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Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy
N. Daskova, M. Heczkova, I. Modos, J. Hradecky, T. Hudcovic, M. Kuzma, H. Pelantova, I. Buskova, E. Sticova, D. Funda, J. Golias, B. Drabonova, J. Jarkovska, M. Kralova, I. Cibulkova, J. Gojda, M. Cahova
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2009
Free Medical Journals
od 2009
PubMed Central
od 2009
Europe PubMed Central
od 2009
ProQuest Central
od 2009-01-01
Open Access Digital Library
od 2009-01-01
Open Access Digital Library
od 2009-01-01
Health & Medicine (ProQuest)
od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2009
PubMed
36678325
DOI
10.3390/nu15020454
Knihovny.cz E-zdroje
- MeSH
- fekální transplantace MeSH
- glukosa farmakologie MeSH
- inulin farmakologie MeSH
- lidé MeSH
- myši MeSH
- potravní vláknina farmakologie MeSH
- střevní mikroflóra * MeSH
- vegani MeSH
- západní dieta MeSH
- ztučnělá játra * prevence a kontrola farmakoterapie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Fecal microbiota transfer may serve as a therapeutic tool for treating obesity and related disorders but currently, there is no consensus regarding the optimal donor characteristics. We studied how microbiota from vegan donors, who exhibit a low incidence of non-communicable diseases, impact on metabolic effects of an obesogenic diet and the potential role of dietary inulin in mediating these effects. Ex-germ-free animals were colonized with human vegan microbiota and fed a standard or Western-type diet (WD) with or without inulin supplementation. Despite the colonization with vegan microbiota, WD induced excessive weight gain, impaired glucose metabolism, insulin resistance, and liver steatosis. However, supplementation with inulin reversed steatosis and improved glucose homeostasis. In contrast, inulin did not affect WD-induced metabolic changes in non-humanized conventional mice. In vegan microbiota-colonized mice, inulin supplementation resulted in a significant change in gut microbiota composition and its metabolic performance, inducing the shift from proteolytic towards saccharolytic fermentation (decrease of sulfur-containing compounds, increase of SCFA). We found that (i) vegan microbiota alone does not protect against adverse effects of WD; and (ii) supplementation with inulin reversed steatosis and normalized glucose metabolism. This phenomenon is associated with the shift in microbiota composition and accentuation of saccharolytic fermentation at the expense of proteolytic fermentation.
1st Faculty of Medicine Charles University Katerinska 1660 32 12108 Prague Czech Republic
Department of Applied Mathematics and Computer Science Masaryk University 60177 Brno Czech Republic
Faculty of Forestry and Wood Sciences Czech University of Life Sciences 16500 Prague Czech Republic
Institute for Clinical and Experimental Medicine 14021 Prague Czech Republic
Institute of Microbiology of the CAS 14220 Prague Czech Republic
Citace poskytuje Crossref.org
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