• Je něco špatně v tomto záznamu ?

Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy

N. Daskova, M. Heczkova, I. Modos, J. Hradecky, T. Hudcovic, M. Kuzma, H. Pelantova, I. Buskova, E. Sticova, D. Funda, J. Golias, B. Drabonova, J. Jarkovska, M. Kralova, I. Cibulkova, J. Gojda, M. Cahova

. 2023 ; 15 (2) : . [pub] 20230115

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23004577

Fecal microbiota transfer may serve as a therapeutic tool for treating obesity and related disorders but currently, there is no consensus regarding the optimal donor characteristics. We studied how microbiota from vegan donors, who exhibit a low incidence of non-communicable diseases, impact on metabolic effects of an obesogenic diet and the potential role of dietary inulin in mediating these effects. Ex-germ-free animals were colonized with human vegan microbiota and fed a standard or Western-type diet (WD) with or without inulin supplementation. Despite the colonization with vegan microbiota, WD induced excessive weight gain, impaired glucose metabolism, insulin resistance, and liver steatosis. However, supplementation with inulin reversed steatosis and improved glucose homeostasis. In contrast, inulin did not affect WD-induced metabolic changes in non-humanized conventional mice. In vegan microbiota-colonized mice, inulin supplementation resulted in a significant change in gut microbiota composition and its metabolic performance, inducing the shift from proteolytic towards saccharolytic fermentation (decrease of sulfur-containing compounds, increase of SCFA). We found that (i) vegan microbiota alone does not protect against adverse effects of WD; and (ii) supplementation with inulin reversed steatosis and normalized glucose metabolism. This phenomenon is associated with the shift in microbiota composition and accentuation of saccharolytic fermentation at the expense of proteolytic fermentation.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc23004577
003      
CZ-PrNML
005      
20230425171614.0
007      
ta
008      
230418s2023 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/nu15020454 $2 doi
035    __
$a (PubMed)36678325
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Daskova, Nikola $u Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic $u First Faculty of Medicine, Charles University, Katerinska 1660/32, 12108 Prague, Czech Republic $1 https://orcid.org/0000000280388361
245    10
$a Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy / $c N. Daskova, M. Heczkova, I. Modos, J. Hradecky, T. Hudcovic, M. Kuzma, H. Pelantova, I. Buskova, E. Sticova, D. Funda, J. Golias, B. Drabonova, J. Jarkovska, M. Kralova, I. Cibulkova, J. Gojda, M. Cahova
520    9_
$a Fecal microbiota transfer may serve as a therapeutic tool for treating obesity and related disorders but currently, there is no consensus regarding the optimal donor characteristics. We studied how microbiota from vegan donors, who exhibit a low incidence of non-communicable diseases, impact on metabolic effects of an obesogenic diet and the potential role of dietary inulin in mediating these effects. Ex-germ-free animals were colonized with human vegan microbiota and fed a standard or Western-type diet (WD) with or without inulin supplementation. Despite the colonization with vegan microbiota, WD induced excessive weight gain, impaired glucose metabolism, insulin resistance, and liver steatosis. However, supplementation with inulin reversed steatosis and improved glucose homeostasis. In contrast, inulin did not affect WD-induced metabolic changes in non-humanized conventional mice. In vegan microbiota-colonized mice, inulin supplementation resulted in a significant change in gut microbiota composition and its metabolic performance, inducing the shift from proteolytic towards saccharolytic fermentation (decrease of sulfur-containing compounds, increase of SCFA). We found that (i) vegan microbiota alone does not protect against adverse effects of WD; and (ii) supplementation with inulin reversed steatosis and normalized glucose metabolism. This phenomenon is associated with the shift in microbiota composition and accentuation of saccharolytic fermentation at the expense of proteolytic fermentation.
650    _2
$a myši $7 D051379
650    _2
$a zvířata $7 D000818
650    _2
$a lidé $7 D006801
650    _2
$a fekální transplantace $7 D000069467
650    _2
$a vegani $7 D000066989
650    _2
$a inulin $x farmakologie $7 D007444
650    _2
$a potravní vláknina $x farmakologie $7 D004043
650    12
$a ztučnělá játra $x prevence a kontrola $x farmakoterapie $7 D005234
650    12
$a střevní mikroflóra $7 D000069196
650    _2
$a západní dieta $7 D066273
650    _2
$a glukosa $x farmakologie $7 D005947
655    _2
$a časopisecké články $7 D016428
700    1_
$a Heczkova, Marie $u Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic
700    1_
$a Modos, Istvan $u Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic
700    1_
$a Hradecky, Jaromir $u Faculty of Forestry and Wood Sciences, Czech University of Life Sciences, 16500 Prague, Czech Republic $1 https://orcid.org/0000000316212705
700    1_
$a Hudcovic, Tomas $u Institute of Microbiology of the CAS, 14220 Prague, Czech Republic
700    1_
$a Kuzma, Marek $u Institute of Microbiology of the CAS, 14220 Prague, Czech Republic
700    1_
$a Pelantova, Helena $u Institute of Microbiology of the CAS, 14220 Prague, Czech Republic $1 https://orcid.org/0000000225237413
700    1_
$a Buskova, Irena $u Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic
700    1_
$a Sticova, Eva $u Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic
700    1_
$a Funda, David $u Institute of Microbiology of the CAS, 14220 Prague, Czech Republic $1 https://orcid.org/0000000183276931 $7 xx0027015
700    1_
$a Golias, Jaroslav $u Institute of Microbiology of the CAS, 14220 Prague, Czech Republic
700    1_
$a Drabonova, Barbora $u Faculty of Agrobiology, Food, and Natural Resources, Czech University of Life Sciences, 16500 Prague, Czech Republic
700    1_
$a Jarkovska, Jarmila $u Institute of Microbiology of the CAS, 14220 Prague, Czech Republic
700    1_
$a Kralova, Maria $u Department of Applied Mathematics and Computer Science, Masaryk University, 60177 Brno, Czech Republic
700    1_
$a Cibulkova, Ivana $u Department of Internal Medicine, Kralovske Vinohrady University Hospital and Third Faculty of Medicine, Charles University, 10000 Prague, Czech Republic
700    1_
$a Gojda, Jan $u Department of Internal Medicine, Kralovske Vinohrady University Hospital and Third Faculty of Medicine, Charles University, 10000 Prague, Czech Republic $1 https://orcid.org/0000000279955947
700    1_
$a Cahova, Monika $u Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic $1 https://orcid.org/0000000326405084 $7 xx0070633
773    0_
$w MED00189563 $t Nutrients $x 2072-6643 $g Roč. 15, č. 2 (2023)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36678325 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20230418 $b ABA008
991    __
$a 20230425171610 $b ABA008
999    __
$a ok $b bmc $g 1924958 $s 1190786
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2023 $b 15 $c 2 $e 20230115 $i 2072-6643 $m Nutrients $n Nutrients $x MED00189563
LZP    __
$a Pubmed-20230418

Najít záznam

Citační ukazatele

Možnosti archivace