The main health care challenges associated with diabetic patients are glycemic control. Insulin defection has been regarded as the mainstay which needs to be tackled to avoid glucose over presence in the circulatory system. These challenges have always been conjoined with the patient's redox status, hence, oxidants/antioxidants determine the fate of pancreatic tissue status and they are reciprocally interrelated. Various remedies have been utilized by patients themselves and healthcare workers to control hyperglycemia if any. Herbal and pharmacological therapy were always being used hand in hand. Herein, we are demonstrating the antioxidant effect of propolis and its role in modulation of lipid profile in type 2 diabetic patients using vitamin E for comparison in sequential mode i.e. vitamin E used for 8 weeks followed one-week washout period and then propolis therapy started in the same group of patients (n = 45). Thereby a sample of serum has been collected in the first visit (baseline and vitamin E started, followed by collecting serum after 8 weeks (second visit); followed by commencing of propolis after a washout week from the second visit, at the third visit another serum sample collected from all patients. Serum was analyzed for oxidant/antioxidant status represented by malondialdehyde (MDA) and total antioxidant status (TAS). Additionally, lipid profile has been measured from the same samples. The results indicate that both propolis and vitamin E positively modulated the measured parameters with superiority of propolis over vitamin E in improving these measured biomolecules. To conclude, propolis is an overall safe natural product and is inducing such positive effects in the diabetic patient, we do advise these patients to start propolis therapy as an adjuvant medication to control these deleterious biomolecules.
- MeSH
- biochemická analýza krve metody přístrojové vybavení MeSH
- diabetes mellitus 2. typu * farmakoterapie krev MeSH
- kombinace léků sitagliptin a metformin aplikace a dávkování MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipidy krev MeSH
- malondialdehyd krev MeSH
- oxidační stres účinky léků MeSH
- propolis aplikace a dávkování farmakologie MeSH
- statistika jako téma MeSH
- vitamin E aplikace a dávkování farmakologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- Publikační typ
- klinická studie MeSH
- Geografické názvy
- Irák MeSH
The elimination of most drugs based on liver/renal excretion; making liver and kidneys the commonest target organ for exposure to toxic materials. Long-term use of drugs surpassed the effect and aggravate the toxicity. Tuberculosis (TB) is chronic disease with long-term therapy and the deleterious impact of antitubelculosis is certain. Various pharmacokinetic manoveuors were proposed to avoid the potential harmful effect of TB therapy. The present study aimed at mitigating the destructive effects of TB therapy using propolis. To do so, rats were exposed to isoniazid or rifampicin or a combination of them in groups of 8 rats each for a period of 8-weeks these groups were matched with similar group with a propolis ad-on therapy. These results were compared to propolis-free negative control group and positive propolis-treated group. The histological and laboratory findings confirmed that isoniazid or rifampicin or a combination of them jeopardized hepatorenal function and induced deleterious damage. However, isoniazid has shown more intensive deleterious effect compared to rifampicin. Nonetheless, propolis restore the quasi-equilibrium status for kidney and liver via restoring its normal architecture and functionality. To sum up, the potential defect of anti-TB was restored via using propolis as add-on therapy, we do advise using propolis as an adjuvant TB therapy in critically-ill and clinical cases required long-term TB therapy.
- MeSH
- antituberkulotika antagonisté a inhibitory škodlivé účinky MeSH
- biochemická analýza krve metody přístrojové vybavení MeSH
- biomedicínský výzkum MeSH
- histologické techniky MeSH
- isoniazid antagonisté a inhibitory škodlivé účinky MeSH
- krysa rodu rattus * MeSH
- mikroskopie MeSH
- modely u zvířat MeSH
- nemoci jater prevence a kontrola MeSH
- nemoci ledvin prevence a kontrola MeSH
- nežádoucí účinky léčiv farmakoterapie terapie MeSH
- propolis * farmakologie MeSH
- rifampin antagonisté a inhibitory škodlivé účinky MeSH
- Check Tag
- krysa rodu rattus * MeSH
- Geografické názvy
- Irák MeSH
Respirační infekce jsou jedno z nejčastějších infekčních onemocnění postihující jak děti, tak i dospělé. Kašel jako symptom nemocí z nachlazení může procházet fází suchého kašle, kterou střídá fáze produktivního kašle. U dětí je vhodné se vyvarovat centrálně působících antitusik, z periferních antitusik se jako nejvhodnější jeví použití levodropropizinu, u produktivního kašle probíhá dlouhodobě diskuze a přehodnocování přínosů jednotlivých mukomodulačních léčiv, dle doporučení je preferován erdostein. Z tradičních prostředků je i předními experty doporučován med a přípravky na bázi medových sirupů k ovlivnění frekvence a intenzity kašle u dětí.
