-
Something wrong with this record ?
Dynamic Evolution of Avian RNA Virus Sensors: Repeated Loss of RIG-I and RIPLET
V. Krchlíková, T. Hron, M. Těšický, T. Li, L. Ungrová, J. Hejnar, M. Vinkler, D. Elleder
Language English Country Switzerland
Document type Journal Article
NLK
Directory of Open Access Journals
from 2009
Free Medical Journals
from 2009
PubMed Central
from 2009
Europe PubMed Central
from 2009
ProQuest Central
from 2009-01-01
Open Access Digital Library
from 2009-01-01
Open Access Digital Library
from 2009-01-01
Health & Medicine (ProQuest)
from 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2009
PubMed
36680044
DOI
10.3390/v15010003
Knihovny.cz E-resources
- MeSH
- Antiviral Agents MeSH
- DEAD Box Protein 58 genetics metabolism MeSH
- Immunity, Innate MeSH
- Birds virology MeSH
- RNA Helicases MeSH
- RNA Viruses * physiology MeSH
- RNA * MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are key RNA virus sensors belonging to the RIG-I-like receptor (RLR) family. The activation of the RLR inflammasome leads to the establishment of antiviral state, mainly through interferon-mediated signaling. The evolutionary dynamics of RLRs has been studied mainly in mammals, where rare cases of RLR gene losses were described. By in silico screening of avian genomes, we previously described two independent disruptions of MDA5 in two bird orders. Here, we extend this analysis to approximately 150 avian genomes and report 16 independent evolutionary events of RIG-I inactivation. Interestingly, in almost all cases, these inactivations are coupled with genetic disruptions of RIPLET/RNF135, an ubiquitin ligase RIG-I regulator. Complete absence of any detectable RIG-I sequences is unique to several galliform species, including the domestic chicken (Gallus gallus). We further aimed to determine compensatory evolution of MDA5 in RIG-I-deficient species. While we were unable to show any specific global pattern of adaptive evolution in RIG-I-deficient species, in galliforms, the analyses of positive selection and surface charge distribution support the hypothesis of some compensatory evolution in MDA5 after RIG-I loss. This work highlights the dynamic nature of evolution in bird RNA virus sensors.
Department of Zoology Faculty of Science Charles University 12843 Prague Czech Republic
Institute of Molecular Genetics of the Czech Academy of Sciences 14220 Prague Czech Republic
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc23004902
- 003
- CZ-PrNML
- 005
- 20230425171801.0
- 007
- ta
- 008
- 230418s2022 sz f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.3390/v15010003 $2 doi
- 035 __
- $a (PubMed)36680044
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a sz
- 100 1_
- $a Krchlíková, Veronika $u Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic $1 https://orcid.org/0000000191925866
- 245 10
- $a Dynamic Evolution of Avian RNA Virus Sensors: Repeated Loss of RIG-I and RIPLET / $c V. Krchlíková, T. Hron, M. Těšický, T. Li, L. Ungrová, J. Hejnar, M. Vinkler, D. Elleder
- 520 9_
- $a Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) are key RNA virus sensors belonging to the RIG-I-like receptor (RLR) family. The activation of the RLR inflammasome leads to the establishment of antiviral state, mainly through interferon-mediated signaling. The evolutionary dynamics of RLRs has been studied mainly in mammals, where rare cases of RLR gene losses were described. By in silico screening of avian genomes, we previously described two independent disruptions of MDA5 in two bird orders. Here, we extend this analysis to approximately 150 avian genomes and report 16 independent evolutionary events of RIG-I inactivation. Interestingly, in almost all cases, these inactivations are coupled with genetic disruptions of RIPLET/RNF135, an ubiquitin ligase RIG-I regulator. Complete absence of any detectable RIG-I sequences is unique to several galliform species, including the domestic chicken (Gallus gallus). We further aimed to determine compensatory evolution of MDA5 in RIG-I-deficient species. While we were unable to show any specific global pattern of adaptive evolution in RIG-I-deficient species, in galliforms, the analyses of positive selection and surface charge distribution support the hypothesis of some compensatory evolution in MDA5 after RIG-I loss. This work highlights the dynamic nature of evolution in bird RNA virus sensors.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a antivirové látky $7 D000998
- 650 _2
- $a ptáci $x virologie $7 D001717
- 650 _2
- $a DEAD box protein 58 $x genetika $x metabolismus $7 D000071457
- 650 _2
- $a přirozená imunita $7 D007113
- 650 12
- $a RNA $7 D012313
- 650 _2
- $a RNA-helikasy $7 D020365
- 650 12
- $a RNA-viry $x fyziologie $7 D012328
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Hron, Tomáš $u Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic $1 https://orcid.org/0000000205892568
- 700 1_
- $a Těšický, Martin $u Department of Zoology, Faculty of Science, Charles University, 12843 Prague, Czech Republic
- 700 1_
- $a Li, Tao $u Department of Zoology, Faculty of Science, Charles University, 12843 Prague, Czech Republic $1 https://orcid.org/0000000231336194
- 700 1_
- $a Ungrová, Lenka $u Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic
- 700 1_
- $a Hejnar, Jiří $u Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic
- 700 1_
- $a Vinkler, Michal $u Department of Zoology, Faculty of Science, Charles University, 12843 Prague, Czech Republic $1 https://orcid.org/0000000335729494 $7 mub2013779697
- 700 1_
- $a Elleder, Daniel $u Institute of Molecular Genetics of the Czech Academy of Sciences, 14220 Prague, Czech Republic $1 https://orcid.org/0000000190415274
- 773 0_
- $w MED00177099 $t Viruses $x 1999-4915 $g Roč. 15, č. 1 (2022)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/36680044 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230418 $b ABA008
- 991 __
- $a 20230425171757 $b ABA008
- 999 __
- $a ok $b bmc $g 1925157 $s 1191111
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2022 $b 15 $c 1 $e 20221220 $i 1999-4915 $m Viruses $n Viruses $x MED00177099
- LZP __
- $a Pubmed-20230418