Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Protection by Vaccines and Previous Infection Against the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2

M. Šmíd, L. Berec, L. Přibylová, O. Májek, T. Pavlík, J. Jarkovský, J. Weiner, T. Barusová, J. Trnka

. 2022 ; 226 (8) : 1385-1390. [pub] 2022Oct17

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22033056

BACKGROUND: The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades immunity conferred by vaccines and previous infections. METHODS: We used a Cox proportional hazards model and a logistic regression on individual-level population-wide data from the Czech Republic to estimate risks of infection and hospitalization, including severe states. RESULTS: A recent (≤2 months) full vaccination reached vaccine effectiveness (VE) of 43% (95% confidence interval [CI], 42%-44%) against infection by Omicron compared to 73% (95% CI, 72%-74%) against Delta. A recent booster increased VE to 56% (95% CI, 55%-56%) against Omicron infection compared to 90% (95% CI, 90%-91%) for Delta. The VE against Omicron hospitalization of a recent full vaccination was 45% (95% 95% CI, 29%-57%), with a recent booster 87% (95% CI, 84%-88%). The VE against the need for oxygen therapy due to Omicron was 57% (95% CI, 32%-72%) for recent vaccination, 90% (95% CI, 87%-92%) for a recent booster. Postinfection protection against Omicron hospitalization declined from 68% (95% CI, 68%-69%) at ≤6 months to 13% (95% CI, 11%-14%) at >6 months after a previous infection. The odds ratios for Omicron relative to Delta were 0.36 (95% CI, .34-.38) for hospitalization, 0.24 (95% CI, .22-.26) for oxygen, and 0.24 (95% CI, .21-.28) for intensive care unit admission. CONCLUSIONS: Recent vaccination still brings substantial protection against severe outcome for Omicron.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22033056
003      
CZ-PrNML
005      
20240117121112.0
007      
ta
008      
230120s2022 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1093/infdis/jiac161 $2 doi
035    __
$a (PubMed)35482442
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Šmíd, Martin $u Institute of Information Theory and Automation, Czech Academy of Sciences, Prague, Czech Republic $u Centre for Modelling of Biological and Social Processes, Prague, Czech Republic $1 https://orcid.org/0000000311403510
245    10
$a Protection by Vaccines and Previous Infection Against the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 / $c M. Šmíd, L. Berec, L. Přibylová, O. Májek, T. Pavlík, J. Jarkovský, J. Weiner, T. Barusová, J. Trnka
520    9_
$a BACKGROUND: The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades immunity conferred by vaccines and previous infections. METHODS: We used a Cox proportional hazards model and a logistic regression on individual-level population-wide data from the Czech Republic to estimate risks of infection and hospitalization, including severe states. RESULTS: A recent (≤2 months) full vaccination reached vaccine effectiveness (VE) of 43% (95% confidence interval [CI], 42%-44%) against infection by Omicron compared to 73% (95% CI, 72%-74%) against Delta. A recent booster increased VE to 56% (95% CI, 55%-56%) against Omicron infection compared to 90% (95% CI, 90%-91%) for Delta. The VE against Omicron hospitalization of a recent full vaccination was 45% (95% 95% CI, 29%-57%), with a recent booster 87% (95% CI, 84%-88%). The VE against the need for oxygen therapy due to Omicron was 57% (95% CI, 32%-72%) for recent vaccination, 90% (95% CI, 87%-92%) for a recent booster. Postinfection protection against Omicron hospitalization declined from 68% (95% CI, 68%-69%) at ≤6 months to 13% (95% CI, 11%-14%) at >6 months after a previous infection. The odds ratios for Omicron relative to Delta were 0.36 (95% CI, .34-.38) for hospitalization, 0.24 (95% CI, .22-.26) for oxygen, and 0.24 (95% CI, .21-.28) for intensive care unit admission. CONCLUSIONS: Recent vaccination still brings substantial protection against severe outcome for Omicron.
650    12
$a COVID-19 $x prevence a kontrola $7 D000086382
650    _2
$a lidé $7 D006801
650    _2
$a SARS-CoV-2 $7 D000086402
650    _2
$a vakcinace $7 D014611
650    12
$a vakcíny $7 D014612
655    _2
$a časopisecké články $7 D016428
700    1_
$a Berec, Luděk $u Centre for Modelling of Biological and Social Processes, Prague, Czech Republic $u Centre for Mathematical Biology, Institute of Mathematics, Faculty of Science, University of South Bohemia, Budjovice, Czech Republic $u Biology Centre, Institute of Entomology, Department of Ecology, Czech Academy of Sciences, Budjovice, Czech Republic
700    1_
$a Přibylová, Lenka $u Department of Mathematics and Statistics, Faculty of Science, Masaryk University, Brno, Czech Republic
700    1_
$a Májek, Ondřej $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Department of Data Analysis, Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic
700    1_
$a Pavlík, Tomáš $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Department of Data Analysis, Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic
700    1_
$a Jarkovský, Jiří $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic $u Department of Data Analysis, Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic
700    1_
$a Weiner, Jakub $u Institute of Information Theory and Automation, Czech Academy of Sciences, Prague, Czech Republic $u Centre for Modelling of Biological and Social Processes, Prague, Czech Republic
700    1_
$a Barusová, Tamara $u First Faculty of Medicine, Charles University, Prague, Czech Republic $u Department of Statistical Modelling, Czech Academy of Sciences, Institute of Computer Science, Prague, Czech Republic $7 xx0312819
700    1_
$a Trnka, Jan $u Department of Biochemistry, Cell and Molecular Biology, Third Faculty of Medicine, Charles University, Prague, Czech Republic
773    0_
$w MED00002745 $t The Journal of infectious diseases $x 1537-6613 $g Roč. 226, č. 8 (2022), s. 1385-1390
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35482442 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230120 $b ABA008
991    __
$a 20240117121108 $b ABA008
999    __
$a ok $b bmc $g 1891680 $s 1184391
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2022 $b 226 $c 8 $d 1385-1390 $e 2022Oct17 $i 1537-6613 $m The Journal of infectious diseases $n J Infect Dis $x MED00002745
LZP    __
$a Pubmed-20230120

Najít záznam

Citační ukazatele

Možnosti archivace