Central European Institute of Technology, CEITEC, Masaryk University, Applied Neuroscience Research Group, Brno, Czech Republic; 1(st) Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic
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- $a OBJECTIVE: Alzheimer's disease dementia (AD) and its preclinical stage, mild cognitive impairment (MCI), are critical issues confronting the aging society. Non-invasive brain stimulation (NIBS) techniques have the potential to be effective tools for enhancing cognitive functioning. The main objective of our meta-analysis was to quantify and update the status of the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) and Transcranial Direct Current Stimulation (tDCS) when applied in AD and MCI. METHODS: The systematic literature search was conducted in PubMed and Web of Science according to PRISMA statement. RESULTS: Pooled effect sizes (Hedges' g) from 32 studies were analyzed using random effect models. We found both, rTMS and tDCS to have significant immediate cognition-enhancing effect in AD with rTMS inducing also beneficial long-term effects. We found no evidence for synergistic effect of cognitive training with NIBS. CONCLUSIONS: In AD a clinical recommendation can be made for NEURO-ADTM system and for high-frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC) as probably effective protocols (B-level of evidence) and for anodal tDCS over the left DLPFC as a possibly effective. SIGNIFICANCE: According to scientific literature, NIBS may be an effective method for improving cognition in AD and possibly in MCI.
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- $a Kent, Julia Anna $u Faculty of Medicine, Masaryk University, Brno, Czech Republic
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- $a Rektorova, Irena $u Central European Institute of Technology, CEITEC, Masaryk University, Applied Neuroscience Research Group, Brno, Czech Republic; 1(st) Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic; International Clinical Research Center, ICRC, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: irena.rektorova@fnusa.cz
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