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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
C. Fernandez-Rozadilla, M. Timofeeva, Z. Chen, P. Law, M. Thomas, S. Schmit, V. Díez-Obrero, L. Hsu, J. Fernandez-Tajes, C. Palles, K. Sherwood, S. Briggs, V. Svinti, K. Donnelly, S. Farrington, J. Blackmur, P. Vaughan-Shaw, XO. Shu, J. Long, Q....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, metaanalýza, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
12076
Cancer Research UK - United Kingdom
C6199/A16459
Cancer Research UK - United Kingdom
U01 CA137088
NCI NIH HHS - United States
G0700704
Medical Research Council - United Kingdom
U01 CA164930
NCI NIH HHS - United States
C1298/A25514
Cancer Research UK - United Kingdom
C348/A12076
Cancer Research UK - United Kingdom
U01 CA074783
NCI NIH HHS - United States
P01 CA196569
NCI NIH HHS - United States
R01 CA059045
NCI NIH HHS - United States
R01 CA197350
NCI NIH HHS - United States
R01 CA188214
NCI NIH HHS - United States
P30 CA015704
NCI NIH HHS - United States
29186
Cancer Research UK - United Kingdom
R01 CA206279
NCI NIH HHS - United States
S10 OD028685
NIH HHS - United States
R37 CA070867
NCI NIH HHS - United States
MC_U127527198
Medical Research Council - United Kingdom
MR/K018647/1
Medical Research Council - United Kingdom
R01 CA244588
NCI NIH HHS - United States
HHSN268201200008C
NHLBI NIH HHS - United States
C6199/A27327
Cancer Research UK - United Kingdom
U01 CA167551
NCI NIH HHS - United States
P30 CA014089
NCI NIH HHS - United States
R01 CA148667
NCI NIH HHS - United States
R01 CA081488
NCI NIH HHS - United States
R01 CA124558
NCI NIH HHS - United States
R01 CA201407
NCI NIH HHS - United States
P30 CA068485
NCI NIH HHS - United States
T32 ES013678
NIEHS NIH HHS - United States
MC_UU_00007/1
Medical Research Council - United Kingdom
MR/P001106/1
Medical Research Council - United Kingdom
UM1 CA182910
NCI NIH HHS - United States
R01 CA158473
NCI NIH HHS - United States
HHSN268201200008I
NHLBI NIH HHS - United States
MC_PC_U127527198
Medical Research Council - United Kingdom
U19 CA148107
NCI NIH HHS - United States
22804
Cancer Research UK - United Kingdom
MR/K026992/1
Medical Research Council - United Kingdom
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- celogenomová asociační studie MeSH
- Evropané * genetika MeSH
- genetická predispozice k nemoci MeSH
- jednonukleotidový polymorfismus genetika MeSH
- kolorektální nádory * genetika MeSH
- lidé MeSH
- multiomika MeSH
- východní Asiaté * genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.
Bioinformatics and Data Science Research Center Bina Nusantara University Jakarta Indonesia
Biomedicine Institute University of León León Spain
Broad Institute of Harvard and MIT Cambridge MA USA
Broad Institute of MIT and Harvard Cambridge MA USA
Cancer Center University of Hawaii Honolulu HI USA
Cancer Epidemiology Division Cancer Council Victoria Melbourne Victoria Australia
Cancer Epidemiology Program H Lee Moffitt Cancer Center and Research Institute Tampa FL USA
Cancer Immunology Program Dana Farber Harvard Cancer Center Boston MA USA
Cancer Research Institute Seoul National University Seoul South Korea
Candiolo Cancer Institute FPO IRCCS Candiolo Italy
Case Comprehensive Cancer Center Case Western Reserve University Cleveland OH USA
Center for Gastrointestinal Biology and Disease University of North Carolina Chapel Hill NC USA
Central Finland Health Care District Jyväskylä Finland
Centre for Global Health Usher Institute University of Edinburgh Edinburgh UK
City of Hope National Medical Center Translational Genomics Research Institute Phoenix AZ USA
Clalit Health Services Personalized Genomic Service Lady Davis Carmel Medical Center Haifa Israel
Clalit National Cancer Control Center Haifa Israel
Colorectal Cancer Group ONCOBELL Program Bellvitge Biomedical Research Institute Barcelona Spain
Comprehensive Cancer Center University of Puerto Rico San Juan Puerto Rico
Consortium for Biomedical Research in Epidemiology and Public Health Madrid Madrid Spain
Consortium for Biomedical Research in Epidemiology and Public Health Madrid Spain
Department of Biomedical Informatics Vanderbilt University School of Medicine Nashville TN USA
Department of Biostatistics School of Public Health University of Washington Seattle WA USA
Department of Biostatistics University of Washington Seattle WA USA
Department of Clinical Genetics Karolinska University Hospital Stockholm Sweden
Department of Clinical Pathology University of Melbourne Melbourne Victoria Australia
Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain
Department of Community Medicine and Epidemiology Lady Davis Carmel Medical Center Haifa Israel
Department of Computer Science Stanford University Stanford CA USA
