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Associations of height, body mass index, and weight gain with breast cancer risk in carriers of a pathogenic variant in BRCA1 or BRCA2: the BRCA1 and BRCA2 Cohort Consortium
K. Kast, EM. John, JL. Hopper, N. Andrieu, C. Noguès, E. Mouret-Fourme, C. Lasset, JP. Fricker, P. Berthet, V. Mari, L. Salle, MK. Schmidt, MGEM. Ausems, EBG. Garcia, I. van de Beek, MR. Wevers, DG. Evans, M. Tischkowitz, F. Lalloo, J. Cook, L....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, N.I.H., Extramural
Grantová podpora
U01 CA164920
NCI NIH HHS - United States
PRCPJT-Nov21\100004
Cancer Research UK - United Kingdom
C1287/A23382
Cancer Research UK - United Kingdom
C1287/A26886
Cancer Research UK - United Kingdom
BRC-1215-20014
Department of Health - United Kingdom
NIHR203312
Department of Health - United Kingdom
IS-BRC-1215-20007
Department of Health - United Kingdom
NLK
BioMedCentral
od 1999-12-01
BioMedCentral Open Access
od 1999
Directory of Open Access Journals
od 2000
Free Medical Journals
od 1999 do Před 2 roky
PubMed Central
od 1999
Europe PubMed Central
od 1999
ProQuest Central
od 2015-01-01
Open Access Digital Library
od 1999-07-01
Open Access Digital Library
od 1999-01-01
Open Access Digital Library
od 2000-01-01
Health & Medicine (ProQuest)
od 2015-01-01
ROAD: Directory of Open Access Scholarly Resources
od 1999
Springer Nature OA/Free Journals
od 1999-12-01
- MeSH
- dospělí MeSH
- genetická predispozice k nemoci MeSH
- geny BRCA2 * MeSH
- heterozygot MeSH
- hmotnostní přírůstek genetika MeSH
- index tělesné hmotnosti MeSH
- lidé MeSH
- nádory prsu * epidemiologie genetika patologie MeSH
- protein BRCA1 genetika MeSH
- protein BRCA2 genetika MeSH
- retrospektivní studie MeSH
- riziko MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
INTRODUCTION: Height, body mass index (BMI), and weight gain are associated with breast cancer risk in the general population. It is unclear whether these associations also exist for carriers of pathogenic variants in the BRCA1 or BRCA2 genes. PATIENTS AND METHODS: An international pooled cohort of 8091 BRCA1/2 variant carriers was used for retrospective and prospective analyses separately for premenopausal and postmenopausal women. Cox regression was used to estimate breast cancer risk associations with height, BMI, and weight change. RESULTS: In the retrospective analysis, taller height was associated with risk of premenopausal breast cancer for BRCA2 variant carriers (HR 1.20 per 10 cm increase, 95% CI 1.04-1.38). Higher young-adult BMI was associated with lower premenopausal breast cancer risk for both BRCA1 (HR 0.75 per 5 kg/m2, 95% CI 0.66-0.84) and BRCA2 (HR 0.76, 95% CI 0.65-0.89) variant carriers in the retrospective analysis, with consistent, though not statistically significant, findings from the prospective analysis. In the prospective analysis, higher BMI and adult weight gain were associated with higher postmenopausal breast cancer risk for BRCA1 carriers (HR 1.20 per 5 kg/m2, 95% CI 1.02-1.42; and HR 1.10 per 5 kg weight gain, 95% CI 1.01-1.19, respectively). CONCLUSION: Anthropometric measures are associated with breast cancer risk for BRCA1 and BRCA2 variant carriers, with relative risk estimates that are generally consistent with those for women from the general population.
Aix Marseille Université INSERM IRD SESSTIM Marseille France
Cancer Epidemiology Division Cancer Council Victoria Melbourne VIC Australia
Centre Antoine Lacassagne Nice France
Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge Cambridge UK
Centre François Baclesse Caen France
Centre Léon Bérard Lyon France
Clinical Genetics Karolinska Institutet Stockholm Sweden
Clinical Genetics Service Guy's and St Thomas' NHS Foundation Trust London UK
CRLCC Paul Strauss Strasbourg France
Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Clinical Genetics Fox Chase Cancer Center Philadelphia PA USA
Department of Clinical Genetics Guy's and St Thomas' NHS Foundation Trust London UK
Department of Clinical Genetics Maastricht University Medical Center Maastricht The Netherlands
Department of Clinical Genetics Radboud University Medical Center Nijmegen The Netherlands
Department of Clinical Genetics Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Department of Clinical Genetics St George's University Hospitals NHS Foundation Trust London UK
Department of Clinical Pathology The University of Melbourne Melbourne VIC Australia
Department of Dermatology University of Utah School of Medicine Salt Lake City UT USA
Department of Epidemiology Netherlands Cancer Institute Amsterdam The Netherlands
Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland
Department of Human Genetics Amsterdam UMC University of Amsterdam Amsterdam The Netherlands
Department of Medical Oncology Peter MacCallum Cancer Centre Victoria Australia
Department of Medicine and Huntsman Cancer Institute University of Utah Health Salt Lake City UT USA
Department of Molecular Genetics National Institute of Oncology Budapest Hungary
Department of Molecular Genetics University of Toronto Toronto ON Canada
Department of OB GYN and Comprehensive Cancer Center Medical University of Vienna Vienna Austria
Department of Oncology Clinical Sciences in Lund Lund University Hospital Lund Sweden
Institute for Medical Informatics Statistics and Epidemiology Leipzig University Leipzig Germany
Mines Paris Tech Fontainebleau France
Molecular Oncology Laboratory Hospital Clínico San Carlos IdISSC Madrid Spain
MRC Human Genetics Unit Institute of Genetics and Cancer University of Edinburgh Edinburgh UK
Oncogénétique Poitou Charentes Niort France
PSL Research University Paris France
Sheffield Clinical Genetics Service Sheffield Children's Hospital Sheffield UK
South East of Scotland Regional Genetics Service Western General Hospital Edinburgh UK
Stanford Cancer Institute Stanford University School of Medicine Stanford CA USA
The Sir Peter MacCallum Department of Oncology University of Melbourne Parkville Australia
Yorkshire Regional Genetics Service Leeds Teaching Hospitals NHS Trust Leeds UK
Citace poskytuje Crossref.org
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