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Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility

P. Celichowski, M. Turi, S. Charvátová, D. Radhakrishnan, N. Feizi, Z. Chyra, M. Šimíček, T. Jelínek, JR. Bago, R. Hájek, M. Hrdinka

. 2023 ; 21 (1) : 197. [pub] 20230315

Language English Country England, Great Britain

Document type Journal Article, Review, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc23003797

Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful personalized therapeutic agents showing dramatic preclinical and clinical results, particularly in hematological malignancies. Ectopically expressed chimeric antigen receptors (CARs) reprogram immune cells to target and eliminate cancer. However, CAR T cell therapy's success depends on the balance between effective anti-tumor activity and minimizing harmful side effects. To improve CAR T cell therapy outcomes and mitigate associated toxicities, scientists from different fields are cooperating in developing next-generation products using the latest molecular cell biology and synthetic biology tools and technologies. The immunotherapy field is rapidly evolving, with new approaches and strategies being reported at a fast pace. This comprehensive literature review aims to provide an up-to-date overview of the latest developments in controlling CAR T cell activity for improved safety, efficacy, and flexibility.

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$a Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful personalized therapeutic agents showing dramatic preclinical and clinical results, particularly in hematological malignancies. Ectopically expressed chimeric antigen receptors (CARs) reprogram immune cells to target and eliminate cancer. However, CAR T cell therapy's success depends on the balance between effective anti-tumor activity and minimizing harmful side effects. To improve CAR T cell therapy outcomes and mitigate associated toxicities, scientists from different fields are cooperating in developing next-generation products using the latest molecular cell biology and synthetic biology tools and technologies. The immunotherapy field is rapidly evolving, with new approaches and strategies being reported at a fast pace. This comprehensive literature review aims to provide an up-to-date overview of the latest developments in controlling CAR T cell activity for improved safety, efficacy, and flexibility.
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$a Turi, Marcello $u Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic $u Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic $u Faculty of Science, University of Ostrava, Ostrava, Czech Republic
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$a Radhakrishnan, Dhwani $u Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic $u Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic $u Faculty of Science, University of Ostrava, Ostrava, Czech Republic
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$a Feizi, Neda $u Department of Internal Clinical Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
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