Aim: The aim of the presented study was to compare differences in craniofacial morphology with a focus on the degree and intensity of mandible growth in patients with Pierre Robin sequence, patients with isolated cleft palate, and healthy population. Material and method: Growth changes were measured in 40 patients with isolated cleft palate and in 20 patients with Pierre Robin sequence in 2 cephalograms taken at the interval of at least two years. The first cephalogram was taken at the age of 9-12 (T0), and it was clear from the OPG that it was performed prior to a growth spurt. The second cephalogram was taken after at least 2 years under the same technical conditions, i.e. at the age of 12.5–16 years (T1). The values were compared with reference values of healthy population of the same age taken from the study by Riola (1974). Results: In patients with Pierre Robin sequence the mandible is hypoplastic compared to patients with isolated cleft palate and healthy individuals. At T0 the mandible in patients with Pierre Robin sequence reached 92.8 % of the average length of the mandible in patients with isolated cleft palate (p = 0.001), at T1 it was 92 % (p = 0.0002). A comparison with healthy population revealed greater discrepancy. At T0 the mandible of patients with Pierre Robin sequence reached 91.3 % of the length of the mandible in healthy individuals (p < 0.0001), at T1 it was 91 % (p < 0.0001). The most significant discrepancy contributing to the mandible hypoplasia in patients with Pierre Robin sequence was found in the length of the mandible body. Conclusion: In patients with Pierre Robin sequence the mandible is permanently insufficient. The growth appears constant, it does not accelerate or decelerate during a growth spurt.

Oddělení ortodoncie a rozštěpových vad Stomatologické kliniky 3 LF UK FNKV Praha

Ústav lékařské biofyziky LF UP Olomouc

Growth of the mandible in patients with Pierre Robin sequence

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