Respiratory infections are one of the most common infectious diseases affecting both children and adults. Cough, as a symptom of a cold illness, can go through a phase of dry cough which alternates with a phase of productive cough. In children, it is advisable to avoid centrally acting antitussives. The use of levodropropizine seems to be the most suitable of peripheral antitussives. For productive cough there is a long-term discussion and reassessment of the benefits of mucomodulatory drugs. According to recommendations, erdostein is recommended. From traditional medicine it is recommended even by leading experts to use honey and preparations based on honey syrups to influence the frequency and intensity of cough in children.
- Klíčová slova
- levodropropizin, ERDOSTEIN,
- MeSH
- akutní nemoc MeSH
- antitusika terapeutické užití MeSH
- biologické přípravky terapeutické užití MeSH
- dítě MeSH
- expektorancia terapeutické užití MeSH
- infekce dýchací soustavy diagnóza farmakoterapie MeSH
- kašel * diagnóza farmakoterapie MeSH
- kodein terapeutické užití MeSH
- lidé MeSH
- med MeSH
- propolis terapeutické užití MeSH
- randomizované kontrolované studie jako téma MeSH
- směrnice pro lékařskou praxi jako téma MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
Data on the substantial physiological role of the immune system in the organism's ability to manage proper differentiation and function of normal tissues (tissue homeostasis), and detailed causes of the immune system's essential role for the in-vivo stimulation of cancer growth, are severely lacking. This results in a lack of effective cancer immunotherapy without adverse events, and in the lack of long-lasting cancer immune prophylaxes, particularly in ovarian cancers. Elimination of blood auto-antibodies blocking anti-cancer T cell effectors by intermittent moderate doses of cyclophosphamide, facilitation of the immune system reactivity against alloantigens of cancer cells by two subsequent blood transfusions, and augmentation of anticancer immunity by weekly intradermal injections of bacterial toxins, caused during the subsequent treatment-free period, lasting for two to four weeks, regression of inoperable epithelial ovarian cancers and regeneration of the tremendously metastatically altered abdominal tissues into normal healthy conditions without multivisceral cytoreductive surgery, which can result in life-threatening consequences. An otherwise untreated rectal cancer, progressing over 3 years, regressed after severe toxic dermatitis lasting over one week. This was caused by an accidental consumption of a large raw shiitake mushroom. Subsequent daily consumptions of 2 g Metformin ER and honeybee propolis ethanol extract, and weekly single larger raw shiitake mushroom, which all stimulate immune system reactivity against cancer stem cells, prevented malignant recurrence over the next 29 years without recurring dermatitis, and maintained healthy organism's conditions. These observations indicate that regression of advanced inoperable cancers and long-lasting cancer immune prophylaxis can be reached by simple approaches.
- MeSH
- autoprotilátky imunologie MeSH
- epiteliální ovariální karcinom imunologie patologie terapie MeSH
- homeostáza MeSH
- houby šii-take MeSH
- imunitní systém MeSH
- imunoterapie metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- lokální recidiva nádoru MeSH
- metformin terapeutické užití MeSH
- nádory rekta imunologie patologie terapie MeSH
- nádory vaječníků imunologie patologie terapie MeSH
- proliferace buněk MeSH
- propolis MeSH
- T-lymfocyty imunologie MeSH
- včely MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- přehledy MeSH
Honey bees are major pollinators of crops with high economic value. Thus, bees are considered to be the most important nontarget organisms exposed to adverse effects of plant protection product use. The side effects of pesticides are one of the major factors often linked to colony losses. Fewer studies have researched acute poisoning incidents in comparison to the study of the sublethal effects of pesticides. Here, we compared pesticides in dead/dying bees from suspected poisoning incidents and the suspected crop source according to government protocols. Additionally, we analyzed live bees and bee bread collected from the brood comb to determine recent in-hive contamination. We used sites with no reports of poisoning for reference. Our analysis confirmed that not all of the suspected poisonings correlated with the suspected crop. The most important pesticides related to the poisoning incidents were highly toxic chlorpyrifos, deltamethrin, cypermethrin and imidacloprid and slightly toxic prochloraz and thiacloprid. Importantly, poisoning was associated with pesticide cocktail application. Almost all poisoning incidents were investigated in relation to rapeseed. Some sites were found to be heavily contaminated with several pesticides, including a reference site. However, other sites were moderately contaminated despite agricultural use, including rapeseed cultivation sites, which can influence the extent of pesticide use, including tank mixes and other factors. We suggest that the analysis of pesticides in bee bread and in bees from the brood comb is a useful addition to dead bee and suspected crop analysis in poisoning incidents to inform the extent of recent in-hive contamination.
