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Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses
JL. Kalman, T. Yoshida, TFM. Andlauer, EC. Schulte, K. Adorjan, M. Alda, R. Ardau, JM. Aubry, K. Brosch, M. Budde, C. Chillotti, PM. Czerski, RJ. DePaulo, A. Forstner, FS. Goes, M. Grigoroiu-Serbanescu, P. Grof, D. Grotegerd, T. Hahn, M....
Language English Country Germany
Document type Journal Article
NLK
ProQuest Central
from 1997-02-01 to 1 year ago
Medline Complete (EBSCOhost)
from 1998-02-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-02-01 to 1 year ago
- MeSH
- Depressive Disorder, Major * psychology MeSH
- Mental Health MeSH
- Phenotype MeSH
- Humans MeSH
- Personality genetics MeSH
- Suicidal Ideation * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.
Center for Mind Brain and Behavior University of Marburg Marburg Germany
Centre for Human Genetics University of Marburg Marburg Germany
Centro de Investigación Biomedica en Red de Salud Mental Barcelona Spain
Department of Biomedical Sciences University of Cagliari Cagliari Italy
Department of Psychiatric Genetics Poznan University of Medical Sciences Poznan Poland
Department of Psychiatry and Behavioral Sciences SUNY Upstate Medical University Syracuse NY USA
Department of Psychiatry and Psychotherapy University Hospital Munich Munich Germany
Department of Psychiatry and Psychotherapy University of Marburg Marburg Germany
Department of Psychiatry Dalhousie University Halifax Canada
Department of Psychiatry Geneva University Hospitals Geneva Switzerland
Department of Psychiatry University of California San Diego La Jolla CA USA
Department of Psychiatry University of Toronto Toronto ON Canada
Faculty of Medicine University of Geneva Geneva Switzerland
Institute for Translational Neuroscience University of Münster Munster Germany
Institute for Translational Psychiatry University of Munster Munster Germany
Institute of Neuroscience and Medicine Research Centre Jülich Jülich Germany
International Max Planck Research School for Translational Psychiatry Munich Germany
Montreal Neurological Institute McGill University Montreal Canada
Mood Disorders Clinic of Ottawa Ottawa ON Canada
National Center for Global Health and Medicine Tokyo Japan
National Institute of Mental Health Klecany Czech Republic
Psychiatric Genetics Research Unit Alexandru Obregia Clinical Psychiatric Hospital Bucharest Romania
Rd Faculty of Medicine Charles University Prague Czech Republic
The Douglas Research Centre McGill University Montreal Canada
Unit of Clinical Pharmacology University Hospital Agency of Cagliari Cagliari Italy
References provided by Crossref.org
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- $a Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses / $c JL. Kalman, T. Yoshida, TFM. Andlauer, EC. Schulte, K. Adorjan, M. Alda, R. Ardau, JM. Aubry, K. Brosch, M. Budde, C. Chillotti, PM. Czerski, RJ. DePaulo, A. Forstner, FS. Goes, M. Grigoroiu-Serbanescu, P. Grof, D. Grotegerd, T. Hahn, M. Heilbronner, R. Hasler, U. Heilbronner, S. Heilmann-Heimbach, P. Kapelski, T. Kato, MO. Kohshour, S. Meinert, T. Meller, I. Nenadić, MM. Nöthen, T. Novak, N. Opel, J. Pawlak, JK. Pfarr, JB. Potash, D. Reich-Erkelenz, J. Repple, H. Richard-Lepouriel, M. Rietschel, KG. Ringwald, G. Rouleau, S. Schaupp, F. Senner, G. Severino, A. Squassina, F. Stein, P. Stopkova, F. Streit, K. Thiel, F. Thomas-Odenthal, G. Turecki, J. Twarowska-Hauser, A. Winter, PP. Zandi, JR. Kelsoe, Consortium on Lithium Genetics (ConLiGen), PsyCourse, P. Falkai, U. Dannlowski, T. Kircher, TG. Schulze, S. Papiol
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