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Radon and lung cancer in the pooled uranium miners analysis (PUMA): highly exposed early miners and all miners
K. Kelly-Reif, SJ. Bertke, E. Rage, PA. Demers, N. Fenske, V. Deffner, M. Kreuzer, J. Samet, MK. Schubauer-Berigan, L. Tomasek, LB. Zablotska, C. Wiggins, D. Laurier, DB. Richardson
Language English Country England, Great Britain
Document type Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't
Grant support
R03 OH010946
NIOSH CDC HHS - United States
R21 OH011452
NIOSH CDC HHS - United States
NLK
ProQuest Central
from 1994-01-01 to 6 months ago
Nursing & Allied Health Database (ProQuest)
from 1994-01-01 to 6 months ago
Health & Medicine (ProQuest)
from 1994-01-01 to 6 months ago
Public Health Database (ProQuest)
from 1994-01-01 to 6 months ago
- MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Lung Neoplasms * etiology MeSH
- Neoplasms, Radiation-Induced * epidemiology etiology MeSH
- Occupational Diseases * epidemiology etiology MeSH
- Occupational Exposure * adverse effects MeSH
- Apoptosis Regulatory Proteins MeSH
- Radon * adverse effects MeSH
- Uranium * adverse effects MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
OBJECTIVES: Radon is a ubiquitous occupational and environmental lung carcinogen. We aim to quantify the association between radon progeny and lung cancer mortality in the largest and most up-to-date pooled study of uranium miners. METHODS: The pooled uranium miners analysis combines 7 cohorts of male uranium miners with 7754 lung cancer deaths and 4.3 million person-years of follow-up. Vital status and lung cancer deaths were ascertained between 1946 and 2014. The association between cumulative radon exposure in working level months (WLM) and lung cancer was modelled as the excess relative rate (ERR) per 100 WLM using Poisson regression; variation in the association by temporal and exposure factors was examined. We also examined analyses restricted to miners first hired before 1960 and with <100 WLM cumulative exposure. RESULTS: In a model that allows for variation by attained age, time since exposure and annual exposure rate, the ERR/100 WLM was 4.68 (95% CI 2.88 to 6.96) among miners who were less than 55 years of age and were exposed in the prior 5 to <15 years at annual exposure rates of <0.5 WL. This association decreased with older attained age, longer time since exposure and higher annual exposure rate. In analyses restricted to men first hired before 1960, we observed similar patterns of association but a slightly lower estimate of the ERR/100 WLM. CONCLUSIONS: This new large, pooled study confirms and supports a linear exposure-response relationship between cumulative radon exposure and lung cancer mortality which is jointly modified by temporal and exposure factors.
Colorado School of Public Health Aurora Colorado USA
Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada
Epidemiology and Biostatistics University of California San Francisco California USA
Evidence Synthesis and Classification Branch International Agency for Research on Cancer Lyon France
Federal Office for Radiation Protection Germany
Institute for Radiological Protection and Nuclear Safety Fontenay aux Roses France
National Radiation Protection Institute Prague Czech Republic
New Mexico Tumor Registry Albuquerque Mexico USA
Occupational Cancer Research Centre Ontario Health Toronto Ontario Canada
References provided by Crossref.org
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