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Propolis-induced hepatorenoprotection in rodents exposed to rifampicin and isoniazid
Ahmed Abdulsallam, Imad A. Thanoon, Abdulrahman I. Abduljabbar
Language English Country Czech Republic
Digital library NLK
Source
NLK
ROAD: Directory of Open Access Scholarly Resources
from 2011
- MeSH
- Antitubercular Agents antagonists & inhibitors adverse effects MeSH
- Blood Chemical Analysis methods instrumentation MeSH
- Biomedical Research MeSH
- Histological Techniques MeSH
- Isoniazid antagonists & inhibitors adverse effects MeSH
- Rats * MeSH
- Microscopy MeSH
- Models, Animal MeSH
- Liver Diseases prevention & control MeSH
- Kidney Diseases prevention & control MeSH
- Drug-Related Side Effects and Adverse Reactions drug therapy therapy MeSH
- Propolis * pharmacology MeSH
- Rifampin antagonists & inhibitors adverse effects MeSH
- Check Tag
- Rats * MeSH
- Geographicals
- Iraq MeSH
The elimination of most drugs based on liver/renal excretion; making liver and kidneys the commonest target organ for exposure to toxic materials. Long-term use of drugs surpassed the effect and aggravate the toxicity. Tuberculosis (TB) is chronic disease with long-term therapy and the deleterious impact of antitubelculosis is certain. Various pharmacokinetic manoveuors were proposed to avoid the potential harmful effect of TB therapy. The present study aimed at mitigating the destructive effects of TB therapy using propolis. To do so, rats were exposed to isoniazid or rifampicin or a combination of them in groups of 8 rats each for a period of 8-weeks these groups were matched with similar group with a propolis ad-on therapy. These results were compared to propolis-free negative control group and positive propolis-treated group. The histological and laboratory findings confirmed that isoniazid or rifampicin or a combination of them jeopardized hepatorenal function and induced deleterious damage. However, isoniazid has shown more intensive deleterious effect compared to rifampicin. Nonetheless, propolis restore the quasi-equilibrium status for kidney and liver via restoring its normal architecture and functionality. To sum up, the potential defect of anti-TB was restored via using propolis as add-on therapy, we do advise using propolis as an adjuvant TB therapy in critically-ill and clinical cases required long-term TB therapy.
Alkhansaa Teaching hospital Mosul Ninevah Province Iraq
College of Medicine University of Mosul Mosul Ninevah Province Iraq
Graduated Physician University of Mosul Mosul Ninevah Province Iraq
References provided by Crossref.org
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