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Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment

AHC. Anthis, MP. Abundo, AL. Neuer, E. Tsolaki, J. Rosendorf, T. Rduch, FHL. Starsich, B. Weisse, V. Liska, AA. Schlegel, MG. Shapiro, IK. Herrmann

. 2022 ; 13 (1) : 7311. [pub] 20221127

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22032579

Millions of patients every year undergo gastrointestinal surgery. While often lifesaving, sutured and stapled reconnections leak in around 10% of cases. Currently, surgeons rely on the monitoring of surrogate markers and clinical symptoms, which often lack sensitivity and specificity, hence only offering late-stage detection of fully developed leaks. Here, we present a holistic solution in the form of a modular, intelligent suture support sealant patch capable of containing and detecting leaks early. The pH and/or enzyme-responsive triggerable sensing elements can be read out by point-of-need ultrasound imaging. We demonstrate reliable detection of the breaching of sutures, in as little as 3 hours in intestinal leak scenarios and 15 minutes in gastric leak conditions. This technology paves the way for next-generation suture support materials that seal and offer disambiguation in cases of anastomotic leaks based on point-of-need monitoring, without reliance on complex electronics or bulky (bio)electronic implantables.

Citace poskytuje Crossref.org

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$a Anthis, Alexandre H C $u Nanoparticle Systems Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092, Zurich, Switzerland $u Laboratory for Particles Biology Interactions, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014, St. Gallen, Switzerland
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$a Millions of patients every year undergo gastrointestinal surgery. While often lifesaving, sutured and stapled reconnections leak in around 10% of cases. Currently, surgeons rely on the monitoring of surrogate markers and clinical symptoms, which often lack sensitivity and specificity, hence only offering late-stage detection of fully developed leaks. Here, we present a holistic solution in the form of a modular, intelligent suture support sealant patch capable of containing and detecting leaks early. The pH and/or enzyme-responsive triggerable sensing elements can be read out by point-of-need ultrasound imaging. We demonstrate reliable detection of the breaching of sutures, in as little as 3 hours in intestinal leak scenarios and 15 minutes in gastric leak conditions. This technology paves the way for next-generation suture support materials that seal and offer disambiguation in cases of anastomotic leaks based on point-of-need monitoring, without reliance on complex electronics or bulky (bio)electronic implantables.
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$a Abundo, Maria Paulene $u Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA
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$a Neuer, Anna L $u Nanoparticle Systems Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092, Zurich, Switzerland $u Laboratory for Particles Biology Interactions, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014, St. Gallen, Switzerland $1 https://orcid.org/0000000257624709
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$a Tsolaki, Elena $u Nanoparticle Systems Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092, Zurich, Switzerland $u Laboratory for Particles Biology Interactions, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014, St. Gallen, Switzerland
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$a Rosendorf, Jachym $u Department of Surgery, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic $1 https://orcid.org/0000000321250685
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$a Rduch, Thomas $u Laboratory for Particles Biology Interactions, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014, St. Gallen, Switzerland $u Department of Gynaecology, Cantonal Hospital St Gallen (KSSG), Rorschacherstrasse 95, CH-9007, St Gallen, Switzerland $1 https://orcid.org/0000000274865002
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$a Starsich, Fabian H L $u Nanoparticle Systems Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092, Zurich, Switzerland $u Laboratory for Particles Biology Interactions, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014, St. Gallen, Switzerland
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$a Weisse, Bernhard $u Laboratory for Mechanical Systems Engineering, Department of Engineering Sciences, Empa - Swiss Laboratories for Materials Science and Technology, Ueberlandstrasse 129, CH-8600, Dübendorf, Switzerland $1 https://orcid.org/0000000252675777
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$a Liska, Vaclav $u Department of Surgery, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic $u Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic
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$a Schlegel, Andrea A $u Department of Visceral Surgery and Transplantation, University Hospital Zurich, CH-8091, Zurich, Switzerland $u Swiss HPB and Transplant Center, Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland $u Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Centre of Preclinical Research, Milan, 20122, Italy
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$a Shapiro, Mikhail G $u Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, USA $u Howard Hughes Medical Institute, Pasadena, CA, 91125, USA $1 https://orcid.org/0000000202914215
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$a Herrmann, Inge K $u Nanoparticle Systems Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, CH-8092, Zurich, Switzerland. ingeh@ethz.ch $u Laboratory for Particles Biology Interactions, Department Materials Meet Life, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, CH-9014, St. Gallen, Switzerland. ingeh@ethz.ch $1 https://orcid.org/0000000230186796
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