Department of Epidemiology and Population Health Albert Einstein College of Medicine New York NY USA
Department of Epidemiology Harvard T H Chan School of Public Health Harvard University Boston MA USA
Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA
Department of Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan
Department of Epidemiology University of Washington School of Public Health Seattle WA USA
Department of Epidemiology University of Washington Seattle WA USA
Department of Family Medicine and Public Health University of California San Diego La Jolla CA USA
Department of Gastroenterology Kaiser Permanente Medical Center San Francisco CA USA
Department of General Surgery University Hospital Rostock Rostock Germany
Department of Genetics and Genome Sciences Case Western Reserve University Cleveland OH USA
Department of Genetics Stanford University Stanford CA USA
Department of Genome Sciences University of Washington Seattle WA USA
Department of Health and Welfare Finnish Institute for Health and Welfare Helsinki Finland
Department of Hygiene and Epidemiology University of Ioannina School of Medicine Ioannina Greece
Department of Internal Medicine University of Utah Salt Lake City UT USA
Department of Laboratory Medicine and Pathology Mayo Clinic Arizona Scottsdale AZ USA
Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland
Department of Medicine 1 University Hospital Dresden Technische Universität Dresden Dresden Germany
Department of Medicine and Epidemiology University of Pittsburgh Medical Center Pittsburgh PA USA
Department of Medicine Boston University School of Medicine Boston MA USA
Department of Medicine Keck School of Medicine University of Southern California Los Angeles CA USA
Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA
Department of Medicine Weill Cornell Medical College New York NY USA
Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden
Department of Nutritional Sciences School of Public Health University of Michigan Ann Arbor MI USA
Department of Oncology University of Oxford Oxford UK
Department of Oncology University of Toronto Toronto Ontario Canada
Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA USA
Department of Pathology Central Finland Health Care District Jyväskylä Finland
Department of Pathology Johns Hopkins School of Medicine Baltimore MD USA
Department of Pathology University of Michigan Ann Arbor MI USA
Department of Preventive Medicine Chonnam National University Medical School Gwangju South Korea
Department of Preventive Medicine Seoul National University College of Medicine Seoul South Korea
Department of Public Health and Primary Care University of Cambridge Cambridge UK
Department of Public Health and Welfare Finnish Institute for Health and Welfare Helsinki Finland
Department of Public Health Richard Doll Building University of Oxford Oxford UK
Department of Radiation Sciences Oncology Unit Umeå University Umeå Sweden
Department of Surgery Abdominal Centre Helsinki University Hospital Helsinki Finland
Department of Surgery University of Tennessee Health Science Center Memphis TN USA
Division of Biomedical Sciences Memorial University of Newfoundland St John Ontario Canada
Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan
Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany
Division of Gastroenterology Massachusetts General Hospital and Harvard Medical School Boston MA USA
Division of Genetics and Epidemiology Institute of Cancer Research London UK
Division of Human Nutrition and Health Wageningen University and Research Wageningen The Netherlands
Division of Human Nutrition Wageningen University and Research Wageningen The Netherlands
Division of Molecular and Clinical Epidemiology Aichi Cancer Center Research Institute Nagoya Japan
Division of Research Kaiser Permanente Northern California Oakland CA USA
Faculty of Medicine and Biomedical Center in Pilsen Charles University Pilsen Czech Republic
Faculty of Social Sciences Tampere University Tampere Finland
Folkhälsan Research Centre University of Helsinki Helsinki Finland
Fred Hutchinson Cancer Research Center Seattle WA USA
Genome Scale Biology Research Program University of Helsinki Helsinki Finland
Genomic Medicine and Family Cancer Clinic Royal Melbourne Hospital Parkville Victoria Australia
Genomic Medicine Group Instituto de Investigacion Sanitaria de Santiago Santiago de Compostela Spain
Genomic Medicine Institute Cleveland Clinic Cleveland OH USA
German Cancer Consortium German Cancer Research Center Heidelberg Germany
Institute of Cancer Research Department of Medicine 1 Medical University Vienna Vienna Austria
Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
Institute of Medical Genetics Cardiff University Cardiff UK
Institute of Nutritional Science University of Potsdam Potsdam Germany
