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Invasive Trichoderma spp. infections: clinical presentation and outcome of cases from the literature and the FungiScope® registry
E. Sal, J. Stemler, J. Salmanton-García, I. Falces-Romero, L. Kredics, E. Meyer, B. Würstl, C. Lass-Flörl, Z. Racil, N. Klimko, S. Cesaro, AJ. Kindo, H. Wisplinghoff, P. Koehler, OA. Cornely, D. Seidel
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, systematický přehled, práce podpořená grantem
NLK
Free Medical Journals
od 1996 do Před 1 rokem
Open Access Digital Library
od 1996-01-01
PubMed
35929089
DOI
10.1093/jac/dkac235
Knihovny.cz E-zdroje
- MeSH
- amfotericin B terapeutické užití MeSH
- antifungální látky terapeutické užití MeSH
- hematologické nádory * komplikace MeSH
- kaspofungin MeSH
- lidé MeSH
- registrace MeSH
- Trichoderma * MeSH
- vorikonazol terapeutické užití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- systematický přehled MeSH
BACKGROUND: Trichoderma spp. are filamentous fungi causing invasive fungal diseases in patients with haematological malignancies and in peritoneal dialysis patients. OBJECTIVES: To analyse clinical presentation, predisposing factors, treatment and outcome of Trichoderma infections. METHODS: A systematic literature review was conducted for published cases of invasive Trichoderma infection in PubMed until December 2021 and by reviewing the included studies' references. Cases from the FungiScope® registry were added to a combined analysis. RESULTS: We identified 50 invasive infections due to Trichoderma species, including 11 in the FungiScope® registry. The main underlying conditions were haematological malignancies in 19 and continuous ambulatory peritoneal dialysis (CAPD) in 10 cases. The most prevalent infection sites were lung (42%) and peritoneum (22%). Systemic antifungal therapy was administered in 42 cases (84%), mostly amphotericin B (n = 27, lipid-based formulation 13/27) and voriconazole in 15 cases (30%). Surgical interventions were performed in 13 cases (26%). Overall mortality was 48% (n = 24) and highest for allogeneic HSCT and solid organ transplantation (SOT) recipients [80% (4/5) and 77% (7/9), respectively]. In patients treated with amphotericin B, voriconazole and caspofungin, mortality was 55% (15/27), 46% (7/15) and 28% (2/7), respectively. Three out of four patients treated with a combination therapy of voriconazole and caspofungin survived. CONCLUSIONS: Despite treatment with antifungal therapies and surgery, invasive Trichoderma infections are life-threatening complications in immunocompromised patients, especially after HSCT and SOT. In addition, Trichoderma spp. mainly affect the lungs in patients with haematological malignancies and the peritoneum in CAPD patients.
Clinical Microbiology and Parasitology Department University Hospital La Paz Madrid Spain
Department of Microbiology Faculty of Science and Informatics University of Szeged Szeged Hungary
Department of Physiology Faculty of Medicine Masaryk University Brno Czech Republic
German Centre for Infection Research Partner Site Bonn Cologne Cologne Germany
Institute of Haematology and Blood Transfusion Prague Czech Republic
Pediatric Haematology Oncology Azienda Ospedaliera Universitaria Integrata Verona Verona Italy
Stabsstelle Krankenhaushygiene und Infektionsprävention München Klinik München Germany
Citace poskytuje Crossref.org
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