- MeSH
- dursban * MeSH
- insekticidy * MeSH
- pesticidy * MeSH
- propolis * MeSH
- včely MeSH
- zemědělství MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
Bee pollen is a combination of plant pollen and honeybee secretions and nectar. The Bible and ancient Egyptian texts are documented proof of its use in public health. It is considered a gold mine of nutrition due to its active components that have significant health and medicinal properties. Bee pollen contains bioactive compounds including proteins, amino acids, lipids, carbohydrates, minerals, vitamins, and polyphenols. The vital components of bee pollen enhance different bodily functions and offer protection against many diseases. It is generally marketed as a functional food with affordable and inexpensive prices with promising future industrial potentials. This review highlights the dietary properties of bee pollen and its influence on human health, and its applications in the food industry.
- MeSH
- antioxidancia analýza MeSH
- funkční potraviny * MeSH
- krevní glukóza MeSH
- krysa rodu rattus MeSH
- lidé MeSH
- metabolický syndrom MeSH
- myši MeSH
- nutriční hodnota MeSH
- propolis * MeSH
- pyl * MeSH
- sacharidy analýza MeSH
- včely * MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- MeSH
- lidé MeSH
- med * mikrobiologie MeSH
- propolis * farmakologie terapeutické užití MeSH
- Check Tag
- lidé MeSH
A lip cream with special propolis extract GH 2002 at a concentration of 0.5% (199 patients) was tested against aciclovir 5% (198 patients) in the treatment of episodes of herpes labialis under double-blind conditions. Upon inclusion, all patients were in the vesicular phase. Application was five times daily of approximately 0.2 g of cream to the entire upper and lower lip. The primary parameter was the difference in time between groups to complete encrustation or epithelization of the lesions. Secondary endpoints were the course of typical herpes symptoms (pain, burning and itching, tension and swelling), the global assessment of efficacy and the safety of application. The predefined clinical situation was reached after a (median) 3 days with propolis and 4 days with aciclovir (p < 0.0001). Significant differences in favor of propolis were also found for all secondary parameters. No allergic reactions, local irritations or other adverse events occurred.
- MeSH
- acyklovir terapeutické užití MeSH
- antivirové látky * terapeutické užití MeSH
- apiterapie metody MeSH
- dospělí MeSH
- dvojitá slepá metoda MeSH
- herpes labialis * farmakoterapie MeSH
- lidé MeSH
- propolis * terapeutické užití MeSH
- recidiva MeSH
- ret MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
Current study evaluated the synergistic potential of propolis and vitamin E against sub-acute toxicity of aluminum chloride on different biochemical parameters and liver histology. Swiss albino mice (n=42) were randomly divided into seven groups. Group I received 0.2 ml of 0.9 % saline solution, Group II received Propolis (50 mg/kg b.w.), Group III received vitamin E (150 mg/kg b.w.), Group IV received AlCl(3) 50 mg/kg b.w., Group V received AlCl(3) + Propolis, Group VI received AlCl(3) + vitamin E and Group VII received AlCl(3) + propolis + vitamin E. Blood and tissue samples were collected after 7 and 21 days. The body weight of the animals significantly increased in all groups except Group IV. The concentration of serum high density lipoprotein significantly decreased in Group IV and increased in Group V, VI and VII. The level of aspartate aminotransferase, alanine transferase, alkaline phosphatase, triglycerides, total cholesterol, and low density lipoprotein significantly increased in AlCl(3) treated group and increased in Group V, VI and VII. Tissue sections were processed and stained by hematoxylin and eosin. Group II showed cellular necrosis. Group V, VI showed decreased number of vacuolization, sinusoidal spacing and macrophage cell infiltration. Group VI showed less degenerative changes in the third week. Vitamin E and propolis in combination with Al provides more protection against AlCl(3) induced toxicity.
- MeSH
- chlorid hlinitý toxicita MeSH
- játra účinky léků patologie MeSH
- lékové postižení jater patologie prevence a kontrola MeSH
- myši MeSH
- náhodné rozdělení MeSH
- propolis aplikace a dávkování izolace a purifikace MeSH
- synergismus léků MeSH
- testy subakutní toxicity metody MeSH
- vitamin E aplikace a dávkování MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