Instituto de Investigación Sanitaria de Santiago de Compostela Santiago de Compostela Spain
Italian Institute for Genomic Medicine Candiolo Cancer Institute FPO IRCCS Candiolo Italy
Jeonnam Regional Cancer Center Chonnam National University Hwasun Hospital Hwasun South Korea
Kaiser Permanente Washington Health Research Institute Seattle WA USA
Leeds Institute of Medical Research at St James's University of Leeds Leeds UK
Lothian Birth Cohorts group Department of Psychology University of Edinburgh Edinburgh UK
Menzies Institute for Medical Research University of Tasmania Hobart Tasmania Australia
MRC Clinical Trials Unit Medical Research Council Cardiff UK
MRC Human Genetics Unit Institute of Genomics and Cancer University of Edinburgh Edinburgh UK
MRC Institute for Radiation Oncology University of Oxford Oxford UK
Nuffield Department of Population Health University of Oxford Oxford UK
Oncology Data Analytics Program Catalan Institute of Oncology Barcelona Spain
Ontario Institute for Cancer Research Toronto Ontario Canada
Population and Cancer Prevention Program Case Comprehensive Cancer Center Cleveland OH USA
Preventative Medicine University of Southern California Los Angeles CA USA
Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA
Radcliffe Department of Medicine University of Oxford Oxford UK
Research Centre for Hauora and Health Massey University Wellington New Zealand
Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel
School of Public Health Sun Yat sen University Guangzhou China
School of Public Health University of Washington Seattle WA USA
Service de Génétique Médicale Centre Hospitalier Universitaire Nantes Nantes France
Slone Epidemiology Center at Boston University Boston MA USA
State Key Laboratory of Oncology in South China Cancer Center Sun Yat sen University Guangzhou China
SWOG Statistical Center Fred Hutchinson Cancer Research Center Seattle WA USA
Taipei Medical University Taipei Taiwan
University Medical Centre Hamburg Eppendorf University Cancer Centre Hamburg Hamburg Germany
Van Andel Research Institute Grand Rapids MI USA
Wallenberg Centre for Molecular Medicine Umeå University Umeå Sweden
Citace poskytuje Crossref.org
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- $a Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries / $c C. Fernandez-Rozadilla, M. Timofeeva, Z. Chen, P. Law, M. Thomas, S. Schmit, V. Díez-Obrero, L. Hsu, J. Fernandez-Tajes, C. Palles, K. Sherwood, S. Briggs, V. Svinti, K. Donnelly, S. Farrington, J. Blackmur, P. Vaughan-Shaw, XO. Shu, J. Long, Q. Cai, X. Guo, Y. Lu, P. Broderick, J. Studd, J. Huyghe, T. Harrison, D. Conti, C. Dampier, M. Devall, F. Schumacher, M. Melas, G. Rennert, M. Obón-Santacana, V. Martín-Sánchez, F. Moratalla-Navarro, JH. Oh, J. Kim, SH. Jee, KJ. Jung, SS. Kweon, MH. Shin, A. Shin, YO. Ahn, DH. Kim, I. Oze, W. Wen, K. Matsuo, K. Matsuda, C. Tanikawa, Z. Ren, YT. Gao, WH. Jia, J. Hopper, M. Jenkins, AK. Win, R. Pai, J. Figueiredo, R. Haile, S. Gallinger, M. Woods, P. Newcomb, D. Duggan, J. Cheadle, R. Kaplan, T. Maughan, R. Kerr, D. Kerr, I. Kirac, J. Böhm, LP. Mecklin, P. Jousilahti, P. Knekt, L. Aaltonen, H. Rissanen, E. Pukkala, J. Eriksson, T. Cajuso, U. Hänninen, J. Kondelin, K. Palin, T. Tanskanen, L. Renkonen-Sinisalo, B. Zanke, S. Männistö, D. Albanes, S. Weinstein, E. Ruiz-Narvaez, J. Palmer, D. Buchanan, E. Platz, K. Visvanathan, C. Ulrich, E. Siegel, S. Brezina, A. Gsur, P. Campbell, J. Chang-Claude, M. Hoffmeister, H. Brenner, M. Slattery, J. Potter, K. Tsilidis, M. Schulze, M. Gunter, N. Murphy, A. Castells, S. Castellví-Bel, L. Moreira, V. Arndt, A. Shcherbina, M. Stern, B. Pardamean, T. Bishop, G. Giles, M. Southey, G. Idos, K. McDonnell, Z. Abu-Ful, J. Greenson, K. Shulman, F. Lejbkowicz, K. Offit, YR. Su, R. Steinfelder, T. Keku, B. van Guelpen, T. Hudson, H. Hampel, R. Pearlman, S. Berndt, R. Hayes, ME. Martinez, S. Thomas, D. Corley, P. Pharoah, S. Larsson, Y. Yen, HJ. Lenz, E. White, L. Li, K. Doheny, E. Pugh, T. Shelford, A. Chan, M. Cruz-Correa, A. Lindblom, D. Hunter, A. Joshi, C. Schafmayer, P. Scacheri, A. Kundaje, D. Nickerson, R. Schoen, J. Hampe, Z. Stadler, P. Vodicka, L. Vodickova, V. Vymetalkova, N. Papadopoulos, C. Edlund, W. Gauderman, D. Thomas, D. Shibata, A. Toland, S. Markowitz, A. Kim, S. Chanock, F. van Duijnhoven, E. Feskens, L. Sakoda, M. Gago-Dominguez, A. Wolk, A. Naccarati, B. Pardini, L. FitzGerald, SC. Lee, S. Ogino, S. Bien, C. Kooperberg, C. Li, Y. Lin, R. Prentice, C. Qu, S. Bézieau, C. Tangen, E. Mardis, T. Yamaji, N. Sawada, M. Iwasaki, C. Haiman, L. Le Marchand, A. Wu, C. Qu, C. McNeil, G. Coetzee, C. Hayward, I. Deary, S. Harris, E. Theodoratou, S. Reid, M. Walker, LY. Ooi, V. Moreno, G. Casey, S. Gruber, I. Tomlinson, W. Zheng, M. Dunlop, R. Houlston, U. Peters
