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Role of stem cell transplant in CD30+ PTCL following frontline brentuximab vedotin plus CHP or CHOP in ECHELON-2
KJ. Savage, SM. Horwitz, R. Advani, JH. Christensen, E. Domingo-Domenech, G. Rossi, F. Morschhauser, O. Alpdogan, C. Suh, K. Tobinai, A. Shustov, M. Trneny, S. Yuen, PL. Zinzani, L. Trümper, T. Ilidge, OA. O'Connor, B. Pro, H. Miao, V. Bunn, K....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, randomizované kontrolované studie, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
P30 CA008748
NCI NIH HHS - United States
NLK
PubMed Central
od 2016
Europe PubMed Central
od 2016
Elsevier Open Access Journals
od 2021-10-26
ROAD: Directory of Open Access Scholarly Resources
od 2016
- MeSH
- anaplastický velkobuněčný lymfom * chemicky indukované terapie MeSH
- antigen Ki-1 MeSH
- brentuximab vedotin MeSH
- cyklofosfamid škodlivé účinky MeSH
- doxorubicin škodlivé účinky MeSH
- lidé MeSH
- lokální recidiva nádoru MeSH
- prednison škodlivé účinky MeSH
- transplantace hematopoetických kmenových buněk * MeSH
- vinkristin škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
- Research Support, N.I.H., Extramural MeSH
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of aggressive non-Hodgkin lymphomas, the majority of which have high relapse rates following standard therapy. Despite use of consolidative stem cell transplant (SCT) following frontline therapy, there remains no consensus on its utility. The double-blind randomized phase 3 ECHELON-2 study (#NCT01777152; clinicaltrials.gov) demonstrated improved progression-free survival (PFS) and overall survival with frontline brentuximab vedotin plus cyclophosphamide, doxorubicin, and prednisone (A+CHP). Herein, we conducted an exploratory subgroups analysis of the impact of consolidative SCT on PFS in patients with previously untreated CD30+ PTCL (ALK- anaplastic large cell lymphoma [ALCL] and non-ALCL) who were in complete response (CR) after frontline treatment with A+CHP or cyclophosphamide, doxorubicin, vincristine, and prednisone. Median PFS follow-up was 47.57 months. The PFS hazard ratio was 0.36, equating to a 64% reduction in the risk of a PFS event in patients who underwent SCT. The median PFS in patients who underwent SCT was not reached, vs 55.66 months in patients who did not undergo SCT. PFS results favored the use of SCT in both ALK- ALCL and non-ALCL subgroups. These data support the consideration of consolidative SCT in patients with CD30+PTCL who achieve CR following treatment with A+CHP.
Azienda Ospedaliera Spedali Civili di Brescia Brescia Italy
Blood and Marrow Transplant Program Stanford Cancer Center Stanford CA
Calvary Mater Newcastle Hospital Waratah NSW Australia
Department of Haematology Odense University Hospital Odense Denmark
Department of Hematology and Medical Oncology Universitätsmedizin Göttingen Göttingen Germany
Hematology Division National Cancer Center Hospital Tokyo Japan
Institut Catala D'oncologia L'Hospitalet de Llobregat Barcelona Spain
MD Anderson Cancer Center University of Texas Houston TX
Memorial Sloan Kettering Cancer Center New York NY
Millennium Pharmaceuticals Inc Cambridge MA
NewYork Presbyterian Columbia University Irving Medical Center New York NY
Citace poskytuje Crossref.org
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