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MUC5B rs35705950 minor allele associates with older age and better survival in idiopathic pulmonary fibrosis
JJ. van der Vis, A. Prasse, EA. Renzoni, CJW. Stock, C. Caliskan, TM. Maher, F. Bonella, R. Borie, B. Crestani, M. Petrek, WA. Wuyts, AE. Wind, PL. Molyneaux, JC. Grutters, CHM. van Moorsel
Jazyk angličtina Země Austrálie
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
36571111
DOI
10.1111/resp.14440
Knihovny.cz E-zdroje
- MeSH
- alely MeSH
- genetická predispozice k nemoci MeSH
- genotyp MeSH
- idiopatická plicní fibróza * genetika MeSH
- lidé MeSH
- mucin 5B genetika MeSH
- polymorfismus genetický MeSH
- retrospektivní studie MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND AND OBJECTIVE: The minor T-allele of the MUC5B promoter polymorphism rs35705950 is strongly associated with idiopathic pulmonary fibrosis (IPF). However, conflicting results have been reported on the relationship between the MUC5B minor allele and survival and it is unknown whether a specific subgroup of IPF patients might benefit from MUC5B minor allele carriage. We investigated the association between MUC5B rs35705950, survival and patient characteristics in a real-world population of European IPF patients. METHODS: In this retrospective study, 1751 patients with IPF from 8 European centres were included. MUC5B rs35705950 genotype, demographics, clinical characteristics at diagnosis and survival data were analysed. RESULTS: In a multi-variate Cox proportional hazard model the MUC5B minor allele was a significant independent predictor of survival when adjusted for age, sex, high resolution computed tomography pattern, smoking behaviour and pulmonary function tests in IPF. MUC5B minor allele carriers were significantly older at diagnosis (p = 0.001). The percentage of MUC5B minor allele carriers increased significantly with age from 44% in patients aged <56 year, to 63% in patients aged >75. In IPF patients aged <56, the MUC5B minor allele was not associated with survival. In IPF patients aged ≥56, survival was significantly better for MUC5B minor allele carriers (45 months [CI: 42-49]) compared to non-carriers (29 months [CI: 26-33]; p = 4 × 10-12 ). CONCLUSION: MUC5B minor allele carriage associates with a better median transplant-free survival of 16 months in the European IPF population aged over 56 years. MUC5B genotype status might aid disease prognostication in clinical management of IPF patients.
Division of Heart and Lungs University Medical Center Utrecht Utrecht the Netherlands
Division of Pulmonology Hannover Medical School and DZL BREATH Hannover Germany
European Reference Network ILD core Network center
Fraunhofer Institute ITEM Hannover Germany
Keck Medicine of University of Southern California Los Angeles California USA
Laboratoire d'excellence INFLAMEX Inserm U1152 Paris France
National Heart and Lung Institute Imperial College London London UK
Service de Pneumologie A Hôpital Bichat Paris France
University Hospital Olomouc Experimental Medicine Olomouc Czech Republic
Citace poskytuje Crossref.org
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