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Diagnostics in Waldenström's macroglobulinemia: a consensus statement of the European Consortium for Waldenström's Macroglobulinemia
I. Dogliotti, C. Jiménez, M. Varettoni, D. Talaulikar, T. Bagratuni, M. Ferrante, J. Pérez, D. Drandi, N. Puig, M. Gilestro, M. García-Álvarez, R. Owen, W. Jurczak, A. Tedeschi, V. Leblond, E. Kastritis, MJ. Kersten, S. D'Sa, M. Kaščák, W....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
ProQuest Central
od 1997-02-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Nursing & Allied Health Database (ProQuest)
od 1997-02-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-02-01 do Před 1 rokem
- MeSH
- hybridizace in situ fluorescenční MeSH
- imunoglobulin M MeSH
- lidé MeSH
- Waldenströmova makroglobulinemie * diagnóza MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The diagnosis of Waldenström's macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström's Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.
ASST Grande Ospedale Metropolitano Niguarda Hospital Milan Italy
Clinical Research Development and Phase 1 Unit ASST Spedali Civili di Brescia Brescia Italy
Département d'Hématologie Hôpital Pitié Salpêtrière APHP UPMC Université Paris Paris France
Division of Hematology Fondazione IRCCS Policlinico San Matteo Pavia Italy
Hematology Division 1U AOU Città della Salute e della Scienza di Torino Torino Italy
Maria Sklodowska Curie National Research Institute of Oncology Krakow Poland
National and Kapodistrian University of Athens School of Medicine Athens Greece
The Leeds Teaching Hospitals National Health Service Trust Leeds UK
Unit of Hematology Department of Biotechnology and Health Sciences University of Torino Torino Italy
Citace poskytuje Crossref.org
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- $a The diagnosis of Waldenström's macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström's Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.
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