Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens.

Consejo Nacional de Investigaciones Científicas y Técnicas Ciudad Autónoma de Buenos Aires C1033AAJ Argentina

Faculty of Science University of South Bohemia CZ 370 05 České Budějovice Czech Republic

Institute of Parasitology Biology Centre Academy of Sciences of the Czech Republic Branišovská 1160 31 CZ 37005 České Budějovice Czech Republic

Instituto de Patobiología Veterinaria Centro de Investigaciones en Ciencias Veterinarias y Agronómicas INTA Castelar Los Reseros y Nicolas Repetto s n Hurlingham 1686 Argentina

Washington State University Animal Disease Research Unit USDA Pullman WA USA

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$a Florin-Christensen, Monica $u Instituto de Patobiología Veterinaria, Centro de Investigaciones en Ciencias Veterinarias y Agronómicas (CICVyA), INTA-Castelar, Los Reseros y Nicolas Repetto s/n, Hurlingham 1686, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires C1033AAJ, Argentina. Electronic address: jacobsen.monica@inta.gob.ar

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$a Degrade to survive: the intricate world of piroplasmid proteases / $c M. Florin-Christensen, D. Sojka, S. Ganzinelli, P. Šnebergerová, CE. Suarez, L. Schnittger

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$a Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens.

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$a Šnebergerová, Pavla $u Institute of Parasitology, Biology Centre, Academy of Sciences of the Czech Republic, Branišovská 1160/31, CZ-37005 České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, CZ-370 05 České Budějovice, Czech Republic

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$a Suarez, Carlos E $u Washington State University/Animal Disease Research Unit USDA, Pullman, WA, USA

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