- 520 9_
- $a Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.
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- $a Chen, Zhishan $u Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA
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- $a Law, Philip $u Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK $1 https://orcid.org/0000000196634611
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Abu-Ful, Zomoroda $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Cruz-Correa, Marcia $u Comprehensive Cancer Center, University of Puerto Rico, San Juan, Puerto Rico
- 700 1_
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- 700 1_
- $a Hunter, David $u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA $u Nuffield Department of Population Health, University of Oxford, Oxford, UK
- 700 1_
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- 700 1_
- $a Schafmayer, Clemens $u Department of General Surgery, University Hospital Rostock, Rostock, Germany
- 700 1_
- $a Scacheri, Peter $u Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA
- 700 1_
- $a Kundaje, Anshul $u Department of Genetics, Stanford University, Stanford, CA, USA $u Department of Computer Science, Stanford University, Stanford, CA, USA $1 https://orcid.org/0000000330842287
- 700 1_
- $a Nickerson, Deborah $u Department of Genome Sciences, University of Washington, Seattle, WA, USA
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Vodicka, Pavel $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
- 700 1_
- $a Vodickova, Ludmila $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
- 700 1_
- $a Vymetalkova, Veronika $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic
- 700 1_
- $a Papadopoulos, Nickolas $u Department of Oncology Ludwig Center at the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA $u Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA $u Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA $1 https://orcid.org/0000000171357451
- 700 1_
- $a Edlund, Chistopher $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
- $a Gauderman, William $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
- $a Thomas, Duncan $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA $1 https://orcid.org/0000000260408804
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Kim, Andre $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
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- 700 1_
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- 700 1_
- $a Feskens, Edith $u Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands $1 https://orcid.org/0000000158192488
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- 700 1_
- $a Gago-Dominguez, Manuela $u Genomic Medicine Group, Galician Public Foundation of Genomic Medicine, Servicio Galego de Saude, Santiago de Compostela, Spain $u Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain
- 700 1_
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- 700 1_
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- $a FitzGerald, Liesel $u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia $u Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia $1 https://orcid.org/0000000268822698
- 700 1_
- $a Lee, Soo Chin $u National University Cancer Institute, Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
- 700 1_
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- 700 1_
- $a Bien, Stephanie $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
- 700 1_
- $a Kooperberg, Charles $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA $1 https://orcid.org/0000000279868560
- 700 1_
- $a Li, Christopher $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
- 700 1_
- $a Lin, Yi $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
- 700 1_
- $a Prentice, Ross $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA $u Department of Biostatistics, University of Washington, Seattle, WA, USA
- 700 1_
- $a Qu, Conghui $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Yamaji, Taiki $u Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
- 700 1_
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- 700 1_
- $a Iwasaki, Motoki $u Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan $u Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Qu, Chenxu $u USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
- $a McNeil, Caroline $u USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Walker, Marion $u Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
- 700 1_
- $a Ooi, Li Yin $u Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK $u Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore $1 https://orcid.org/0000000255882130
- 700 1_
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